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Antoci V.,Al. I. Cuza University | Mantu D.,Al. I. Cuza University | Cozma D.G.,Al. I. Cuza University | Usru C.,Apollonia University of Iasi | Mangalagiu I.I.,Al. I. Cuza University
Medical Hypotheses | Year: 2014

Antitumour chemotherapy is nowadays a very active field of research, DNA targeting drugs being the most widely used group in therapy. The design, synthesis and anticancer activity of a new class of anticancer derivatives with pyrrolo-1,2-diazine and benzoquinone skeleton is presented. The synthesis is direct and efficient, involving an alkylation followed by a [3+2] dipolar cycloaddition. The penta- and tetra-cyclic pyrrolo-1,2-diazine were evaluated for their in vitro anticancer activity against an NCI 60 human tumour cell line panel. The pentacyclic-1,2-diazine exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM and Breast Cancer MCF7. We hypothesize that these molecules will exert their anticancer activity through multiple mechanisms of action: intercalating the DNA, inhibiting the topoisomerase enzymes and, destroying the DNA strands via electron transfer mechanism. However, the intercalation with the DNA seems to prevail in competition with the others mechanisms. © 2013 Elsevier Ltd. Source


Hanu Cimpoesu R.,Technical University Gheorghe Asachi | Mareci D.,Technical University Gheorghe Asachi | Aelenei N.,Technical University Gheorghe Asachi | Bolat G.,Technical University Gheorghe Asachi | And 3 more authors.
Journal of Optoelectronics and Advanced Materials | Year: 2011

In this work are presented preliminary tests of corrosion characteristics of NiTi alloy coated with three different polymers coatings deposited by pulser laser deposition. The potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) have been employed to study the corrosion performance of the NiTi coated samples in AFNOR artificial saliva. All the polymers coating showed a very corrosion resistance for a short-term immersion. The EIS results exhibited high impedance values (order of 106 ω cm2) obtained from medium to low frequencies which are indicative of the presenting of a highly stable film on all coated NiTi alloys in the artificial saliva. The EIS spectra are fitted using an equivalent circuit. For NiTi coated samples maintained short time in artificial saliva, a two-layer model of an unsealed porous film is suitable. Source


Amarioarei G.,Technical University Gheorghe Asachi | Lungu M.,Apollonia University of Iasi | Ciovica S.,Technical University Gheorghe Asachi
Cellulose Chemistry and Technology | Year: 2012

The polysaccharide components of cherry tree exudate gum (Prunus cerasus, Prunus avium) belong to the arabinogalactan group. There are structural variations in the proportion of monosaccharides, molar ratio and glycosidic linkages, which determine the properties and use of exudate gums. In this paper, Size Exclusion Chromatography (SEC/GPC) is applied for determining polydispersity and molecular mass (Mw) of the cherry tree exudate gum of P. avium, P. cerasus and egg plum (P. domestica). The intrinsic viscosity values of cherry tree EAL gum solutions were also obtained, confirming the existence of a compact internally crosslinked structure of the exudate gum polysaccharide. The results of Brookfield viscosity characterization outline the essential characteristics of the cherry gum exudates. Source


Mantu D.,Al. I. Cuza University | Maftei D.,Al. I. Cuza University | Iurea D.,Romanian Institute of Biological Research | Ursu C.,Apollonia University of Iasi | Bejan V.,Al. I. Cuza University
Medicinal Chemistry Research | Year: 2014

The synthesis, structure, and in vitro anticancer activity of a new class of anticancer derivatives with dihydrobenzo[5,6]isoindolo[1,2-A]phthalazine and dihydrobenzo[f]pyridazino[6,1-A]isoindole skeletons are presented. The preparation is straight and efficient, involving two steps only: a N-Alkylation of the pyridazine or phthalazine heterocycle, followed by a [3 + 2] dipolar cycloaddition of 1,2-diazinium ylides to the corresponding dipolarophiles. The synthesis was performed under microwave and ultrasound (US) irradiation as well as under conventional thermal heating. The most effective conditions in term of yields and time were found to be US irradiation. The penta- and tetra-cyclic 1,2-diazines were evaluated for their in vitro anticancer activity. The pentacyclic 1,2-diazine derivatives exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM, and Breast Cancer MCF7. A feasible explanation for anticancer efficiency of the pentacyclic 1,2-diazines have been furnished, being correlated with the mechanisms of action. Graphical Abstract: The synthesis (conventional thermal heating, microwave and ultrasound irradiation), structure, and in vitro anticancer activity of a new class of anticancer molecules with polycyclic 1,2-diazines skeleton is presented.[Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York. Source


Cadinoiu A.N.,Apollonia University of Iasi | Cadinoiu A.N.,Technical University Gheorghe Asachi | Peptu C.A.,Technical University Gheorghe Asachi | Fache B.,University of Toulon | And 2 more authors.
Journal of Microencapsulation | Year: 2015

Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4 m, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6 h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases. © 2015 Informa UK Ltd. All rights reserved. Source

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