Lyngby, Denmark
Lyngby, Denmark

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Agency: European Commission | Branch: H2020 | Program: IA | Phase: BIOTEC-4-2014 | Award Amount: 7.68M | Year: 2015

In the vaccine industry, downstream processing is of extreme importance. Prophylactic vaccines aim at protecting healthy people, so any contaminant has to be discarded with the most drastic measures. Such negative approach comes at the expense of the recovery of product : yields are poor, thereby inducing a high product cost. Processes are also complex, since they rely on multiple eliminations rather than on recovery of the unique product of interest. Technically, this is mostly due to the lack of specific capture systems that would allow direct, positive separation of the vaccine from its environment.Vaccines know no borders. For developing countries, the pressure on costs is even more acute, and local production is a way to try to reach the 1$ per dose target. In this context, water sustainability is a major issue, as it is a most sensitive ingredient in bioproduction. DiViNe will tackle theses cost and environmental issues with technological answers. The partners will combine two major Nano/biotechnology innovations to develop an integrated purification platform amenable to the different natures of vaccines : glycoconjugates, protein antigens and enveloped viruses. They will implement Nanofitins (novel affinity capture ligands) and Aquaporin-based membranes (energy-saving nano-biomimetics used in the cleantech industry), for a positive purification approach. High yields are expected (data from antibody purification with Nanofitins), at affordable cost of goods and with a sustainable approach of water recycling. Novartis Vaccines brings to the Consortium a broad range of targets, and identical strategies can be applied for biopharmaceuticals in general. The development custom affinity capture processes as a sustainable platform is therefore economically relevant, in a very large market. Beyond the technical partnership, the project is a first run for the partners to structure the platform as a commercial offer for downstream processing of biologics.


