Arak, Iran

Arak University of Medical science is a medical science university in Arak, Iran. Wikipedia.


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Moini A.,Arak University of Medical Sciences | Azimi G.,Shahed University | Farivar A.,Arak University of Medical Sciences
Allergy, Asthma and Immunology Research | Year: 2012

Purpose: Statins are known as cholesterol-lowering agents, but have been suggested for the treatment of asthma because of their anti-inflammatory effects. In this study, the potential therapeutic effects of atorvastatin were investigated in asthmatic patients. Methods: A total of 62 patients with persistent mild to moderate asthma who presented at asthma clinics of Arak University of Medical Sciences were recruited in a double-blind randomized clinical trial. The asthma clinical control score was assessed based on the standardized Asthma Control Test. Lung volume, i.e., percentage of forced expiratory volume in one second (FEV1%) and percentage of forced vital capacity (FVC%), and peripheral blood eosinophils were also measured. The intervention group was treated with atorvastatin 40 mg per day for 8 weeks, while the control group received a placebo. Asthma controller treatments were not changed. At the beginning and end of the study, serum cholesterol and triglyceride levels were measured to evaluate adherence of the patients to the treatment. Results: The asthma control score did not significantly differ between the intervention and control groups (P=0.06). Difference in FEV1%, FVC%, and blood eosinophil count between the intervention and control groups were not statistically significant (P>0.05). The differences in post-treatment cholesterol and low-density lipoprotein cholesterol levels were significant (P<0.05). Conclusions:Our study shows that atorvastatin is not effective in the treatment of persistent mild to moderate asthma. © The Korean Academy of Asthma, Allergy and Clinical Immunology.


Asemi Z.,Research Center for Biochemistry and Nutrition in Metabolic Diseases | Hashemi T.,Kashan University of Medical Sciences | Karamali M.,Arak University of Medical Sciences | Samimi M.,Kashan University of Medical Sciences | Esmaillzadeh A.,Isfahan University of Medical Sciences
American Journal of Clinical Nutrition | Year: 2013

Background: To our knowledge, there is no study that has examined the effects of vitamin D supplementation on metabolic status in gestational diabetes mellitus (GDM). Objective: This study was designed to assess the effects of vitamin D supplementation on metabolic profiles, high-sensitivity C-reactive protein, and biomarkers of oxidative stress in pregnant women with GDM. Design: This randomized, double-blind, placebo-controlled clinical trial was conducted in 54 women with GDM. Subjects were randomly assigned to receive either vitamin D supplements or placebo. Individuals in the vitamin D group (n = 27) received capsules containing 50,000 IU vitamin D3 2 times during the study (at baseline and at day 21 of the intervention) and those in the placebo group (n = 27) received 2 placebos at the same times. Fasting blood samples were collected at baseline and after 6 wk of the intervention to quantify relevant variables. Results: Cholecalciferol supplementation resulted in increased serum 25-hydroxyvitamin D concentrations compared with placebo (+18.5 ± 20.4 compared with +0.5 ± 6.1 ng/mL; P < 0.001). Furthermore, intake of vitamin D supplements led to a significant decrease in concentrations of fasting plasma glucose (-17.1 ± 14.8 compared with -0.9 ± 16.6 mg/dL; P < 0.001) and serum insulin (-3.08 ± 6.62 compared with +1.34 ± 6.51 μIU/mL; P = 0.01) and homeostasis model of assessment-insulin resistance (-1.28 ± 1.41 compared with +0.34 ± 1.79; P < 0.001) and a significant increase in the Quantitative Insulin Sensitivity Check Index (+0.03 ± 0.03 compared with -0.001 ± 0.02; P = 0.003) compared with placebo. A significant reduction in concentrations of total (-11.0 ± 23.5 compared with +9.5 ± 36.5 mg/dL; P = 0.01) and low-density lipoprotein (LDL) (-10.8 ± 22.4 compared with +10.4 ± 28.0 mg/dL; P = 0.003) cholesterol was also seen after vitamin D supplementation. Conclusions: Vitamin D supplementation in pregnant women with GDM had beneficial effects on glycemia and total and LDL-cholesterol concentrations but did not affect inflammation and oxidative stress. This trial was registered at www.irct.ir as IRCT201305115623N7. Am J Clin Nutr 2013;98:1425-32. © 2013 American Society for Nutrition.


