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Andritoiu C.V.,Apitherapy Medical Center | Andritoiu C.V.,Technical University Gheorghe Asachi | Andritoiu C.V.,Vasile Goldis Western University of Arad | Andritoiu V.,Apitherapy Medical Center | And 4 more authors.
Romanian Journal of Morphology and Embryology | Year: 2014

The present paper aimed to evaluate the influence of apitherapy diet in Wistar rats with carbon tetrachloride induced hepatotoxicity, by the means of biochemical determinations and histopathological changes of liver, spleen, pancreas and testicular tissue. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution), 2 mL per 100 g, every two days, for two weeks. Hepatoprotection was achieved with two-apitherapy diet formulations (containing honey, pollen, propolis, Apilarnil, with/without royal jelly), that have been administered for six up to nine weeks. The biochemical results revealed that the two-apitherapy diet formulations had a positive effect improving the enzymatic, lipid, and protein profiles, coagulation, mineral parameters and also the bilirubin levels, after six weeks of treatment. The histopathological results demonstrated the benefit of the two-apitherapy diet formulations on reducing the toxicity of liver, spleen and pancreas in laboratory animals, after six and nine weeks, respectively. In conclusion, apitherapy products have a hepatoprotective effect in carbon tetrachloride-induced hepatopathy. © 2014 ROMANIAN ACADEMY PUBLISHING HOUSE. All rights reserved.


Andritoiu C.V.,Vasile Goldis Western University of Arad | Andritoiu C.V.,Technical University Gheorghe Asachi | Andritoiu C.V.,Apitherapy Medical Center | Bartic M.,Apitherapy Medical Center | And 2 more authors.
Annals of the Romanian Society for Cell Biology | Year: 2015

The aim of this experiment is to study the therapeutic effect on cutaneous incision wounds of a new ointment based on lyophilized albumin extracted from egg. The therapeutical assessments of the proposed ointment were carried out in vivo on the skin linear incisions induced on Wistar rat. The wounds were treated topically once a day, during 21 days. Clinical and macroscopic tests, tissue epitalization time and histopathological examination were assessed. The experimental results showed that the novel lyophilized albumin ointment had a significant healing effect on the incision-type skin lesions. © The Romanian Society for Cell Biology.


Andritoiu C.V.,Vasile Goldis Western University of Arad | Andritoiu C.V.,Technical University Gheorghe Asachi | Andritoiu C.V.,Apitherapy Medical Center | Bartic M.,Apitherapy Medical Center | And 2 more authors.
Annals of the Romanian Society for Cell Biology | Year: 2015

This experiment studies the therapeutic effect of a new ointment based on lyophilized albumin extracted from egg on cutaneous excision lesion. The therapeutical assessments of the proposed ointment were done in vivo on the excisions excided on Wistar rat. The wounds were treated topically once a day, along 21 days. Clinical and macroscopic tests, tissue epitalization time wound contraction rate and histopathological examination were evaluated. The analyzes results revealed a significant healing effect of the new lyophized-albumin on the skin excision lesions by stimulation of the regeneration and the maturation of granulation tissue, antiinflammatory effect, collagenation effect at the lesion site resulting an incision-like mark hard to be seen without vicious healing in terms of both the clinic, macroscopic and histological point of view. © The Romanian Society for Cell Biology.


Andritoiu C.V.,Apitherapy Medical Center | Andritoiu C.V.,Technical University Gheorghe Asachi | Andritoiu C.V.,Vasile Goldis Western University of Arad | Ochiuz L.,Grigore T. Popa University of Medicine and Pharmacy | And 2 more authors.
Molecules | Year: 2014

The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders. The present paper aims to evaluate the influence of the apitherapy diet in Wistar rats with carbon tetrachloride-induced hepatotoxicity, by analyzing the biochemical determinations (enzymatic, lipid and protein profiles, coagulation parameters, minerals, blood count parameters, bilirubin levels) and histopathological changes at the level of liver, spleen and pancreas. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution). Two mL per 100 g were administered, every 2 days, for 2 weeks. Hepatoprotection was achieved with two apitherapy diet formulations containing honey, pollen, propolis, Apilarnil, with/without royal jelly. Biochemical results reveal that the two apitherapy diet formulations have a positive effect on improving the enzymatic, lipid, and protein profiles, coagulation, mineral and blood count parameters and bilirubin levels. The histopathological results demonstrate the benefits of the two apitherapy diet formulations on reducing toxicity at the level of liver, spleen and pancreas in laboratory animals.

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