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News Article | May 15, 2017
Site: www.prweb.com

ARDA (American Resort Development Association) recently held its annual meeting in New Orleans, culminating with the presentation of industry awards. One of the most coveted for an independently owned and developed US resort, is the Circle of Excellence Award (ACE). “The ACE Domestic Project of Excellence Award recognizes a timeshare or mixed-use resort built within the United States which is considered the best of the best; taking into consideration, design, sustainability, impact on local community, sales and marketing and its day-to-day operations.” More than ten years in the making, Riverwalk Resort at Loon was presented this award at the final banquet on March 29, 2017. RiverWalk Resort at Loon and Developer Dennis Ducharme were nominated by one of their business partners; RCI. RCI is the leading provider of exchange vacations, offering the world’s largest vacation exchange network and providing unrivaled products and services to enhance the vacation ownership experience, through approximately 4,300 affiliated resorts in more than 100 countries. “RiverWalk at Loon Mountain is a gem in the RCI portfolio, and so deserving of the ACE Domestic Project of Excellence Award,” said Todd Menendez, Vice President of Business Development for RCI. “Every detail of the hospitality experience has been carefully thought-out, from the well-preserved history of the property to the exquisite on-site winery. The resort design has been developed with precision and expertise and it is reflected in an exceptional experience for guests.” “Receiving this award is a great compliment,” says Ducharme. “I was honored to accept this award on behalf of the team that has worked so hard to bring this vision to reality. ARDA has essentially recognized 10 years of work, from demolishing and remediating the Franconia Mill property, to the design and engineering and the actual construction of RiverWalk. I can’t tell you how many people were involved, but each one shared the extraordinary vision, so I share this with every one of them.” Judy Kenninger, RRP, of Resort Trades writes: “The stunning six-story resort with a bright red roof is located on 25 acres along the banks of the Pemigewasset River and provides easy access to skiing and outdoor activities as well as local restaurants and shops. Amenities include an on-site winery with tastings, full-service spa, 4,000 square foot fitness center, restaurant and lounge, game room, heated all-season pool, a one-of-a-kind skating rink with shows featuring past Olympians, and an Owners Club with personal storage lockers. When it opened last year, the luxurious units were already deemed worthy of RCI’s Gold Crown designation, and the top two floors are even included in RCI’s Registry Collection, the exchange company’s tier for elite travelers.” In addition to developing this extraordinary resort, Dennis is also the President of InnSeason Resorts, a collection of vacation ownership resorts throughout New England, which he has run for more than 25 years with, his partner, William E. “Billy” Curran, its CEO.


News Article | May 18, 2017
Site: marketersmedia.com

Royal Holiday Vacation Club has won the ARDY, the top award for its sales training program called Royal Connect. Royal Connect was selected as the ARDY winner from scores of entries in the sales training category. Royal Holiday offers hundreds of videos in its online training program in the English language, but it also offers the same videos in Spanish and Portuguese. The American Resort Development Association (ARDA) honored the popular vacation club for its strong commitment to delivering each sales and marketing training video in three different languages. The well-respected company stands out in the international resort development community. Since it offers its customers the option to visit over 180 destinations in 52 countries, a multi-lingual and multi-cultural approach to its sales and marketing program is crucial to its ongoing success. For the second year in a row, the company was named as a finalist in four ARDA Award Categories in its annual ARDA Award Competition Program. The finalists are selected from hundreds of entries. Royal Holiday Vacation Club, founded in 1983, offers its members more than 180 Luxury Beach Resorts, Hotels around the world, fully equipped condos, as well as more than 3,000 different cruises. The points based vacation club membership operator and resort developer has approximately 110,000 members from 52 countries. Rosario Rodriguez Rojo, CEO of Royal Holiday Vacation Club, said, "We are particularly honored to accept the award as it speaks to our commitment to provide professional training to all of our Royal Club Hosts who are there to ensure wonderful vacation experiences for our members from the moment they first meet with us." In addition to the ARDY for Royal Connect, the company was named as a top contender in the following categories: Winners of the coveted "ARDY" Award were announced at the industry association's annual gathering, ARDA World 2017 at the Hyatt Regency in New Orleans on March 29. Royal Holiday Vacation Club is Mexico City-based timeshare vacation club that is proud to have over 100,000 members in 52 countries, and is committed to offering the highest standard in quality service in the best hotels, affiliated resorts, condos, villas, international timeshares and cruise ships. Because of the many destinations and vacation offerings it provides, this nominee can meet and satisfy any vacationer's needs year after year. Royal Holiday caters to every demographic (age, lifestyle, nationality, single, married, families) and offers 180 destinations from the US to Canada, to Mexico, to the Caribbean, to South America, to Europe and other continents. Royal Holiday not only offers timeshare, condo and hotel options, but also cruises in popular destinations. By positioning itself as a points-based vacation club, this nominee guarantees its customers that they will be able to experience any kind of vacation they want year after year by adapting to their personal needs as they change over time. By embracing a wide range of demographics, lifestyles, locations and vacation styles, Royal Holiday provides lifelong vacations to all of its members.


