Apollonia University of Iasi

Iaşi, Romania

Apollonia University of Iasi

Iaşi, Romania
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Duceac L.D.,Apollonia University of Iasi | Straticiuc S.,Apollonia University of Iasi | Hanganu E.,Grigore T. Popa University of Medicine and Pharmacy | Stafie L.,Apollonia University of Iasi | And 2 more authors.
IOP Conference Series: Materials Science and Engineering | Year: 2017

Nowadays bone implant removal is caused by infection that occurs around it possibly acquired after surgery or during hospitalization. The purpose of this study was to reveal some metal oxides applied as coatings on bone implant thus limiting the usual antibiotics-resistant bacteria colonization. Therefore ZnO, TiO2 and CuO were synthesized and structurally and morphologically analized in order to use them as an alternative antimicrobial agents deposited on bone implant. XRD, SEM, and FTIR characterization techniques were used to identify structure and texture of these nanoscaled metal oxides. These metal oxides nanocoatings on implant surface play a big role in preventing bacterial infection and reducing surgical complications. © Published under licence by IOP Publishing Ltd.


Amarioarei G.,Technical University Gheorghe Asachi | Lungu M.,Apollonia University of Iasi | Ciovica S.,Technical University Gheorghe Asachi
Cellulose Chemistry and Technology | Year: 2012

The polysaccharide components of cherry tree exudate gum (Prunus cerasus, Prunus avium) belong to the arabinogalactan group. There are structural variations in the proportion of monosaccharides, molar ratio and glycosidic linkages, which determine the properties and use of exudate gums. In this paper, Size Exclusion Chromatography (SEC/GPC) is applied for determining polydispersity and molecular mass (Mw) of the cherry tree exudate gum of P. avium, P. cerasus and egg plum (P. domestica). The intrinsic viscosity values of cherry tree EAL gum solutions were also obtained, confirming the existence of a compact internally crosslinked structure of the exudate gum polysaccharide. The results of Brookfield viscosity characterization outline the essential characteristics of the cherry gum exudates.


Mantu D.,Al. I. Cuza University | Maftei D.,Al. I. Cuza University | Iurea D.,Romanian Institute of Biological Research | Ursu C.,Apollonia University of Iasi | Bejan V.,Al. I. Cuza University
Medicinal Chemistry Research | Year: 2014

The synthesis, structure, and in vitro anticancer activity of a new class of anticancer derivatives with dihydrobenzo[5,6]isoindolo[1,2-A]phthalazine and dihydrobenzo[f]pyridazino[6,1-A]isoindole skeletons are presented. The preparation is straight and efficient, involving two steps only: a N-Alkylation of the pyridazine or phthalazine heterocycle, followed by a [3 + 2] dipolar cycloaddition of 1,2-diazinium ylides to the corresponding dipolarophiles. The synthesis was performed under microwave and ultrasound (US) irradiation as well as under conventional thermal heating. The most effective conditions in term of yields and time were found to be US irradiation. The penta- and tetra-cyclic 1,2-diazines were evaluated for their in vitro anticancer activity. The pentacyclic 1,2-diazine derivatives exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM, and Breast Cancer MCF7. A feasible explanation for anticancer efficiency of the pentacyclic 1,2-diazines have been furnished, being correlated with the mechanisms of action. Graphical Abstract: The synthesis (conventional thermal heating, microwave and ultrasound irradiation), structure, and in vitro anticancer activity of a new class of anticancer molecules with polycyclic 1,2-diazines skeleton is presented.[Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York.


Duceac L.D.,Apollonia University of Iasi | Velenciuc N.,Oncology Regional Institute of Iasi | Dobre E.C.,Apollonia University of Iasi
IOP Conference Series: Materials Science and Engineering | Year: 2016

In recent years applications of nanotechnology integrated into nanomedicine and bio-nanotechnology have attracted the attention of many researchers from different fields. Processes from chemical engineering especially nanostructured materials play an important role in medical and pharmaceutical development. Fundamental researches focused on finding simple, easily accomplished synthesis methods, morphological aspects and physico-chemical advanced characterization of nanomaterials. More over, by controlling synthesis conditions textural characteristics and physicochemical properties such as particle size, shape, surface, porosity, aggregation degree and composition can be tailored. Low cytotoxicity and antimicrobial effects of these nanostructured materials makes them be applied in medicine field. The major advantage of metal based nanoparticles is the use either for their antimicrobial properties or as drug-carriers having the potential to be active at low concentrations against infectious agents.


Sachelarie L.,Apollonia University of Iasi | Vasiliu M.P.,Apollonia University of Iasi | Farcas D.M.,University of Oradea | Daraba O.M.,Apollonia University of Iasi | Romila L.,Apollonia University of Iasi
Key Engineering Materials | Year: 2016

Interaction mechanisms and biological effects that different types of radiation could exert upon humans have been studied by many authors. Different studies investigated the reactions of various types of electrical equipment, power lines, mobile phones and other upon humans, their influence on the brain functions, public health or if magnetic fields (MFs) can be used for pain relief. Some authors found out that electromagnetic fields (EMFs) might be a factor which determined a number of chronic illnesses (cancer, heart diseases and sleep disorders) even to low intensity. But on the other side, because the EMFs are part of nature, being radiated by human body and its organs, the quality and intensity of the energy can either support or destroy health. Magnetic fields and electromagnetic fields are useful modalities to treat various pathologies and diseases. A number of clinical studies, in vivo animal experiments and in vitro cellular and membrane researches, suggested that EMFs and MFs stimulation reduce pain and accelerate the healing process. However, EMFs are still not widely used in clinical medicine. It is accepted that pain control occurs via a series of integrated stages, each with particular objectives essential to the tissue/system repairing processes. Electric and magnetic stimulation have been proven to provide beneficial and reproducible healing effects even when other methods have failed. As for the MFs, this is an excellent possibility as a non - invasive method to control and treat pain. Magnetic stimulation of a patient is different from drug treatment. As technology proliferates and people use more and more electronic devices, some researchers suspect EMFs contribute to a subtle assault upon people's immune system and health. This paper aims to review the way that electromagnetic fields and other types of radiations interact at molecular level with human organism. © 2016 Trans Tech Publications.