Jamilian M.,Arak University of Medical Sciences | Asemi Z.,Kashan University of Medical Sciences
Journal of Clinical Endocrinology and Metabolism | Year: 2016

Context: Limited data are available evaluating the effects of soy isoflavones on metabolic status of patients with polycystic ovary syndrome (PCOS). Objective: The current study was performed to determine the effects of soy isoflavones on metabolic status of patients with PCOS. Methods: This randomized, double-blind, placebo-controlled trial was performed on 70 women diagnosed with PCOS according to the Rotterdam criteria who were 18-40 years old. Participants were randomly allocated into two groups to take either 50 mg/d soy isoflavones (n=35) or placebo (n = 35) for 12 weeks. Metabolic, endocrine, inflammation, and oxidative stress biomarkers were quantified at the beginning of the study and after the 12-week intervention. Results: After 12 weeks of intervention, compared to the placebo group, soy isoflavone administration significantly decreased circulating serum levels of insulin (-1.2±4.0 vs+2.8±4.7 μIU/mL; P < .001) and homeostasis model of assessment-estimated insulin resistance (-0.3 ± 1.0 vs +0.6 ± 1.1; P < .001) and increased the quantitative insulin sensitivity check index (+0.0009 ± 0.01 vs +0.01 ± 0.03; P = .01). Supplementation with soy isoflavones resulted in significant reductions in free androgen index (-0.03±0.04 vs+0.02±0.03; P=.001) and serum triglycerides (-13.3±62.2 vs +10.3 ± 24.5 mg/dL; P = .04) compared to the placebo group. There was a significant increase in plasma total glutathione (+96.0 ± 102.2 vs +22.7 ± 157.8 μmol/L; P = .04) and a significant decrease in malondialdehyde levels (-0.7 ± 0.8 vs +0.8 ± 2.3 μmol/L; P = .001) by soy isoflavone intake compared with the placebo group. We did not observe any significant effect of soy isoflavone intake on other lipid profiles and inflammatory and oxidative stress markers. Conclusion: Soy isoflavone administration for 12 weeks in women with PCOS significantly improved markers of insulin resistance, hormonal status, triglycerides, and biomarkers of oxidative stress.


Jamilian M.,Arak University of Medical Sciences | Asemi Z.,Kashan University of Medical Sciences
Annals of Nutrition and Metabolism | Year: 2015

Background: The aim of the present study was to evaluate the beneficial effects of chromium intake on markers of insulin metabolism and lipid profiles in women with polycystic ovary syndrome (PCOS). Methods: In a prospective, randomized, double-blind, placebo-controlled trial, 64 women with PCOS were randomized to receive 200 μg chromium picolinate supplements (n = 32) or placebo (n = 32) for 8 weeks. Fasting blood samples were obtained at baseline and 8 weeks after the intervention to quantify markers of insulin metabolism and lipid concentrations. Results: Chromium supplementation in women with PCOS resulted in significant decreases in serum insulin levels (-3.6 ± 7.4 vs. +3.6 ± 6.2 μIU/ml, p < 0.001), homeostasis model of assessmentinsulin resistance (HOMA-IR; -0.8 ± 1.6 vs. +0.9 ± 1.5, p < 0.001), homeostatic model assessment-beta cell function (HOMA-B; -15.5 ± 32.3 vs. +13.6 ± 23.1, p < 0.001), and a significant increase in quantitative insulin sensitivity check index (QUICKI) score (+0.02 ± 0.03 vs. -0.008 ± 0.02, p = 0.001) compared with the placebo. In addition, a trend toward a significant effect of chromium supplementation on decreasing serum triglycerides (-12.4 ± 74.4 vs. +15.2 ± 32.4 mg/dl, p = 0.05), very low-density lipoprotein-cholesterol (-2.5 ± 14.9 vs. +3.0 ± 6.5 mg/dl, p = 0.05), and cholesterol concentrations (-8.6 ± 21.9 vs. +0.7 ± 22.4 mg/dl, p = 0.09) was seen. Conclusions: Eight weeks of chromium supplementation among PCOS women had favorable effects on markers of insulin metabolism. © 2015 S. Karger AG, Basel.