News Article | May 19, 2017
Site: www.accesswire.com

MEXICO CITY, MEXICO / ACCESSWIRE / May 18, 2017 / Royal Holiday Vacation Club has won the ARDY, the top award for its sales training program called Royal Connect. Royal Connect was selected as the ARDY winner from scores of entries in the sales training category. Royal Holiday offers hundreds of videos in its online training program in the English language, but it also offers the same videos in Spanish and Portuguese. The American Resort Development Association (ARDA) honored the popular vacation club for its strong commitment to delivering each sales and marketing training video in three different languages. The well-respected company stands out in the international resort development community. Since it offers its customers the option to visit over 180 destinations in 52 countries, a multi-lingual and multi-cultural approach to its sales and marketing program is crucial to its ongoing success. For the second year in a row, the company was named as a finalist in four ARDA Award Categories in its annual ARDA Award Competition Program. The finalists are selected from hundreds of entries. Royal Holiday Vacation Club, founded in 1983, offers its members more than 180 Luxury Beach Resorts, Hotels around the world, fully equipped condos, as well as more than 3,000 different cruises. The points based vacation club membership operator and resort developer has approximately 110,000 members from 52 countries. Rosario Rodriguez Rojo, CEO of Royal Holiday Vacation Club, said, "We are particularly honored to accept the award as it speaks to our commitment to provide professional training to all of our Royal Club Hosts who are there to ensure wonderful vacation experiences for our members from the moment they first meet with us." In addition to the ARDY for Royal Connect, the company was named as a top contender in the following categories: Winners of the coveted "ARDY" Award were announced at the industry association's annual gathering, ARDA World 2017 at the Hyatt Regency in New Orleans on March 29. Royal Holiday Vacation Club is Mexico City-based timeshare vacation club that is proud to have over 100,000 members in 52 countries, and is committed to offering the highest standard in quality service in the best hotels, affiliated resorts, condos, villas, international timeshares and cruise ships. Because of the many destinations and vacation offerings it provides, this nominee can meet and satisfy any vacationer's needs year after year. Royal Holiday caters to every demographic (age, lifestyle, nationality, single, married, families) and offers 180 destinations from the US to Canada, to Mexico, to the Caribbean, to South America, to Europe and other continents. Royal Holiday not only offers timeshare, condo and hotel options, but also cruises in popular destinations. By positioning itself as a points-based vacation club, this nominee guarantees its customers that they will be able to experience any kind of vacation they want year after year by adapting to their personal needs as they change over time. By embracing a wide range of demographics, lifestyles, locations and vacation styles, Royal Holiday provides lifelong vacations to all of its members.


