Yang Z.,AMRI |
Jin X.,AMRI |
Guaciaro M.,AMRI |
Molino B.F.,AMRI |
And 4 more authors.
A total synthesis of both diastereomers of the originally proposed structure for streptophenazine A (1) has been achieved. However, both synthetic compounds are different from the natural product. Re-examination of NMR data reported for streptophenazine A and a concise total synthesis of both diastereomers of 17 (17a and 17b) led to the structural revision of streptophenazine A to 17b. Asymmetric synthesis of (-)-streptophenazine A was also conducted, and its absolute configuration was determined to be 1′S,2′R. © 2011 American Chemical Society. Source
Zarins-Tutt J.S.,University of St. Andrews |
Barberi T.T.,University of St. Andrews |
Gao H.,University of St. Andrews |
Mearns-Spragg A.,Aquapharm Biodiscovery Ltd |
And 3 more authors.
Natural Product Reports
Covering: up to 2015 Over the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry. With the increasing number of sequenced microbial genomes revealing a plethora of novel biosynthetic genes, natural product drug discovery is entering an exciting second golden age. Here, we provide a concise overview as an introductory guide to the main methods employed to unlock or up-regulate these so called 'cryptic', 'silent' and 'orphan' gene clusters, and increase the production of the encoded natural product. With a predominant focus on bacterial natural products we will discuss the importance of the bioinformatics approach for genome mining, the use of first different and simple culturing techniques and then the application of genetic engineering to unlock the microbial treasure trove. © The Royal Society of Chemistry 2016. Source
Lallemand U.K. Ltd and Aquapharm Bio Discovery Ltd | Date: 2011-10-18
Chemicals used in industry; biologically derived compounds used in industry and science; chemical compounds and additives for use with fungicides; chemical compounds and additives for use with insecticides; bacterial preparations other than for medical and veterinary use; bacteriological preparations other than for medical and veterinary use; biological preparations other than for medical or veterinary purposes; enzymes other than for medical and veterinary use for scientific and research use; enzymes for use in foodstuffs; enzymes for use in colourings; bacteria for use in industry and science; fungi for use in industry and science; marine bacteria and fungi for use in industry and science; anti-fungal preparations for use in industry and science; chemical preparations and chemical reagents for scientific and industrial use, other than for medical or veterinary use; chemicals for use in agriculture and horticulture; functional molecules for use in science and industry; carotenoids for use in science and industry; biocatalysts; preparation and cultures of microorganisms for use in science and industry, other than for medical and veterinary use; chemical preparations for the manufacture of pigments; preservatives for pharmaceutical preparations; non-antimicrobial preservatives, other than for foodstuffs, namely, for cosmetics and personal care products; water purifying chemicals; none of the aforesaid relating to water treatment using salt or water processing using salt. Pharmaceutical and veterinary preparations for treatment of infectious disease, skin disorders and auto-immune disorders and for treatment of tissue and organ degeneration; anti-inflammatories; dietetic substances, namely, beverages and foods adapted for medical use; all purpose disinfectants; fungicides, herbicides; antibiotics and antifungal preparations; carotenoids for medical use; biocides; biological preparations, namely, fungicides, antibiotics and anti-inflammatories for medical purposes; biological preparations, namely, fungicides, antibiotics and anti-inflammatories for veterinary purposes; chemical preparations and reagents for medical or veterinary purposes; enzymes and enzyme preparations for medical and/or veterinary purposes; functional molecules for medical and/or veterinary purposes; synthetic peptides and peptones for medical, pharmaceutical and/or veterinary purposes.
Aquapharm Bio Discovery Ltd | Date: 2012-02-15
Chemical preparations and chemical products for use in industry; chemical preparations and chemical products for use in toiletries, cosmetics and skin care preparations; raw materials and ingredients for use in toiletries, cosmetics and skin care preparations; chemical preparations, products and substances for use as ingredients for foodstuffs; chemical preparations, products and substances for use as ingredients for beverages; chemical preparations, products and substances for use as ingredients or additives for nutraceuticals. Non-medicated toilet preparations; cosmetics; skin care preparations; toiletries; bath and shower preparations; hair care preparations; shampoos; perfumery; essential oils; soaps; deodorants for personal use; ingredients for use in toiletries, cosmetics, skin care preparations, bath and shower preparations, hair care preparations and shampoos; products containing active ingredients for toilet and cosmetic purposes. Pharmaceutical preparations and substances; nutraceutical preparations and substances; dietetic substances adapted for medical use; preparations containing or based on vitamins, trace elements and/or minerals for dietetic purposes or as nutritional supplements; food supplements for medical purposes; nutritional supplements for medical purposes; health food supplements; mineral food supplements; vitamins and minerals; vitamin preparations in the nature of food supplements; mineral preparations in the nature of food supplements; vitamin drinks adapted for medical purposes; mineral drinks adapted for medical purposes; pharmaceutical preparations to be used as additives to foodstuffs; pharmaceutical preparations to be used as additives to beverages; medicated lotions; medicated skin care preparations; medicated bath and shower preparations; medicated preparations for the care of the scalp.
Novak H.R.,University of Exeter |
Sayer C.,University of Exeter |
Isupov M.N.,University of Exeter |
Gotz D.,Aquapharm Biodiscovery Ltd |
And 2 more authors.
A putative haloalkane dehalogenase has been identified in a marine Rhodobacteraceae and subsequently cloned and over-expressed in Escherichia coli. The enzyme has highest activity towards the substrates 1,6-dichlorohexane, 1-bromooctane, 1,3-dibromopropane and 1-bromohexane. The crystal structures of the enzyme in the native and product bound forms reveal a large hydrophobic active site cavity. A deeper substrate binding pocket defines the enzyme preference towards substrates with longer carbon chains. Arg136 at the bottom of the substrate pocket is positioned to bind the distal halogen group of extended di-halogenated substrates. © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Source