Samimi M.,Kashan University of Medical Sciences | Jamilian M.,Arak University of Medical Sciences | Asemi Z.,Kashan University of Medical Sciences | Esmaillzadeh A.,Isfahan University of Medical Sciences
Clinical Nutrition | Year: 2015

Background & aims: We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 56 women with GDM. Subjects were randomly assigned to receive either 1000mg omega-3 fatty acid supplements containing 180mg eicosapentaenoic acid and 120mg docosahexanoic acid (n=28) or placebo (n=28) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables. Results: Although omega-3 fatty acid supplementation did not led to a significant change in serum insulin levels and HOMA-IR in omega-3 fatty acid group, we found a significant difference in changes in serum insulin levels (change from baseline:-1.5±7.5 vs.+3.5±8.5μIU/mL, P=0.02) and HOMA-IR (-0.4±2.1 vs.+1.1±2.4, P=0.02) comparing the two groups. Furthermore, a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) levels was seen after omega-3 fatty acid supplementation compared with placebo (-236.3±1541.9 vs. 898.6±2292.7ng/mL, P=0.03). Omega-3 fatty acid supplementation did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI) and lipid profiles. Conclusions: Omega-3 fatty acid supplementation in GDM women had beneficial effects on insulin resistance, however, it did not affect plasma glucose, HOMA-B, QUICKI and lipid profiles. Clinical registration number: www.irct.ir as IRCT201312265623N16. © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.


Talaei A.,Arak University of Medical Sciences | Mohamadi M.,Arak University of Medical Sciences | Adgi Z.,Arak University of Medical Sciences
Diabetology and Metabolic Syndrome | Year: 2013

Introduction. Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including type2 diabetes mellitus (T2DM). Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity. This study evaluates the effects of vitamin D supplementation on insulin resistance in T2DM. Method. Through a before-after study, 100 patients with T2DM, 30-70 years old, were recruited from an Arak diabetes clinic as consecutive attenders. Participants were assessed for clinical and biochemistry. Serum insulin and, 25(OH)D concentration, and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Patients received 50,000 unit of vitamin D§ssub§ 3 §esub§ orally per week for eight weeks, Statistical analysis was made using SPSS17. The results were analyzed by descriptive tests, and a comparison between variables were made using paired T-tests or Wilcoxon tests, as appropriate. Results: 100 participants including 70 women (70%) and 30 men (30%) took part in the study. All results were presented as Mean±SD, or medians of non-normally distributed.24% of the participants were Vitamin D deficient {serum 25(OH)D ≤ 20 ng/ml(50 nmol/l)}.Mean serum 25 (OH) D concentration was 43.03± 19.28 ng/ml (107.5±48.2 nmol/l).The results at baseline and at the end, for FPG were 138.48±36.74 and 131.02±39 mg/dl (P=0.05), for insulin, 10.76±9.46 and 8.6±8.25 μIu/ml (P=0.028) and for HOMA-IR, 3.57±3.18 and 2.89±3.28 (P=0.008) respectively. Conclusion: Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM. © 2013 Talaei et al; licensee BioMed Central Ltd.


Darvishi Cheshmeh Soltani R.,Arak University of Medical Sciences | Khataee A.R.,University of Tabriz | Safari M.,Kurdistan University of Medical Sciences | Joo S.W.,Yeungnam University
International Biodeterioration and Biodegradation | Year: 2013

The aim of this study was to evaluate the efficiency of immobilized nanosized bio-silica (average crystalline size of 20nm) within chitosan as a nanocomposite adsorbent for removing Acid Red 88 (AR88) in aqueous phase. As result, the amount of adsorbed AR88 (mgg-1) was increased with increasing reaction time and adsorbate concentration and decreasing temperature and initial pH. A rapid increment in the adsorption was happened with increasing adsorbent dosage from 1 to 3gl-1, while further increment in the adsorbent dosage resulted in an insignificant increase in the adsorption (1.66mgg-1). The kinetic study was performed and the results indicated the suitability of pseudo-second order kinetic model (R2=0.994). Besides, the correlation coefficient of Elovich model confirmed chemical nature of the adsorption (R2=0.9756). The fitness of experimental data to the intra-particle diffusion model demonstrated that the adsorption process occurred via a multi-step mechanism. But, the intra-particle diffusion was not the sole rate-limiting stage. According to the Langmuir isotherm model (R2=0.9962), the maximum adsorption capacity of bio-silica/chitosan nanocomposite for sequestering AR88 was about 25.84mgg-1. In addition, negative δG° and δH° values obtained through thermodynamic study indicated that the adsorption of AR88 onto nanocomposite was simultaneous and exothermic in nature, respectively. © 2013 Elsevier Ltd.