News Article | April 26, 2017
Site: www.prweb.com

According to the newly released 2016 U.S. Shared Vacation Ownership Consolidated Owners Report from the ARDA International Foundation (AIF), the timeshare industry remains healthy, showing that owners have become increasingly engaged with their timeshare and the timeshare lifestyle. In fact, there are currently about 9.2 million households in America that own a timeshare, with the average length of ownership being nine years. “There are countless reasons we continue to attract new buyers, but ultimately it breaks down to three core benefits,” says Howard Nusbaum, president and CEO of ARDA. “These owners love the location of their resort, they appreciate the value proposition that owning a timeshare provides and they know it will help ensure that they will take vacation every year.” Timeshare owners in the U.S. are ethnically diverse with 60% being White, 20% being African-American, and 14% Asian-American. They are also highly educated, with about 63% having at least a four-year college degree. The median household income for timeshare owners is $81,311, much higher than the median household income of $54K for the U.S. on average. Fifty-three percent of owners spent $10,000 or more on their timeshare. And when it came to buying a timeshare resort, nearly half of timeshare owners indicate that WiFi (48%) and restaurants (46%) matter the most to them in terms of convenience items at a timeshare resort. Once purchased, owners love their properties, in fact seven out of 10 owners would recommend timeshare ownership based upon their experience. And not only did they love their properties, they loved how easy their buying experience was. Over seven of 10 recent purchasers (71%) found their buying experience to be excellent or good. “This is a lifestyle that appeals to a wide demographic,” continues Nusbaum. “Our buyers are happy with their purchases and they want to share that enthusiasm.” Owners are devout vacationers, and on average, timeshare owners took more than three vacations in 2015. Nearly 60% of timeshare owners either used their timeshare personally or banked/deposited their timeshare in 2015 for later use. A large majority (77%) of timeshare owners took a vacation at a timeshare resort during 2015, a very promising sign. This positive feedback reflects the growth the industry is experiencing and should help propel the timeshare industry through the next few years. In fact, nearly half (48%) of all current timeshare owners plan to buy or upgrade a timeshare over the next two years. The report was conducted by Leger and commissioned by the ARDA International Foundation. For more details, see ARDA’s infographic and for a copy of the full study, visit http://www.arda.org/foundation.


