Rao V.K.,Sri Venkateswara University |
Reddy S.S.,Sri Venkateswara University |
Babu K.R.,Sri Venkateswara University |
Kumar K.H.,Aptus Biosciences Private Ltd |
And 2 more authors.
Journal of the Korean Chemical Society | Year: 2011
Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.
Suresh Reddy P.V.,Dravidian University |
Suresh Reddy P.V.,Aptus Biosciences Private Ltd |
Hema Kumar K.,Dravidian University |
Hema Kumar K.,Aptus Biosciences Private Ltd |
And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012
Arsenic is a well-known toxic and carcinogenic metalloid distributed all over the world causing serious health threats via drinking water. The present study was performed to evaluate the mutagenic potential of Sodium(meta)arsenite in the Bacterial Reverse Mutation Assay using five tester strains of Salmonella typhimurium TA1537, TA1535, TA98, TA100 and TA102. Sodium(meta)arsenite was not detected as mutagen in any of the tester strain, as it may act through other, non-genotoxic mechanism or mechanisms absent in bacterial cells.
Katla V.R.,Sri Venkateswara University |
Syed R.,Sri Venkateswara University |
Kuruva C.S.,Sri Venkateswara University |
Kuntrapakam H.K.,Aptus BioSciences Private Ltd |
Chamarthi N.R.,Sri Venkateswara University
Chemical and Pharmaceutical Bulletin | Year: 2013
A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a-l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity. © 2013 The Pharmaceutical Society of Japan.
PubMed | Aptus Biosciences Private Ltd
Type: Journal Article | Journal: Toxicology in vitro : an international journal published in association with BIBRA | Year: 2012
The present article is an attempt to validate the in vitro skin corrosion human skin model test as per the OECD test guidelines 431 as an alternative method for in vivo skin corrosion/irritation test. All over India, in vivo skin corrosion/irritation test is commonly used, rather than in vitro skin corrosion models. Hence, the present study was under taken with EpiSkinTM, SNC, Lyon, France to validate this in vitro model. Various corrosive and non corrosive chemicals with their known skin corrosive property were used to validate the study as specified under the guideline (OECD 431). The results obtained in this study were in accordance with the corrosive properties of the respective chemicals.
PubMed | Aptus Biosciences Private Ltd
Type: | Journal: ISRN toxicology | Year: 2013
The present paper is an attempt to investigate the eye irritation potential of aqueous leaf extract of Achyranthes aspera by in vitro, Hens Egg Chorioallantoic Membrane Test (HET-CAM) and in vivo acute eye irritation test in rabbits. The irritation score (IS) obtained after treatment of the extract on HET-CAM is 0.07 and that of in rabbits is 0.55, Which does not comes under either category 1 or 2 as per the harmonized integrated classification system. The aqueous extract of Achyranthes aspera showed no eye irritation properties both in vitro and in vivo methods when compared with negative control whereas positive controls showed eye irritation potential.