Darvishi Cheshmeh Soltani R.,Arak University of Medical Sciences | Rezaee A.,Tarbiat Modares University | Khataee A.,University of Tabriz
Industrial and Engineering Chemistry Research | Year: 2013

The aim of this work was to enhance the efficiency of a photocatalytic process involving carbon black (CB)-modified ZnO nanoparticles using an electrochemical process consisting of powdered activated carbon (PAC), carbon nanotubes (CNTs), and CB-polytetrafluoroethylene (PTFE)-coated gas-diffusion cathode (GDC) to degrade Acid Red 18. Hydrogen peroxide generated by PAC-PTFE-, CNT-PTFE-, and CB-PTFE-coated GDC was 58.45, 100.9, and 112.3 μM, respectively. The efficiency of the combined process equipped with CB-PTFE-coated GDC was assessed as the function of different operational parameters. With the increase of initial pH from 3 to 10, decolorization efficiency decreased from 94.5% to 57.61%. Increasing the dye concentration from 2 to 20 mg/L led to a decrease in the decolorization efficiency from 100% to 50.45%. The increase of the current intensity from 30 to 300 mA resulted in increasing decolorization efficiency from 37.45% to 95.31%. TOC analysis showed 51.13% mineralization of 10 mg/L dye solution in 20 min. © 2013 American Chemical Society.


Asemi Z.,Kashan University of Medical Sciences | Karamali M.,Arak University of Medical Sciences | Esmaillzadeh A.,Isfahan University of Medical Sciences
Diabetologia | Year: 2014

Aims/hypothesis: This study was designed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus (GDM). Methods: This randomised placebo-controlled trial was performed at maternity clinics affiliated to Kashan University of Medical Sciences, Kashan, Iran. Participants were 56 women with GDM at 24-28 weeks' gestation (18 to 40 years of age). Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. All study participants were blinded to group assignment. Individuals in the calcium-vitamin D group (n = 28) received 1,000 mg calcium per day and a 50,000 U vitamin D3 pearl twice during the study (at study baseline and on day 21 of the intervention), and those in the placebo group (n = 28) received two placebos at the mentioned times. Fasting blood samples were taken at study baseline and after 6 weeks of intervention. Results: The study was completed by 51 participants (calcium-vitamin D n = 25, placebo n = 26). However, as the analysis was based on an intention-to-treat approach, all 56 women with GDM (28 in each group) were included in the final analysis. After the administration of calcium plus vitamin D supplements, we observed a significant reduction in fasting plasma glucose (-0.89 ± 0.69 vs +0.26 ± 0.92 mmol/l, p < 0.001), serum insulin levels (-13.55 ± 35.25 vs +9.17 ± 38.50 pmol/l, p = 0.02) and HOMA-IR (-0.91 ± 1.18 vs +0.63 ± 2.01, p = 0.001) and a significant increase in QUICKI (+0.02 ± 0.03 vs -0.002 ± 0.02, p = 0.003) compared with placebo. In addition, a significant reduction in serum LDL-cholesterol (-0.23 ± 0.79 vs +0.26 ± 0.74 mmol/l, p = 0.02) and total cholesterol: HDL-cholesterol ratio (-0.49 ± 1.09 vs +0.18 ± 0.37, p = 0.003) and a significant elevation in HDL-cholesterol levels (+0.15 ± 0.25 vs -0.02 ± 0.24 mmol/l, p = 0.01) was seen after intervention in the calcium-vitamin D group compared with placebo. In addition, calcium plus vitamin D supplementation resulted in a significant increase in GSH (+51.14 ± 131.64 vs -47.27 ± 203.63 μmol/l, p = 0.03) and prevented a rise in MDA levels (+0.06 ± 0.66 vs +0.93 ± 2.00 μmol/l, p = 0.03) compared with placebo. Conclusions/interpretation: Calcium plus vitamin D supplementation in women with GDM had beneficial effects on their metabolic profile. Trial registration: www.irct.ir IRCT201311205623N11 Funding: The study was supported by a grant (no. 92110) from Kashan University of Medical Sciences. © 2014 Springer-Verlag Berlin Heidelberg.


Hezaveh M.S.,Arak University of Medical Sciences
Global journal of health science | Year: 2014

Unpreparedness of novice nurses during the process of transition to their professional role can has broad consequences for the nurse and health care system and leads to reduction of the quality of patient care. This study has been carried out with the aim of investigating the experiences of the unpreparedness of novice nurses. This study was conducted qualitatively by using conventional content analysis. Participants were 21 persons including 17 novice nurses, 2 supervisors, and 2 experienced nurses who were selected through purposeful sampling from four hospitals dependent on Tehran University of Medical Sciences. Participants' experiences were reflected in three main themes of "functional disability", "communicative problems", and "managerial challenges". Each of these dimensions consisted of several sub-categories. These areas had represented the inability to apply the learned knowledge in practice. The sensitivity of health system, especially, educational mentors and nursing managers to create preparation in novice nurses by providing appropriate orientation programs at the beginning of work and the revision and amendment of nursing curriculum can solve this problem to some extent.

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