News Article | December 22, 2016
Site: www.businesswire.com

BOSTON, Mass., IRVINE, Calif., & REHOVOT, Israel--(BUSINESS WIRE)--Tokai Pharmaceuticals Inc. (NASDAQ:TKAI) and Otic Pharma Ltd., a privately-held, clinical-stage pharmaceutical company focusing on the development and commercialization of products for disorders of the ear, nose, and throat (ENT), today announced that the two companies, together with the shareholders of Otic Pharma, have entered into a definitive share purchase agreement under which the shareholders of Otic Pharma will become the majority owners of Tokai. The transaction will result in a NASDAQ-listed company focused on the development and commercialization of products for ENT disorders, including Otic Pharma’s lead candidate which is a nasally-administered, combination drug product (OP-02) intended to address the underlying cause of otitis media and Eustachian tube dysfunction (OM/ETD), a condition that affects more than 700 million people around the world every year. The company will operate under the name OticPharma, Inc., and will be led by Gregory J. Flesher, current Chief Executive Office of Otic Pharma Ltd. Current President and Chief Executive Officer of Tokai, Jodie Morrison, will remain as a member of the board of directors. “Over the last several months, Tokai has conducted an extensive review of strategic alternatives aimed at maximizing value for our shareholders over the long-term,” said Jodie Morrison, President and CEO of Tokai Pharmaceuticals. “We believe the proposed transaction with Otic Pharma, a company that has both a promising pipeline and an experienced leadership team with a track record of creating significant shareholder value in public pharmaceutical companies, advances this goal.” “Our lead program in otitis media, OP-02, has significant potential,” said Gregory J. Flesher, Chief Executive Officer of Otic Pharma. “OP-02 is an investigational drug product designed to break the cycle of recurrent and chronic otitis media which affect millions of people around the world. We expect to have phase 1 clinical pharmacodynamic data in the first half of 2017 and, with this transaction, to have the capital needed to be able to move directly into phase 2 development to explore the product’s ability to prevent otitis media in children.” Under the terms of the agreement, the shareholders of Otic Pharma will receive a total of 32,172,209 shares of newly issued Tokai common stock, while outstanding Otic Pharma options and convertible securities will be assumed by Tokai. Upon the exchange, it is expected that existing Tokai stockholders will own approximately 40% of the combined company, with existing Otic Pharma shareholders owning approximately 60%. The transaction has been unanimously approved by the boards of directors of both companies and shareholders of Otic Pharma. Tokai’s largest stockholder, Apple Tree Partners, who holds approximately 35% of Tokai’s common stock has entered into an agreement in support of the proposed transaction. The transaction is expected to close during the first quarter of 2017, subject to customary closing conditions, including approval by shareholders of Tokai. Wedbush PacGrow advised Tokai Pharmaceuticals and Piper Jaffray & Co. advised Otic Pharma in the proposed transaction. Wilmer Cutler Pickering Hale and Dorr LLP and Gross, Kleinhendler, Hodak, Halevy, Greenberg & Co. served as legal counsel to Tokai and Gibson, Dunn & Crutcher LLP and Yigal Arnon & Co. served as legal counsel to Otic Pharma. Upon the close of the proposed transaction, the board of directors of the combined company will consist of seven members, three to be designated by Tokai and four to be designated by Otic Pharma. Officers of the new company will be Gregory J. Flesher, President and Chief Executive Officer; Christine G. Ocampo, Chief Financial and Compliance Officer; and Dr. Catherine C. Turkel, Chief Development Officer. An Otic Pharma investor syndicate, including current shareholders and members of the management team, has committed to invest $7 million of additional capital in connection with the share purchase agreement. Tokai and Otic Pharma will host a conference call in early January to discuss the proposed transaction. Call in information will be provided in a future press release. Otic Pharma is a clinical-stage pharmaceutical company focusing on the development and commercialization of products for disorders of the ear, nose, and throat (ENT). The company has two platform technologies, each of which has the potential to be developed for multiple ENT indications. The company is currently developing a nasally-administered, combination drug product (OP-02) intended to address the underlying cause of otitis media and Eustachian tube dysfunction (OM/ETD), a condition that affects more than 700 million people around the world every year. Otitis media is one of the most common disease seen in pediatric practice and the most frequent reason children consume antibiotics or undergo surgery. The company also has a foam-based drug delivery technology platform (OP-01) that can be used to deliver drugs into the ear, nose, and sinus cavities. The company is currently developing OP-01 as an improved treatment option for acute otitis externa (“swimmers ear”). For more information on the company, please visit www.oticpharma.com. Tokai Pharmaceuticals is a biopharmaceutical company previously focused on developing and commercializing innovative therapies for prostate cancer and other hormonally driven diseases. The ARMOR2 and ARMOR3-SV clinical trials of Tokai’s drug candidate, galeterone, for the treatment of metastatic castration-resistant prostate cancer (mCRPC) have been closed, with only patients in ARMOR2 long-term extension continuing treatment at this time. Plans remain in effect to present data from the ARMOR3-SV trial in a scientific forum once fully available and analyzed. Assessment of plans for galeterone, the ARDA platform and Tokai’s AR-V7 assay work are underway at this time. Additional Information about the Proposed Transaction and Where to Find It In connection with the proposed transaction, Tokai intends to file with the Securities and Exchange Commission (the “SEC”) a proxy statement in connection with the proposed transaction with Otic Pharma and furnish or file other materials with the SEC in connection with the proposed transaction. The definitive proxy statement will be sent or given to the stockholders of Tokai and will contain important information about the proposed transaction and related matters. BEFORE MAKING ANY VOTING DECISION, TOKAI’S STOCKHOLDERS ARE URGED TO READ THE PROXY STATEMENT AND THOSE OTHER MATERIALS (INCLUDING ANY AMENDMENTS OR SUPPLEMENTS THERETO) CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND THE PARTIES TO THE PROPOSED TRANSACTION. The proxy statement and other relevant materials (when they become available), and any other documents filed by Tokai with the SEC, may be obtained free of charge at the SEC’s website at www.sec.gov. In addition, security holders will be able to obtain free copies of the proxy statement upon request directed to the Corporate Secretary at 255 State Street, Boston MA 02109, or by phone at 617-225-4305. Tokai, Otic Pharma and each of their respective directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of Tokai in connection with the proposed transaction. Information regarding the interests of these directors and executive officers in the proposed transaction described herein will be included in the proxy statement described above. Additional information regarding the directors and executive officers of Tokai is included in proxy statement for its 2016 Annual Meeting, which was filed with the SEC on April 29, 2016, and is supplemented by other public filings made, and to be made, with the SEC by Tokai. Any statements in this press release that are not historical facts, including statements regarding the structure, timing and completion of the proposed transaction; Tokai’s continued listing on NASDAQ prior to and after the proposed transaction; expectations regarding the capitalization, cash balances and working capital, resources and ownership structure of the company after the transaction; expectations regarding the sufficiency of the company’s resources to fund the advancement of any development program or the completion of any clinical trial; the nature, strategy and focus of the company after the transaction; the safety, efficacy and projected development timeline and commercial potential of any product candidates; the expectations regarding voting by Tokai stockholders: and other statements containing the words “believes,” “anticipates,” “plans,” “expects,” “may,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: risks and uncertainties associated with stockholder approval of and the ability to consummate the proposed transaction; whether the anticipated cash resources will be sufficient to fund operations for the period anticipated and to conduct the anticipated studies; whether the necessary approvals to commence clinical trials of Otic’s product candidates can be obtained on a timely basis or at all; and whether the results of clinical trials will warrant submission for regulatory approval, any such submission will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies and, if any of such product candidates obtains such approval, it will be successfully distributed and marketed. Risks and uncertainties facing Tokai are discussed in the “Risk Factors” section of its quarterly report on Form 10-Q for the three months ended September 30, 2016 Any forward-looking statements contained in this press release speak only as of the date hereof and not of any future date, and the companies expressly disclaim any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.