Dublin, Dec. 15, 2016 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Membrane Technology for Liquid and Gas Separations" report to their offering. The combined U.S. market for membranes used in liquid and gas separations should reach $4.6 billion by 2021 from $3.4 billion in 2016 at a compound annual growth rate (CAGR) of 6.2%, from 2016 to 2021. This report is primarily a study of the U.S. market, but due to the international presence of many industry participants, global activities are included where appropriate. Values are given in U.S. dollars, and revenue is counted at the manufacturer level. Forecasts are in constant U.S. dollars and growth rates are compounded. Five-year projections are provided for market activity and value. Industry structure, technological trends, pricing considerations, R&D, government regulations, company profiles and competitive technologies are included in the study. Only industrial-scale membrane products will be evaluated. No consumer products (i.e., point-of-use water systems) are included in the analysis. Key Topics Covered: 1: Introduction - Study Goal And Objectives - Reasons For Doing The Study - Intended Audience - Scope Of Report - Information Sources 2: Executive Summary 3: Industry Overview - History Of The Industry - Membrane Technology - Methods Of Filtration 4: Membrane Technology Types - Reverse Osmosis - Nanofiltration - Ultrafiltration - Microfiltration - Electrochemical Processes - Value Of The U.S. Market For Membrane Products Used In Liquid Separations By Membrane Type - Gas Separation - Pervaporation 5: Applications For Membrane Technology - Potable Water Production - Wastewater Treatment - Process-Water Treatment - Food And Beverage - Pharmaceuticals And Biotechnology - Other Industrial Liquid Separations - Industrial Gas Separations 6: Patent Survey - Patents By Application - Patents By Company 7: Industry Structure - Mergers And Acquisitions - Company Profiles - 3M Purification - Advantec MFS Inc. - Air Liquide - Air Products And Chemicals Inc. - Alfa Laval - Amfor Inc. - Applied Membranes Inc. - Applied Membrane Technology - Aquamarijn Microfiltration BV - Aquaporin A/S - Asahi Kasei - Astom Corp. - Atech Innovations Gmbh - Berghof Filtrations Und Anlagentechnik Gmbh - BWT Group - Cameron International - Cantel Medical - Clean Membranes Inc. - Compact Membrane Systems - Daicen Membrane Systems Ltd. - Donaldson Co. - DOW Chemical Co. - Econity - Eltron Research & Development - Entegris Inc. - Evonik Industries AG - Evoqua Water Technologies - General Electric - Gea Westfalia Separator Group GMBH - Genesis Fueltech Inc. - GKN Sinter Metals Filters GMBH - Graver Technologies - Honeywell International - HY9 Corp. - Hydration Technology Innovations - Hydrogenics Corp. - Hyflux Ltd. - Imbrium Systems Corp. - Imtex Membranes Corp. - INGE GMBH - Innovative Gas Systems (Igs) - ITM Power Plc - ITN Nanovation AG - Jiangsu Jiuwu Hi-Tech Co. Ltd. - Koch Membrane Systems - Kubota Corp. - Lanxess AG - Lg Water Solutions - Mantec Technical Ceramics Ltd. - Markel Corp. - Media And Process Technology - Meissner Filtration Products Inc. - Membrana-Charlotte - Mempore Corp. - Membrane Technology & Research Inc. - Membranes International - Memstar Technology Ltd. - Microdyn-Nadir Gmbh - Milliporesigma - Mitsubishi Rayon Co. Ltd. - Mmf Maxflow Membran Filtration Gmbh - Mtb Technologies - Nanoasis - Natrix Separations - New Logic International - NGK Insulators Ltd. - Nitto Denko Corp. - Novasep Process - Oasys - Pall Corp. - Parker Hannifin Corp. - PCA-Polymerchemie Altmeier Gmbh Und Pccell Gmbh - Pentair Inc. - Permionics - Pervatech BV - Pionetics Corp. - Polyan Gmbh - Polymem S.A. - Porifera Inc. - Porvair Plc - Praxair Inc. - Prime Water Bvba - PWN Technologies - QUA Group - Reb Research And Consulting - Saes Pure Gas - Sartorius - Separation Dynamics Inc. - Simpore - Sinomem Technology. Ltd. - Snowpure Llc - Specialty Silicone Products Inc. - Spectrum Laboratories - Spintek Systems - Suez Environnement - Sulzer Chemtech Ltd. - Sumitomo Electric Industries - Synder Filtration - Synkera Technologies Inc. - T3 Scientific Llc - TAMI Industries - Tianjin Motimo Membrane Technology Ltd. - Tokuyama Corp. - Toray Industries - Toyobo Co. Ltd. - Trisep Corp. - UBE Industries - Ultura GMBH - Veolia Water - Voltea - W.L. Gore & Associates - Xylem - Yuasa Membrane Systems Co. Ltd. For more information about this report visit http://www.researchandmarkets.com/research/s5fpvr/membrane


A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.


Patent
Aquaporin | Date: 2011-09-28

A liquid membrane matrix is disclosed in the form of an aquaporin containing bulk liquid membrane matrix (BLM), wherein said liquid membrane matrix is formed from a solution of an amphiphilic copolymer detergent wherein transmembrane proteins have been functionally incorporated and wherein said matrix further contains a stabilising oil phase. The uses of the membrane matrix include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.


Patent
Aquaporin | Date: 2010-04-28

Membranes and devices incorporating them are useful in water filtration and purification. Disclosed are water membranes comprising aquaporin water transport proteins that have been reconstituted in lipid vesicles and transformed into a supported layer. Also disclosed are water purification devices/systems, including reverse osmosis filtering devices that include the membranes, methods of preparing the membranes and devices, and their use in methods of water purification.


Patent
Aquaporin and Nanyang Technological University | Date: 2012-03-02

Present invention relates to a thin film composite membrane wherein a thin selective layer, having incorporated amphiphilic vesicles, is supported by a microporous substrate. A process of preparing the thin film composite membrane and its use are also disclosed.


The present invention relates to a hollow fiber (HF) module having fibers modified with a thin film composite (TFC) layer comprising aquaporin water channels.


Patent
Aquaporin | Date: 2011-10-04

A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.


Patent
Aquaporin | Date: 2015-08-21

A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.


Patent
Aquaporin | Date: 2014-02-24

The present invention relates to a water extraction system comprising a flow cell comprising a membrane; said membrane comprising an active layer comprising immobilized aquaporin water channels and a support layer, and said membrane having a feed side and a non-feed side; and an aqueous source solution in fluid communication with the feed side of the membrane.

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