Vancouver, Canada

Aquinox Pharmaceuticals

www.aqxpharma.com
Vancouver, Canada

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Patent
Aquinox Pharmaceuticals | Date: 2017-04-19

Compounds of formula (Ia):^(1), R^(2), R^(3), R^(4a), R^(4b), R^(5) and R^(6) are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.


Patent
Aquinox Pharmaceuticals | Date: 2017-01-20

This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.


Patent
Aquinox Pharmaceuticals | Date: 2016-12-06

Compounds of formula (I): where n, R^(1), R^(4a), R^(4b), R^(5), R^(7 )and R^(8 )are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


The present invention is generally directed to novel crystalline forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol and processes for their preparation.


Patent
Aquinox Pharmaceuticals | Date: 2014-01-07

Compounds of formula (I): where n, R^(1), R^(4a), R^(4b), R^(5), R^(7 )and R^(8 )are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


Patent
Aquinox Pharmaceuticals | Date: 2014-01-23

Processes for making and using compounds of formula (I): wherein R^(1), R^(2), R^(3), R^(4a), R^(4b), R^(5 )and R^(6 )are defined herein, as well as other indene derivatives are disclosed herein. These compounds are disclosed as being useful in treating inflammatory conditions or diseases.


Patent
Aquinox Pharmaceuticals | Date: 2014-02-27

Compounds of formula (II): wherein A, R^(1), R^(2), R^(5 )and R^(13 )are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


Patent
Aquinox Pharmaceuticals | Date: 2014-01-07

Compounds of formula (I): where, n, R^(1), R^(4a), R^(4b), R^(5), R^(7 )and R^(8 )are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


Patent
Aquinox Pharmaceuticals | Date: 2014-02-27

Compounds of formula (I): where R^(1), R^(2), R^(3), R^(4a), R^(4b), R^(5), R^(6 )and R^(7 )are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


Patent
Aquinox Pharmaceuticals | Date: 2014-01-23

Processes for making and using compounds of formula (I): wherein R^(1), R^(2), R^(3), R^(4a), R^(4b), R^(5 )and R^(6 )are defined herein, as well as other indene derivatives are disclosed herein. These compounds are disclosed as being useful in treating inflammatory conditions or diseases.

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