News Article | February 15, 2017
Site: www.PR.com

Up for 10 Awards from the American Resort Development Association “Brand Tango is honored to be recognized in so many categories, from brochures to technology applications to immersive websites,” says James Kluetz, president and chief creative officer. “As the industry evolves to meet the needs of today’s consumers, we’ve expanded our capabilities to provide more digital branding and technology services. It’s a thrill to be a part of it.” The awards will be presented on March 29 at the 2017 ARDA World convention held by the American Resort Development Association at the Hyatt Regency in New Orleans. Brand Tango is the place where ideas, technology and brand expression are thoughtfully blended and served up daily. Brand Tango’s client list spans a wide range of industries including hospitality, vacation ownership, food and beverage, consumer products, financial services, and medical. Relying on their decades of combined expertise, the agency’s principals and staff help clients find solutions that deliver measurable results. Visit brandtango.com to learn more. Deerfield Beach, FL, February 14, 2017 --( PR.com )-- Brand Tango, an award-winning branding, design and digital agency located in South Florida, has had nine Advertising and Promotion entries selected as finalists in the American Resort Development Association’s 2017 ARDY awards competition. In addition, the Brand Tango creative team is also a finalist for an ARDY in the Graphic Design Professional or Team category. Up for top honors is work for Brand Tango clients VIA Destination Club, Grupo Questro’s Ritz-Carlton Reserve Residences, Sunset World, Unlimited Vacation Club by AMResorts, DAE, and Magic Development, along with Brand Tango’s own website.“Brand Tango is honored to be recognized in so many categories, from brochures to technology applications to immersive websites,” says James Kluetz, president and chief creative officer. “As the industry evolves to meet the needs of today’s consumers, we’ve expanded our capabilities to provide more digital branding and technology services. It’s a thrill to be a part of it.”The awards will be presented on March 29 at the 2017 ARDA World convention held by the American Resort Development Association at the Hyatt Regency in New Orleans.Brand Tango is the place where ideas, technology and brand expression are thoughtfully blended and served up daily. Brand Tango’s client list spans a wide range of industries including hospitality, vacation ownership, food and beverage, consumer products, financial services, and medical. Relying on their decades of combined expertise, the agency’s principals and staff help clients find solutions that deliver measurable results. Visit brandtango.com to learn more. Click here to view the list of recent Press Releases from Brand Tango


Barrut B.,ARDA | Blancheton J.-P.,French Research Institute for Exploitation of the Sea | Champagne J.-Y.,École Centrale Lyon | Grasmick A.,Montpellier University
Aquacultural Engineering | Year: 2012

In aquaculture, oxygen transfer and carbon dioxide stripping are the first limiting factors to fish rearing intensification. In this study we measured the O 2 and CO 2 mass transfer coefficient (K La) for a vacuum airlift in fresh (<1‰ salinity) and sea water (35‰ salinity) recirculating aquaculture systems (RAS). The airlift was composed of two concentric tubes: an inner riser tube and an external downcomer tube and can be adjusted at three different heights: 2, 4 or 6m. Several types of air injectors were tested, delivering different sizes of bubble swarms depending on their porosity and functioning conditions (low or high injection pressure), with air flows varying from 0 to 80Lmin -1. Experiments were also carried out at different water circulation velocities and with cold (7°C) and warm water (22°C). The best transfer coefficient (K La) value was obtained at a high air flow rate, a high temperature and with reduced bubble size. Results showed that K La was not affected by water salinity, but it was slightly affected by water flow (Q w), airlift inner pipe length and vacuum. The presence of vacuum reduces gas solubility in water and facilitates CO 2 stripping. The comparison between O 2 and CO 2 transfers showed that higher K La values were obtained for O 2 than for CO 2 in fresh and sea water, probably due to chemical reactions between the CO 2 and water. For RAS, the vacuum airlift provides a Standard Aeration Efficiency (SAE) of 1.13kgO 2kWh -1 and a Standard Stripping Efficiency (SSE) of 1.8kgO 2kWh -1 or 0.023kgCO 2kWh -1. In rearing water, CO 2 and O 2 transfers were negatively affected when feed was added. An empirical model for CO 2 mass transfer coefficient prediction was developed and calibrated. Simulation shows a good correlation between predicted and measured values (R 2=0.87). © 2011 Elsevier B.V.


