Aptus BioSciences Private Ltd

Lal Bahadur Nagar, India

Aptus BioSciences Private Ltd

Lal Bahadur Nagar, India
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Ramesha P.,Sri Venkateswara University | Srinivasulu D.,Sri Venkateswara University | Subba Rao D.,Sri Venkateswara University | Hema kumar K.,Aptus Biosciences Private Ltd | And 2 more authors.
Der Pharmacia Lettre | Year: 2012

A simple, economical and practical synthetic procedure has developed for synthesizing various 2-substituted methyl-3-substituted phenylquinazolin-4(3H)-one derivatives 4(a,b)-8(a,b) in good yields from anthranilic acid (1). The developed procedure is very effective in respect of handling, yields and economic point of view. The structural characterization of synthesized products was elucidated by FT-IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. Anti-inflammatory activity of the synthesized quinazolin-4(3H)-one derivatives was screened after the acute toxicology studies examined on the title compounds. The results revealed that 5a, 8a compounds exhibited potential activity and remaining compounds were shown moderate anti-inflammatory activity on tested animals.


Chandrasekhar P.,Aptus Biosciences Private Ltd | Lakshmi T.,Aptus Biosciences Private Ltd | Suresh S.,Aptus Biosciences Private Ltd
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: To perform Bacterial Reverse Mutation Test[1] with jatamansi (Nardostachysjatamansi plant rhizome powder) using Salmonella typhimurium tester strains TA 1535, TA 1537, TA 98, TA 100, and TA 102 both in the presence and absence of metabolic activation system for finding the mutagenicity as per the OECD guideline No. 471[2]. Method: Plate Incorporation Method. Results: Substantial increase in revertant colony number was not observed in all the Salmonella typhimurium tester strains both in the presence and absence of metabolic activation system up to the dose 5.0 mg/plate, where negative control results are with in the range and positive controls shown significant increase in the revertant colony number. Conclusion: Jatamansi did not induced any gene mutation in the genome of Salmonella typhimurium tester strains, hence Jatamansi is non mutagenic and non cytotoxic in this test.


Deshmukh G.R.,Aptus Biosciences Private Ltd | Kumar K.H.,Aptus Biosciences Private Ltd | Reddy P.V.S.,Aptus Biosciences Private Ltd | Rao B.S.,Aptus Biosciences Private Ltd
Toxicology in Vitro | Year: 2012

The present article is an attempt to validate the in vitro skin corrosion human skin model test as per the OECD test guidelines 431 as an alternative method for in vivo skin corrosion/irritation test. All over India, in vivo skin corrosion/irritation test is commonly used, rather than in vitro skin corrosion models. Hence, the present study was under taken with EpiSkinTM, SNC, Lyon, France to validate this in vitro model. Various corrosive and non corrosive chemicals with their known skin corrosive property were used to validate the study as specified under the guideline (OECD 431). The results obtained in this study were in accordance with the corrosive properties of the respective chemicals. © 2012 Elsevier Ltd.


Rao V.K.,Sri Venkateswara University | Reddy S.S.,Sri Venkateswara University | Babu K.R.,Sri Venkateswara University | Kumar K.H.,Aptus Biosciences Private Ltd | And 2 more authors.
Journal of the Korean Chemical Society | Year: 2011

Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.


Suresh Reddy P.V.,Dravidian University | Suresh Reddy P.V.,Aptus Biosciences Private Ltd | Hema Kumar K.,Dravidian University | Hema Kumar K.,Aptus Biosciences Private Ltd | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012

Arsenic is a well-known toxic and carcinogenic metalloid distributed all over the world causing serious health threats via drinking water. The present study was performed to evaluate the mutagenic potential of Sodium(meta)arsenite in the Bacterial Reverse Mutation Assay using five tester strains of Salmonella typhimurium TA1537, TA1535, TA98, TA100 and TA102. Sodium(meta)arsenite was not detected as mutagen in any of the tester strain, as it may act through other, non-genotoxic mechanism or mechanisms absent in bacterial cells.


Katla V.R.,Sri Venkateswara University | Syed R.,Sri Venkateswara University | Kuruva C.S.,Sri Venkateswara University | Kuntrapakam H.K.,Aptus BioSciences Private Ltd | Chamarthi N.R.,Sri Venkateswara University
Chemical and Pharmaceutical Bulletin | Year: 2013

A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a-l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity. © 2013 The Pharmaceutical Society of Japan.


PubMed | Aptus Biosciences Private Ltd
Type: Journal Article | Journal: Toxicology in vitro : an international journal published in association with BIBRA | Year: 2012

The present article is an attempt to validate the in vitro skin corrosion human skin model test as per the OECD test guidelines 431 as an alternative method for in vivo skin corrosion/irritation test. All over India, in vivo skin corrosion/irritation test is commonly used, rather than in vitro skin corrosion models. Hence, the present study was under taken with EpiSkinTM, SNC, Lyon, France to validate this in vitro model. Various corrosive and non corrosive chemicals with their known skin corrosive property were used to validate the study as specified under the guideline (OECD 431). The results obtained in this study were in accordance with the corrosive properties of the respective chemicals.


PubMed | Aptus Biosciences Private Ltd
Type: | Journal: ISRN toxicology | Year: 2013

The present paper is an attempt to investigate the eye irritation potential of aqueous leaf extract of Achyranthes aspera by in vitro, Hens Egg Chorioallantoic Membrane Test (HET-CAM) and in vivo acute eye irritation test in rabbits. The irritation score (IS) obtained after treatment of the extract on HET-CAM is 0.07 and that of in rabbits is 0.55, Which does not comes under either category 1 or 2 as per the harmonized integrated classification system. The aqueous extract of Achyranthes aspera showed no eye irritation properties both in vitro and in vivo methods when compared with negative control whereas positive controls showed eye irritation potential.

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