Sachelarie L.,Apollonia University of Iasi | Vasiliu M.P.,Apollonia University of Iasi | Ciobanu C.,Apollonia University of Iasi
Applied Surface Science | Year: 2015

This study's purpose is pointing out the phenomenon that occurs at time of interaction between the tissue with implant. The materials used are Ti and its alloys. The oral tissue must be compatible with the materials used in surgical implant to human body. The bio-materials surface behavior is influenced by physical characteristics. The methods we use show a number of bio-compatibility aspects. The success of an implant in a hard tissue depends not only on the initial attachment and the osteogenic cells consecutive proliferation, but also on their capacity to create a new bone. © 2015 Elsevier B.V. All rights reserved.


Antoci V.,Al. I. Cuza University | Mantu D.,Al. I. Cuza University | Cozma D.G.,Al. I. Cuza University | Usru C.,Apollonia University of Iasi | Mangalagiu I.I.,Al. I. Cuza University
Medical Hypotheses | Year: 2014

Antitumour chemotherapy is nowadays a very active field of research, DNA targeting drugs being the most widely used group in therapy. The design, synthesis and anticancer activity of a new class of anticancer derivatives with pyrrolo-1,2-diazine and benzoquinone skeleton is presented. The synthesis is direct and efficient, involving an alkylation followed by a [3+2] dipolar cycloaddition. The penta- and tetra-cyclic pyrrolo-1,2-diazine were evaluated for their in vitro anticancer activity against an NCI 60 human tumour cell line panel. The pentacyclic-1,2-diazine exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM and Breast Cancer MCF7. We hypothesize that these molecules will exert their anticancer activity through multiple mechanisms of action: intercalating the DNA, inhibiting the topoisomerase enzymes and, destroying the DNA strands via electron transfer mechanism. However, the intercalation with the DNA seems to prevail in competition with the others mechanisms. © 2013 Elsevier Ltd.


Vasiliu M.P.,Apollonia University of Iasi | Sachelarie L.,Apollonia University of Iasi | Tomit D.,Apollonia University of Iasi | Folescu E.,Apollonia University of Iasi | Stadoleanu C.,Apollonia University of Iasi
Key Engineering Materials | Year: 2016

A bio material is a inert and non-viable material with a natural or synthetic origin that comes in to contact with tissues, blood or biological fluids, being used in prosthetic, therapeutic and storage applications, without affecting in any way living organism or their components. Biological systems may produce the deterioration of materials, process known as bio-degradation. In case of oral environment this also includes the dissolution in Sali va, chemical and physical degradation, abrasion and erosion caused by the diet components, mastication process and bacteria actions. Most of the materials used in dental therapy may be toxic or may produce allergies until they bind. We evaluated during our experiment the biological consequences (biocompatibility) that subcutaneous implanting of small acrylic dental fragments have upon tissues in case of white lab mice, keeping an eye on the local tissues reactions. The evaluation of dental materials is made by testing the bio-compatibility. Biologically tests are performed in vivo and in vitro strictly in the lab and on animals. For our experiment we used 20 white mice Wistar line, 8-9 weeks old males, 40 grams, divided in 3 groups; all of them received an acrylic implant. The experiment was centered on the observation of some physiological or pathological effects, local or systemic, that implants may have produced effects that show a toxic answer or the rejection of the material. All experiments was performed in compliance with (European Communities Council Directive 1986 (86/609/EEC) and Ordinance No. 37 of Romanian Government from 2nd February 2002. Materials biocompatibility was highlighted by anatomic-pathological exams during which we noticed all the modifications at dermis level during the entire period. We observed the phenomenon that occurred around the implants at different time periods, than we collected samples. The data obtained at the end of our experiment allow us to sustain that acrylic materials used in dental implants have all the properties required to be considered as biocompatible. © 2016 Trans Tech Publications.


PubMed | Apollonia University of Iasi
Type: Journal Article | Journal: Journal of microencapsulation | Year: 2015

Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4m, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases.


PubMed | Al. I. Cuza University and Apollonia University of Iasi
Type: Journal Article | Journal: Medical hypotheses | Year: 2013

Antitumour chemotherapy is nowadays a very active field of research, DNA targeting drugs being the most widely used group in therapy. The design, synthesis and anticancer activity of a new class of anticancer derivatives with pyrrolo-1,2-diazine and benzoquinone skeleton is presented. The synthesis is direct and efficient, involving an alkylation followed by a [3+2] dipolar cycloaddition. The penta- and tetra-cyclic pyrrolo-1,2-diazine were evaluated for their in vitro anticancer activity against an NCI 60 human tumour cell line panel. The pentacyclic-1,2-diazine exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM and Breast Cancer MCF7. We hypothesize that these molecules will exert their anticancer activity through multiple mechanisms of action: intercalating the DNA, inhibiting the topoisomerase enzymes and, destroying the DNA strands via electron transfer mechanism. However, the intercalation with the DNA seems to prevail in competition with the others mechanisms.

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