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Rao V.K.,Sri Venkateswara University | Reddy S.S.,Sri Venkateswara University | Babu K.R.,Sri Venkateswara University | Kumar K.H.,Aptus BioSciences Private Ltd | And 2 more authors.
Journal of the Korean Chemical Society | Year: 2011

Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.

Katla V.R.,Sri Venkateswara University | Syed R.,Sri Venkateswara University | Kuruva C.S.,Sri Venkateswara University | Kuntrapakam H.K.,Aptus BioSciences Private Ltd | Chamarthi N.R.,Sri Venkateswara University
Chemical and Pharmaceutical Bulletin | Year: 2013

A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a-l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity. © 2013 The Pharmaceutical Society of Japan.

Suresh Reddy P.V.,Dravidian University | Suresh Reddy P.V.,Aptus BioSciences Private Ltd | Hema Kumar K.,Dravidian University | Hema Kumar K.,Aptus BioSciences Private Ltd | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012

Arsenic is a well-known toxic and carcinogenic metalloid distributed all over the world causing serious health threats via drinking water. The present study was performed to evaluate the mutagenic potential of Sodium(meta)arsenite in the Bacterial Reverse Mutation Assay using five tester strains of Salmonella typhimurium TA1537, TA1535, TA98, TA100 and TA102. Sodium(meta)arsenite was not detected as mutagen in any of the tester strain, as it may act through other, non-genotoxic mechanism or mechanisms absent in bacterial cells.

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