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Nordborg, Denmark

Zhou X.,CAS Shanghai Institute of Organic Chemistry | Zhou X.,Applied Biomimetic | Constant J.-F.,CNRS Molecular Chemistry Department
Bioorganic and Medicinal Chemistry | Year: 2010

Oligonucleotide-selenium conjugate was designed and synthesized and its sequence-specific cross-linking ability was investigated. The selenide derivatives can generate covalent interstrand cross-linking with its complementary strand through the formation of o-QM intermediate induced by periodate oxidation. A cross-linking reaction yield of up to 50% was obtained. Hydroxyl radical footprinting experiment revealed that the quinone appendage specifically alkylated the cytosine base extending the duplex formed between the conjugate and the target strand. © 2009 Elsevier Ltd. All rights reserved. Source


Applied Biomimetic | Entity website


Applied Biomimetic | Entity website


Applied Biomimetic | Entity website

From Pure Science - To Commercial Applications Based on several years of scientific research, Danfoss, theDanish international industrial group, initiated development of commercial applications for aquaporin in 2006. Initial progress included development of in-house aquaporin production and experimental solutions for embedding aquaporins in polymer ...


Madsen H.T.,University of Aalborg | Nissen S.S.,Applied Biomimetic | Sogaard E.G.,University of Aalborg
Chemical Engineering Science | Year: 2016

Pressure retarded osmosis (PRO) has traditionally been focused on the mixing of seawater and river water, but in pilot scale tests, this mixing scheme has been found to be economically unattractive due to power densities that are too low. One way of obtaining higher power densities may be through use of hypersaline draw solutions. In this work, the theoretical framework for calculation of the free energy of mixing, the maximum extractable work in batch and co-current PRO systems, and the potential power densities of hypersaline solutions is presented. Calculations show that very high values in all categories are realizable. By diluting 26wt% (saturated NaCl) to seawater concentration, 15.7kWh/m3 draw is released and a maximum power density of 143W/m2 membrane can be obtained with a commercially available FO membrane. In cases where the hypersaline solution is the limiting solution, large losses of energy can be expected if the process is carried out as a constant pressure single stage operation. To minimize losses, a serial setup can be applied. Although the practical challenges for hypersaline PRO may be greater than for seawater based PRO, the high potential gains may make hypersaline PRO a more promising way of making the PRO concept realizable. © 2015 Elsevier Ltd. Source

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