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Mandato V.D.,Arcispedale Santa Maria Nuova di Reggio Emilia | Magnani E.,Unit of Oncology | Abrate M.,Arcispedale Santa Maria Nuova di Reggio Emilia | Casali B.,Laboratory of Molecular Biology | And 10 more authors.
Anticancer Research | Year: 2012

Background: Haptoglobin (H) is a glycoprotein that regulates the immune response. Serum haptoglobin levels are significantly higher in patients with advanced epithelial ovarian cancer (EOC) with poor survival. Different isoforms of haptoglobin have been found in the serum of patients with EOC. We studied the genetic susceptibility and outcome of patients with EOC correlated to H phenotypes. Materials and Methods: Analyses of the H phenotypes were performed on sera from patients stored at -70°C. A modified method based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of sera was used, followed by western blotting. Results: Seventy-nine consecutive patients with EOC and 63 healthy women were enrolled. Their mean (±S.D.) age was 58.9±12.46 years. Overall survival was 66 months (95% confidence interval=37.7-94.2). Similar distribution of haptoglobin phenotypes was observed in EOC and in healthy women. No significant correlation was found between haptoglobin phenotype, overall survival and time-to- progression. Fewer G3 tumors were found in patients with H2-2 compared with those with H1-2 (84.2% and 90.6%, respectively, p<0.04). No significant correlation was found between H phenotype and tumor markers or number of relapses. Conclusion: Although ours is a preliminary study based on a small population with scant significant findings, we hypothesize that patients with EOC with haptoglobin 2-2, might have a better prognosis because they present fewer G3 tumors and they may present a stronger immune response than patients with 1-1 and 1-2 phenotypes. Larger studies should be performed to assess the predictive value of haptoglobin phenotype in patients with EOC.


Mangone L.,Quality and Clinical Studies Unit | Mandato V.D.,Arcispedale Santa Maria Nuova di Reggio Emilia | Gandolfi R.,Association La Melagrana | Tromellini C.,Association La Melagrana | Abrate M.,Arcispedale Santa Maria Nuova di Reggio Emilia
European Journal of Gynaecological Oncology | Year: 2014

Purpose of investigation: To describe the experience of ovarian cancer patients from symptoms complained before diagnosis until the impact of ovarian cancer diagnosis perceived by women. Materials and Methods: The authors used the Psychological General Well being Index (PGWBI) and a semi-structured interview to measure the overall well being of 39 women diagnosed with ovarian cancer in the period 2005-2010 at a secondary care hospital in northern Italy. Results: The PGWBI showed that the majority of the women reported general stress. On the semi-structured interview, 95% of women reported having symptoms and 69% reported a stressful event prior to diagnosis. More than 50% of women reported changes concerning life course. Almost all reported that their primary concerns had to do with the surgical scar, weight gain, and hair loss. Conclusions: Ovarian cancer diagnosis has a very stressful effect on the quality of life. Early assessment of psychological problems must be an integral part of the therapeutic pathway. Gynaecologists must provide clear and useful information regarding the disease itself as well as regarding correlated symptom relief.


PubMed | Arcispedale Santa Maria Nuova di Reggio Emilia
Type: Journal Article | Journal: Anticancer research | Year: 2012

Haptoglobin (H) is a glycoprotein that regulates the immune response. Serum haptoglobin levels are significantly higher in patients with advanced epithelial ovarian cancer (EOC) with poor survival. Different isoforms of haptoglobin have been found in the serum of patients with EOC. We studied the genetic susceptibility and outcome of patients with EOC correlated to H phenotypes.Analyses of the H phenotypes were performed on sera from patients stored at -70C. A modified method based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of sera was used, followed by western blotting.Seventy-nine consecutive patients with EOC and 63 healthy women were enrolled. Their mean ( S.D.) age was 58.9 12.46 years. Overall survival was 66 months (95% confidence interval=37.7-94.2). Similar distribution of haptoglobin phenotypes was observed in EOC and in healthy women. No significant correlation was found between haptoglobin phenotype, overall survival and time-to-progression. Fewer G3 tumors were found in patients with H2-2 compared with those with H1-2 (84.2% and 90.6%, respectively, p<0.04). No significant correlation was found between H phenotype and tumor markers or number of relapses.Although ours is a preliminary study based on a small population with scant significant findings, we hypothesize that patients with EOC with haptoglobin 2-2, might have a better prognosis because they present fewer G3 tumors and they may present a stronger immune response than patients with 1-1 and 1-2 phenotypes. Larger studies should be performed to assess the predictive value of haptoglobin phenotype in patients with EOC.

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