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Patent
APEPTICO Forschung und Entwicklung | Date: 2015-03-17

Disclosed is a dry-powder peptide medicament with a non-typical concentration of carbohydrate excipient, as well as said medicament for use in treatment or prevention of a disease or condition, as well as methods for manufacturing said medicament.


Patent
APEPTICO Forschung und Entwicklung | Date: 2017-01-11

A cyclized compound of the amino acid sequence of formula X1 -GQRETPEGAEAKPWY-X2 wherein X1 comprises an amino acid (sequence) with 1 to 4, in particular 1 to 3 members, comprising natural or unnatural amino acids, in particular selected from the amino acid (sequence) C, KSP, K, ornithin, 4-amino butanoic acid, -alanine, and X2 comprises one amino acid, selected from natural amino acids, in particular selected from the group C, D, G and E, and wherein X comprises the N-terminal amino acid at ist first left position and X2 comprises the C-terminal amino acid at its last right position, optionally in the form of a salt for use in the treatment of inflammation, a pharmaceutical composition for treating inflammation comprising such compound and a method of treating inflammation comprising administering an effective amount of such compound to a mammal in need thereof.


A method of conditioning/improving lung functions extracorporeally by treatment of a lung ex vivo with a cyclized compound of the amino acid sequence of formula X_(1)-GQRETPEGAEAKPWY-X_(2)I wherein X_(1 )comprises an amino acid (sequence) with 1 to 4 members, comprising natural or unnatural amino acids, and X_(2 )comprises one amino acid, selected from natural amino acids; and a pharmaceutical composition, comprising a peptide of formula I as defined in any one of claims 1 to 7, in a form, which is appropriate for spraying to obtain an aerosol for inhalation, or which is appropriate for the preparation of a spray to obtain an aerosol upon spraying, which is appropriate for inhalation.


Patent
APEPTICO Forschung und Entwicklung | Date: 2011-01-12

A cyclic organic compound which comprises 16 amino acids or 17 amino acids and has no carboxyl group C-terminally and/or no amino group N-terminally. Optionally, one of the amino acids is a normatural amino acid. The ring closure is formed between a side chain of one amino acid and the C-terminus of another amino acid, or the ring closure is effected with the aid of a normatural amino acid. A process for producing and using the compound for regulating vectorial ion channels, for treating diseases associated with the lung function and for treating oedemas is provided.


Patent
APEPTICO Forschung und Entwicklung | Date: 2014-03-07

A peptide is described, which consists of 7-17 adjacent amino acids and comprises the hexamer TXEXXE, wherein X, X and X can be any natural or non-natural amino acid, wherein the peptide has no TNF receptor binding activity and is cyclized, for the prevention and treatment of hyperpermeability of epithelial cells and endothelial cells.


Patent
APEPTICO Forschung und Entwicklung | Date: 2011-12-21

A peptide consisting of 7-17 amino acids and including the adjacent hexamer TX_(1)EX_(2)X_(3)E, where X_(1), X_(2) and X_(3) can be any natural or non natural amino acid, wherein the peptide does not exhibit TNF-receptor-binding activity and is cyclic, for the treatment or prevention of vascular complications in diabetes patients.


What is described is a peptide which consists of 7-20, especially 7-17, adjacent amino acids and comprises the hexamer TX_(1)EX_(2)X_(3)E where X_(1), X_(2 )and X_(3 )may be any natural or unnatural amino acid, where the peptide does not have any TNF receptor binding activity and is cyclized, for use for the treatment and avoidance of the pulmonary form of altitude sickness.


Patent
APEPTICO Forschung und Entwicklung | Date: 2015-03-04

A cyclized compound of the amino acid sequence of formula wherein X_(1 )comprises an amino acid (sequence) with 1 to 4, in particular 1 to 3 members, comprising natural or unnatural amino acids, in particular selected from the amino acid (sequence) C, KSP, K, ornithin, 4-amino butanoic acid, -alanine, and X_(2 )comprises one amino acid, selected from natural amino acids, in particular selected from the group C, D, G and E, and wherein X_(1 )comprises the N-terminal amino acid at ist first left position and X_(2 )comprises the C-terminal amino acid at its last right position, optionally in the form of a salt for use in the treatment of inflammation, a pharmaceutical composition for treating inflammation comprising such compound and a method of treating inflammation comprising administering an effective amount of such compound to a mammal in need thereof.


Patent
APEPTICO Forschung und Entwicklung | Date: 2011-11-15

Described is a composition comprisinga peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TX_(1)EX_(2)X_(3)E, where X_(1), X_(2 )and X_(3 )can be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, andan inhibitor of viral neuraminidase.


Patent
APEPTICO Forschung und Entwicklung | Date: 2014-04-18

Cyclic peptide of formula whereinX_(1 )comprises an amino acid (sequence), with 1 to 4 members, comprising natural and unnatural amino acids, and X_(2 )comprises a natural amino acid, and wherein X_(1 )comprises the N-terminal amino acid left in position 1, and X_(2 )the C-terminal amino acid in the ultimate, right position, in the form of a lyophilisate without additives and/or stabilizers and its use.

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