Andrianov A.K.,Apogee Technology Inc. |
Mutwiri G.,University of Saskatchewan
Vaccine | Year: 2012
A vast number of studies explore the potential of intradermal immunization, its role in the developing of new and improved vaccines and providing access to them globally. The advancement of microneedle technology offers new avenues for the practical realization of this approach, but, on certain instances, introduces new limitations and challenges in the formulation development, which involve the concern over its compatibility with existing and emerging immunoadjuvants. The present paper attempts to review various aspects of immunoadjuvant enhanced microneedle immunization and focuses on the potential of synthetic biomaterials that can play a multifunctional role in such approach. PCPP, a synthetic polyphosphazene macromolecular compound, is discussed as an example of such material that can potentially enable the technology as a microfabrication agent and a potent intradermal immunoadjuvant. © 2011 Elsevier Ltd. Source
Apogee Technology Inc. | Date: 2006-09-26
Pressure sensors; sensors for measuring gas concentration; sensors for measuring humidity; electronic sensors for measuring radiation; electronic sensors for identifying types of biological materials; electronic chemical detection sensors; electronic components in the nature of micro-electro-mechanical systems, commonly known as MEMS devices, for use in the manufacture of equipment for sensing pressure, gas concentrations, humidity, radiation, biological materials and chemicals.
Apogee Technology Inc. | Date: 2006-05-22
Transdermal patches for use in the prevention and treatment of cardiovascular, dental and periodontal, dermatologic, endocrine and metabolic, gastroinstestinal, genetic, hematologic, hepatic, immunologic, lymphatic, osteologic, neurologic, ophthalmic, psychiatric, reproductive system, respiratory tract, renal, and urinary tract diseases and disorders. Transdermal drug delivery patches sold without medication.
Apogee Technology Inc. | Date: 2004-11-30
Marin A.,Apogee Technology Inc. |
Andrianov A.K.,Apogee Technology Inc.
Journal of Applied Polymer Science | Year: 2011
Microneedles containing sodium carboxymethylcellulose (CMC) formulations were fabricated to include an external chitosan (CS) layer to modulate their hydration profile, an important parameter affecting their application as intradermal delivery devices and their storage. The microfabrication process was carried out under conditions that enabled the formation of polyelectrolyte complexes between these oppositely charged macromolecules. CMC-CS microneedles were characterized by water uptake in a humid environment, contact angle measurements, dissolution in aqueous solutions, and protein-release profiles. The results demonstrate that the microneedles containing CMC-CS formulations displayed suppressed moisture sensitivity in water vapors compared to their unmodified CMC counterparts while the maintaining quick protein-release characteristics required for their uses. This approach also showed the potential for sustained protein-release applications, as the CMC-CS formulations could be combined in layers to fabricate multicompartment microneedle coatings with delayed release characteristics. © 2011 Wiley Periodicals, Inc. Source