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Kansas City, MO, United States

Mercadante S.,La Maddalena Cancer Center | Mercadante S.,University of Palermo | Porzio G.,Aquila
Critical Reviews in Oncology/Hematology | Year: 2012

Malignant bowel obstruction (MBO) is a challenging complication of advanced cancer. Conservative treatment of inoperable MBO in terminal cancer patients has been found to be effective in controlling the distressing symptoms caused by this complication in inoperable cancer patients. Twenty years ago, octreotide was proposed to treat symptoms related to malignant bowel obstruction. Since then several reports have confirmed the efficacy of octreotide in the management of gastrointestinal symptoms of MBO. Fifteen randomized controlled trials or observational reports with a significant number of patients treated with octreotide have been reviewed; 281 patients were surveyed. Authors reported a therapeutic success ranging between 60% and 90%. Despite the limited number of controlled studies, the large experience acquired through 20 years suggests that octreotide is the first-choice antisecretory agent for MBO. As such, octreotide is the only drug approved by the health-care system in Italy for this treatment. © 2012 Elsevier Ireland Ltd.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 1.08M | Year: 2016

The current paradigm in service provisioning to future communication networks lacks thorough end-to-end interpretation from the quality viewpoint, while the end-users/customers profiles and preferences are mostly not taken into account. The subjective perception of a provided service, known as Quality of Experience (QoE), is one of the most important factors for a users decision on retaining the service or giving it up, and the key parameter for enabling advanced customer experience management (CEM). The main objective of CASPER is to combine academic and industrial forces towards leveraging the expected benefits of QoE exploitation in future networks. In particular, CASPER will exploit the most recent approaches in communication networks, such as the Software Defined Networking (SDN) and the Network Functions Virtualisation (NFV), to design and implement a middleware architecture for QoE-driven service provisioning. The architecture will consist of three interlinked modules, one-to-one mapped to the three instrumental functionalities required for the beneficial exploitation of QoE: i) reliable, secure and passive QoE monitoring, ii) efficient, dynamic and objective QoE estimation, and iii) robust and real-time QoE-driven service management. The three modules will be optimised and released as an integrated solution, in order to accelerate the adoption of QoE-driven network service management. The cornerstone of this effort will be a carefully-planned inter-sectorial secondment programme for Experienced Researchers (ERs) and Early Stage Researchers (ESRs). Under this programme, CASPER is expected to foster the exchange of knowledge and strengthen the collaboration among academia and industry through a bidirectional knowledge-sharing approach, where the academic beneficiaries will contribute by conveying their knowledge in QoE analysis and modelling, while industrial beneficiaries will provide their expertise in service development and software implementation.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.23M | Year: 2011

Current 4G vision envisages higher data rates and multi standard radio interfaces to provide all users with a continuous seamless connection. The large number of foreseen devices coupled with the surge in power requirements for future emerging handsets raises significant challenges in terms of: i) reducing the energy consumption; and ii) reducing the amount of electromagnetic radiations. GREENET targets the following main objectives: 1. Recruitment of ESRs with the clear and long-term objective to conduct top-notch research and to pursue research excellence at the national, European, and international levels. 2. Develop training and career plans that are personalized as possible to meet the needs and desires of each ESR. 3. To allow the ESRs to understand and address key research challenges on energy efficient GREENET communications, that form pivotal societal and economic concerns for Europe within the mid-to-long term. 4. Offer to each ESR top-level training and research programs with the twofold objective to reinforce and corroborate their own background, as well as to complement this with active participation in a multi-disciplinary network of research scientists. 5. Complement the typical competences of applied research with aspects related to project management, intellectual property rights, writing of patents, presentation and communication skills, writing of technical papers, exploitation of technical results and creation of start-up companies, etc. 6. Guide and help the ESRs to build the bridge from academia to a remarkable and untactful professional career in either the private or public sectors.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 346.50K | Year: 2016

Endometriosis (the presence of endometrial-like tissue or lesions outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 2.64M | Year: 2014

Smart energy networks (SENs) are electric systems that use two-way networking technologies, cyber-secure communications technologies, and computational intelligence and control in an integrated fashion to efficiently manage energy consumption with the aim of providing a new electricity grid that is clean, safe, secure, reliable, resilient, efficient, and environmentally sustainable. SENs can be well regarded as a system of many systems, whose design challenges, requirements, and expectations can only be achieved through a holistic analysis, design, and optimization of all its components. In SMART-NRG, we will go beyond state-of-the-art approaches for SENs by introducing an innovative and integrated protocol stack, which will be made of three interlinked and optimized sub-systems: i) reliable communications and networking; ii) smart energy management; and iii) security and protection, which are one-to-one connected to the three key functionalities of SENs. The sub-systems will be studied, optimized, and integrated in a very efficient protocol stack, which will be tested via system level simulations and hardware testbeds, and, eventually, will be integrated into commercial devices. According to this view, the project has four main scientific objectives: 1. The proposal of a new protocol stack and network architecture for SENs integrating communications, energy management, and security protocols, along with their analysis, design, and optimization for smart metering applications. 2. The analysis, the design, and the optimization of an efficient and reliable two-way smart meter communication infrastructure by embracing a stochastic network modeling framework. 3. The analysis, the design, and the optimization of advanced smart energy management algorithms for better energy utilization. 4. The analysis, the design, and the optimization of advanced security and privacy mechanisms for large-scale networks with reduced management and control overhead.

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