Reichel C.,ARC Seibersdorf Research
Handbook of Experimental Pharmacology | Year: 2010
Erythropoietin (EPO), a glycoprotein hormone, stimulates the growth of red blood cells and as a consequence it increases tissue oxygenation. This performance enhancing effect is responsible for the ban of erythropioetin in sports since 1990. Especially its recombinant synthesis led to the abuse of this hormone, predominatly in endurance sports. The analytical differentiation of endogenously produced erythropoietin from its recombinant counterpart by using isoelectric focusing and double blotting is a milestone in the detection of doping with recombinant erythropoietin. However, various analogous of the initial recombinant products, not always easily detectable by the standard IEF-method, necessitate the development of analytical alternatives for the detection of EPO doping. The following chapter summarizes its mode of action, the various forms of recombinant erythropoietin, the main analytical procedures and strategies for the detection of EPO doping as well as a typical case report. © 2009 Springer-Verlag Berlin Heidelberg.
Ucsnik S.,LKR Leichtmetallkompetenzzentrum Ranshofen GmbH |
Scheerer M.,ARC Seibersdorf Research |
Zaremba S.,FACC AG |
Pahr D.H.,Vienna University of Technology
Composites Part A: Applied Science and Manufacturing | Year: 2010
An integrative joining technology between steel and carbon fibre-reinforced plastics (CFRP) is presented for lightweight design applications in aviation industries. Small spikes are welded onto metal surfaces via "cold-metal transfer" which then build up a fibre-friendly fixation through form-closure with co-cured composites. Manufacture of such reinforced hybrid specimens and results of static tensile testings are discussed. Video-extensometry is applied to characterize the hybrid joints in terms of strength and failure history. Comparisons with epoxy bonded references show improvements in ultimate load, maximum deformation and energy absorption capacity. © 2009 Elsevier Ltd. All rights reserved.
Cheng M.,Beijing University of Chemical Technology |
Gao H.,Beijing University of Chemical Technology |
Zhang Y.,Johannes Gutenberg University Mainz |
Tremel W.,Beijing University of Chemical Technology |
And 3 more authors.
Langmuir | Year: 2011
The formation of ordered complex structures is one of the most challenging fields in the research of biomimic materials because those structures are promising with respect to improving the physical and mechanical properties of man-made materials. In this letter, we have developed a novel approach to fabricating complex structures on the mesoscale by combining magnetic-field-induced locomotion and supramolecular-interaction-assisted immobilization. We have employed a magnetic field to locomote the glass fiber, which was modified by the layer-by-layer self-assembly of magnetic nanoparticles, to desired positions and have exploited the supramolecular interaction to immobilize glass fiber onto the appointed position. By magnetically induced micromanipulation, we can drive another fiber across the former one and finally obtain a crossing structure, which can lead to more complex structures on the mesocale. Moreover, we have constructed a mesoscale structure, termed "CHEM", to demonstrate further the application of this method. © 2011 American Chemical Society.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.8.5 | Award Amount: 1.63M | Year: 2009
The goal of the eMorph project is to design asynchronous vision sensors with non-uniform morphology, using analog VLSI neuromorphic circuits, and to develop a supporting data-driven asynchronous computational paradigm for machine-vision that is radically different from conventional image processing. The mainstream computational paradigm in embodied intelligence is digital and it is clear that conventional digital systems have difficulties in performing robustly even in the most mundane tasks of perception. They require vast amounts of resources to extract relevant information, but still fail to produce appropriate responses for interacting with the real-world in real time. In addition, in sensory perception tasks, the data acquired from the sensors is typically noisy and ambiguous. Frame-based time sampling and quantization artifacts present in conventional sensors are particularly problematic for robust and reliable performance. The situation is clearly different in biological systems. In particular, biological neural systems vastly outperform conventional digital machines in almost all aspects of sensory perception tasks. Despite its dramatic progress, information technology has not yet been able to deliver artificial systems that can compare with biology. There are limitations both at the technological level, and at the theoretical/computational level. Analog computation - free from the limits of sampling - provides a solution. Analog devices are fast, as time constants are in the range of the rising time of the transistor currents. Event-driven computation intrinsically adapts the sensor response to the time constants of the real world. The sensor response is automatically regulated to match the incoming signal range, and so is robust. Moreover as only important events are coded, they are also efficient. The eMorph project thus aims to design novel, data-driven, biologically inspired, analog sensory devices while also developing new asynchronous event-driven computational paradigms for them. eMorph aims to adapt the computational engine of the cognitive system (its morphology with respect to computation) to the dynamics of the real world rather than furiously sample the physical sensory signals in an attempt to obtain adequate bandwidth. Structure and morphology will be matched to the requirements of the robots body and its application domain with testing to be carried out on the advanced humanoid robotic platform, iCub (project RobotCub, http://www.robotcub.org). The project will assemble a small but focused team of researchers from European leading institutions with well balanced complementary skills around these common goals.
Montealegre Melendez I.,ARC Seibersdorf Research |
Neubauer E.,ARC Seibersdorf Research |
Angerer P.,CEST Center Of Electrochemical Surface Technology |
Danninger H.,Vienna University of Technology |
Torralba J.M.,Charles III University of Madrid
Composites Science and Technology | Year: 2011
The goal of this work is the evaluation of nanoscaled reinforcements; in particular nanodiamonds (NDs) and carbon nanotubes (CNTs) on properties of titanium matrix composites (TiMMCs). By using nano sized materials as reinforcement in TiMMCs, superior mechanical and physical properties can be expected. Additionally, titanium powder metallurgy (P/M) offers the possibility of changing the reinforcement content in the matrix within a very wide range. In this work, TiMMCs have been produced from titanium powder (Grade 4). The manufacturing of the composites was done by hot pressing, followed by the characterisation of the TiMMCs. The Archimedes density, hardness and oxygen content of the specimens in addition to the mechanical properties were compared and reported in this work. Moreover, XRD analysis and SEM observations revealed in situ formed titanium carbide (TiC) phase after hot pressing in TiMMCs reinforced with NDs and CNTs, at 900 °C and 1100 °C respectively. The strengthening effect of NDs was more significant since its distribution was more homogeneous in the matrix. © 2011 Elsevier Ltd.