Kitakyūshū, Japan
Kitakyūshū, Japan
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PubMed | API Corporation 1 1
Type: Journal Article | Journal: The Journal of organic chemistry | Year: 2011

A highly efficient catalytic system for C-H activation has been worked out that involves inexpensive RuCl(3)xH(2)O and a specific amount of PPh(3). This procedure has been successfully applied to a practical synthesis of angiotensin II receptor blockers (ARBs). The residual ruthenium that existed in the reaction mixture was thoroughly removed by treatment with properly selected metal scavengers. The new process permits ready access to the important class of drugs in a highly atom-economical and sustainable manner.

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