Apollo Speciality Cancer Hospitals

Chennai, India

Apollo Speciality Cancer Hospitals

Chennai, India
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Potharaju M.,Apollo Speciality Cancer Hospitals | John R.,Apollo Speciality Cancer Hospitals | Venkataraman M.,Apollo Speciality Cancer Hospitals | Gopalakrishna K.,Apollo Speciality Cancer Hospitals | Subramanian B.,Apollo Speciality Cancer Hospitals
Spine Journal | Year: 2014

METHODS: Three symptomatic patients with intramedullary spinal cord AVMs were treated with SRS using the cyberknife system from January 2010 to May 2011. All the three patients presented with acute neurologic symptoms. Two patients were treated previously with embolization. As per protocol, patients underwent a plain computed tomography (CT), CT angiography, high-resolution MRI, and conventional spinal angiography for radiotherapy planning. The mean target volume was 4.05 cc. The prescribed dose was 21 Gy in three fractions on consecutive days. No special immobilization was done during treatment. Continuous image guidance of the treated area was done using the specialized spine tracking software. Follow-up was done by yearly clinical examination and high-resolution spine MRI after SRS.RESULTS: Mean follow-up was 36 months. Follow-up MRI revealed absence of flow voids, suggesting complete obliteration of the AVM in two patients, with significant improvement in neurologic and functional symptoms. The third patient did not show any clinical improvement or deterioration. There was no incidence of hemorrhage after SRS in any patient and the treatment was well tolerated without any significant complications.CONCLUSIONS: Stereotactic radiosurgery for intramedullary spinal AVMs appears to be well tolerated and effective in selected cases.BACKGROUND CONTEXT: Intramedullary spinal cord arteriovenous malformations (AVMs) are rare and have an unfavorable prognosis. We report our experience of treating three symptomatic patients with stereotactic radiosurgery (SRS). The standard treatment for these lesions are embolization or microsurgical resection. There are only a few reports of efficacy of radiosurgery in these cases.PURPOSE: To study the efficacy of radiosurgery in intramedullary spinal cord AVM patients, who failed or refused conventional treatment. Study setting This study reports the results of SRS in 3 cases of intramedullary spinal cord AVMs.PATIENT SAMPLE: Three symptomatic patients diagnosed with intramedullary spinal cord AVMs. Two patients underwent embolization previously and one was newly diagnosed.OUTCOME MEASURES: The AVM obliteration was assessed by yearly high-resolution magnetic resonance imaging (MRI). Clinical examination was carried out every 6 months. © 2014 Elsevier Inc. All rights reserved.


PubMed | Apollo Speciality Cancer Hospitals
Type: Journal Article | Journal: The spine journal : official journal of the North American Spine Society | Year: 2014

Intramedullary spinal cord arteriovenous malformations (AVMs) are rare and have an unfavorable prognosis. We report our experience of treating three symptomatic patients with stereotactic radiosurgery (SRS). The standard treatment for these lesions are embolization or microsurgical resection. There are only a few reports of efficacy of radiosurgery in these cases.To study the efficacy of radiosurgery in intramedullary spinal cord AVM patients, who failed or refused conventional treatment.This study reports the results of SRS in 3 cases of intramedullary spinal cord AVMs.Three symptomatic patients diagnosed with intramedullary spinal cord AVMs. Two patients underwent embolization previously and one was newly diagnosed.The AVM obliteration was assessed by yearly high-resolution magnetic resonance imaging (MRI). Clinical examination was carried out every 6 months.Three symptomatic patients with intramedullary spinal cord AVMs were treated with SRS using the cyberknife system from January 2010 to May 2011. All the three patients presented with acute neurologic symptoms. Two patients were treated previously with embolization. As per protocol, patients underwent a plain computed tomography (CT), CT angiography, high-resolution MRI, and conventional spinal angiography for radiotherapy planning. The mean target volume was 4.05 cc. The prescribed dose was 21 Gy in three fractions on consecutive days. No special immobilization was done during treatment. Continuous image guidance of the treated area was done using the specialized spine tracking software. Follow-up was done by yearly clinical examination and high-resolution spine MRI after SRS.Mean follow-up was 36 months. Follow-up MRI revealed absence of flow voids, suggesting complete obliteration of the AVM in two patients, with significant improvement in neurologic and functional symptoms. The third patient did not show any clinical improvement or deterioration. There was no incidence of hemorrhage after SRS in any patient and the treatment was well tolerated without any significant complications.Stereotactic radiosurgery for intramedullary spinal AVMs appears to be well tolerated and effective in selected cases.

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