Barrut B.,ARDA | Blancheton J.-P.,French Research Institute for Exploitation of the Sea | Callier M.,French Research Institute for Exploitation of the Sea | Champagne J.-Y.,École Centrale Lyon | Grasmick A.,Montpellier University
Aquacultural Engineering | Year: 2013

The accumulation of particulate organic matter (POM) in recirculating aquaculture systems (RAS) has become an important issue with the intensification of finfish production. The objective of this study was to assess the foam fractionation efficiency of a vacuum airlift in different conditions (POM concentrations, airflow rates, bubble sizes, water renewal rates and feed addition). In sea water, the vacuum airlift allowed removing 20% of the initial POM concentration per hour (foam fractionation efficiency), corresponding to a 20.7-fold concentration factor between the tank and the foam. In rearing conditions, efficiency increased with decreasing water renewal rate or increasing POM concentration. An increase in airflow rate from 10 to 80Lmin-1 in the vacuum airlift significantly decreased foam fractionation efficiency when feed was added to the water. The impact of feeding was only observed with high airflow rates where bubble coalescence occurred. Calculated POM production by fish ranged between 15.9 and 23.5gh-1 and was equivalent to estimations based on feed conversion ratio (FCR). This indicated that all the POM produced was extracted by the vacuum airlift. © 2012 Elsevier B.V..


PubMed | ARDA, Plateforme Technologique Of Resonance Magnetique Nucleaire Et Of Resonance Paramagnetique Electronique Of Luniversite Of Bretagne Occidentale, University of Southern Brittany and University of French Polynesia
Type: | Journal: Talanta | Year: 2016

In this study, we report the chemical characterization of 47 tropical microalgae and cyanobacteria by HR-MAS. The generated data confirm the interest of HR-MAS as a rapid screening technique with the major advantage of its easiness. The sample is used as powder of freeze-dried microalgae without any extraction process before acquisition. The spectral fingerprints of strains are then tested as variables for a chemotaxonomy study to discriminate cyanobacteria and dinoflagellates. The individual factor map generated by PCA analysis succeeds in separating the two groups, essentially thanks to the presence of specific carbohydrates. Furthermore, more resolved signals enable to identify many osmolytes. More precisely the characteristics of 2-O-alpha-D-glucosylglycerol (GG) are observed in all 21 h-MAS spectra of tropical cyanobacteria. After specific extraction, complementary analysis by 1D and 2D-NMR spectroscopies validates the identification of this osmolyte.


Taillebois L.,French Natural History Museum | Keith P.,French Natural History Museum | Valade P.,ARDA | Torres P.,French Natural History Museum | And 3 more authors.
General and Comparative Endocrinology | Year: 2011

After oceanic migration, post-larvae of the amphidromous Sicyopterus lagocephalus recruit to rivers in Reunion Island. As they enter the river mouth, post-larvae undergo many morphological, physiological and behavioural changes. These drastic changes, which allow them to change feeding regime and to colonise the juvenile and adult freshwater habitat, are defined as metamorphosis. The endocrine control of these changes has never been investigated in Gobioid fish. Here, we investigated whether thyroid hormones (TH) influence metamorphosis in recruiting S.lagocephalus. An analytical study was first performed on a cohort of 2400 fish caught at post-larval stage 1 and maintained for 37days after capture in a flume tank (fluvarium), which replicates as closely as possible the natural conditions. Biometrical parameters (total and standard lengths, corner of mouth angle, body mass and condition factor) and whole-body thyroxine (T 4) and triiodothyronine (T 3) contents were measured on fish, sampled at regular intervals during these 37days (192 fish). TH levels, measured by radioimmunoassays, were highest when morphological changes, such as the change in the position of the mouth, were most important. An experimental approach was then used to test the effect of the hormonal treatment (T 4 or thiourea, TU, a TH inhibitor) on biometrical parameters of 576 post-larvae. The change in the position of the mouth was significantly accelerated in the T 4-treated post-larvae, while it was significantly delayed in the TU-treated post-larvae, compared to controls. Our study suggests that S.lagocephalus post-larva undergoes a true metamorphic event under the control of thyroid hormones at the time of its recruitment into the river. © 2011 Elsevier Inc.

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