Vista, CA, United States

Aperio Technologies

www.aperio.com
Vista, CA, United States
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Patent
Aperio Technologies | Date: 2013-06-04

Methods and apparatus are provided for computing focus information during scanning digital microscope slide data with a line scan camera. The systems and methods include a dynamically interleaved procedure that works by moving the specimen relative to the objective lens while the height of the objective lens is adjusted relative to the stage. Imagery data is acquired at a plurality of objective lens heights the image data from the objective lens height having maximum contrast is stored and combined into a composite digital image of at least a portion of the specimen.


Patent
Aperio Technologies | Date: 2012-01-20

Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether any of multiple virtual slide images has an out of focus area and is therefore a candidate for manual inspection or rescanning, various focus points used to scan each virtual slide image are used to calculate a best fit surface for each virtual slide image. The best fit surface is then used to determine whether any of the various focus points are outliers. If it is determined that a virtual slide image is associated with outlying focus points, it is identified as a candidate for manual inspection or rescanning.


Patent
Aperio Technologies | Date: 2012-07-12

Systems and methods for standardizing one or more fluorescence scanning instruments to a reference system by separating the effects of drift and normalization. In an embodiment, a drift image comprising an image of a drift reference slide is captured by a system to be standardized. A drift measurement is calculated using the drift image. A first normalization image comprising an image of a normalization slide is also captured by the system to be standardized. A reference normalization image, also comprising an image of the normalization slide, is captured by a reference system. The first normalization image is compared to the reference normalization image to determine a gamma value and offset value for the system to be standardized.


Patent
Aperio Technologies | Date: 2012-01-10

Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.


Systems and methods for microscope slide scanning using multiple sensor arrays that receive imagery data from a single optical axis are provided. A single, high quality, easily obtained microscope objective lens is used to project an image onto two or more sensor arrays. The sensor arrays can be linear or two dimensional and imaging takes place along a single optical axis. Simultaneous sensor acquisition and parallel data processing reduce the image acquisition time by a factor of N, where N represents the number of sensors employed.


Patent
Aperio Technologies | Date: 2012-04-23

Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves the quality of a digital slide. The improved digital slide image has a higher image quality that results in increased efficiency and accuracy in the analysis and diagnosis of such digital slides when they are reviewed on a monitor by a pathologist. These improved digital slides yield a more objective diagnosis than reading the corresponding glass slide under a microscope.


Patent
Aperio Technologies | Date: 2012-05-29

Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images (3D digital slides) are provided. An image library module provides access to the imagery data in a 3D digital slide and constructs 3D image objects that are coextensive with the 3D digital slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D digital slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.


Patent
Aperio Technologies | Date: 2013-02-20

Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.


Patent
Aperio Technologies | Date: 2013-03-15

Medical image based collaboration system and methods are provided. A collaboration server 40 creates a medical image based case in response to a request from a requesting system 10 and populates the case with the minimum required information comprising at least a digital medical image and a case number. The collaboration server 40 provides the medical image based case to a consulting system 30 and receives analysis information in response. The collaboration server 40 stores the analysis information in association with the medical image based case and provides the analysis information to the consulting system 30 to complete the medical image based collaboration.


Patent
Aperio Technologies | Date: 2013-06-18

A system and method for processing and analyzing virtual microscopy digital images (digital slides) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.

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