Arasto Pharmaceutical Chemicals Inc

Tehrān, Iran

Arasto Pharmaceutical Chemicals Inc

Tehrān, Iran
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Heli H.,Islamic Azad University at Science and Research of Fars | Mirtorabi S.,Avicenna Laboratories Inc. | Karimian K.,Arasto Pharmaceutical Chemicals Inc.
Expert Opinion on Therapeutic Patents | Year: 2011

Introduction: Oxidative stress (caused by excess iron) can result in tissue damage, organ failure and finally death, unless treated by iron chelators. The causative factor in the etiology of a variety of disease states is the presence of iron-generated reactive oxygen species (ROS), which can result in cell damage or which can affect the signaling pathways involved in cell necrosis-apoptosis or organ fibrosis, cancer, neurodegeneration and cardiovascular, hepatic or renal dysfunctions. Iron chelators can reduce oxidative stress by the removal of iron from target tissues. Equally as important, removal of iron from the active site of enzymes that play key roles in various diseases can be of considerable benefit to the patients. Areas covered: This review focuses on iron chelators used as therapeutic agents. The importance of iron in oxidative damage is discussed, along with the three clinically approved iron chelators. Expert opinion: A number of iron chelators are used as approved therapeutic agents in the treatment of thalassemia major, asthma, fungal infections and cancer. However, as our knowledge about the biochemistry of iron and its role in etiologies of seemingly unrelated diseases increases, new applications of the approved iron chelators, as well as the development of new iron chelators, present challenging opportunities in the areas of drug discovery and development. © 2011 Informa UK, Ltd.

Heli H.,Institute of Mechanics | Zare S.N.,Islamic Azad University | Sattarahmady N.,Shiraz University of Medical Sciences | Karimian K.,Arasto Pharmaceutical Chemicals Inc
Current Pharmaceutical Analysis | Year: 2013

The electrochemical behavior of sotalol was investigated on a graphene oxide nanosheets-modified glassy carbon electrode in a phosphate buffer solution, pH 7.4. Cyclic voltammetry and chronoamperometry were employed to obtain information about the electrooxidation process. During the electrooxidation of sotalol, one irreversible anodic peak appeared in the voltammograms. Some kinetic parameters, such as the diffusion and charge transfer coefficients were obtained. An amperometric procedure was developed for the determination of sotalol, a detection limit of 7.57 μM, a linear dynamic range of 0.1 to 2.24 mM, and a calibration sensitivity of 0.945 mA M-1 were obtained. The method was applied to the analysis of sotalol tablets, and applicability of the method to direct assays of spiked human serum and urine fluids was investigated. © 2013 Bentham Science Publishers.

Sattarahmady N.,Shiraz University of Medical Sciences | Heli H.,Shiraz University of Medical Sciences | Moosavi-Movahedi A.A.,University of Tehran | Karimian K.,Arasto Pharmaceutical Chemicals Inc.
Molecular Biology Reports | Year: 2014

Diabetic complication arises from the presence of advanced glycation end products in different sites of the body. Great attention should be paid to recognizing anti-glycation compounds. Here, deferiprone as an oral iron chelator drug administrated in treatment of β-thalassemic patients was selected to find its effect on the fructation of hemoglobin (Hb). Our results indicated that deferiprone could prevent the AGE and carbonyl formation via inhibition of structural changes in the structure of Hb during the fructation process. Moreover, deferiprone can preserve peroxidase and esterase activities of fructated Hb similar to native Hb. Therefore, deferiprone can be introduced as an anti-glycation drug to prevent the AGE formation. © 2014 Springer Science+Business Media.

Heli H.,Shiraz University of Medical Sciences | Sattarahmady N.,Shiraz University of Medical Sciences | Vais R.D.,Shiraz University of Medical Sciences | Karimian K.,Arasto Pharmaceutical Chemicals Inc.
Sensors and Actuators, B: Chemical | Year: 2014

Nickel hydroxide nanopetals were synthesized by a simple hydrothermal method in one step in the presence of arginine as shape directing and pH adjusting agent. The nanopetals were then employed as the modifier of a carbon paste electrode. The kinetics of the charge transfer across the modified electrode/solution interface was studied and the modified electrode was employed to fabricate an amperometric sensor of montelukast. The mechanism and kinetics of the electrocatalytic oxidation of montelukast on the modified electrode surface, as a mediated electron transfer process by the high valence nickel species, were studied by cyclic voltammetry and chronoamperometry. An amperometric method was developed for determination of montelukast with a sensitivity of 36.54 mA mol-1 L cm-2 and a limit of detection of 8.9 μmol L-1. The method was used for the direct assay of montelukast in human serum samples and montelukast tablets. The sensor had the advantages of high electrocatalytic activity and sensitivity, and long-term stability toward montelukast. © 2014 Elsevier B.V.

Heliab H.,Islamic Azad University at Marvdasht | Yadegaric H.,K. N. Toosi University of Technology | Karimiand K.,Arasto Pharmaceutical Chemicals Inc
Journal of Experimental Nanoscience | Year: 2011

The synthesis of nanoflakes of cobalt oxide via electrodeposition onto platinum electrode surface was reported. The morphology of the electrodeposited thin film was studied by means of scanning electron microscopy and atomic force microscopy techniques and the electrochemical characteristics were investigated using cyclic voltammetry. The applicability of the synthesised nanoflakes of cobalt oxide to electrocatalytic oxidation of two orally administered iron chelating drugs (deferasirox, ICL670 and deferiprone, CP20) was evaluated in an alkaline solution. The results indicate that the drugs were oxidized via oxyhydroxide species immobilised on the electrode surface through an electrocatalytic mechanism. The catalytic rate constants and the diffusion coefficients of the drugs were determined. A sensitive, simple and efficient amperometric procedure was developed for the analysis of deferasirox and deferiprone, with detection limits of 6.67 and 2.52 μM, respectively. The electrode was also used for the direct assay of deferasirox and deferiprone tablets and determination of their main metabolites in human serum and urine. © 2011 Taylor & Francis.

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