Entity

Time filter

Source Type

Wrocław, Poland

Cytarska J.,Nicolaus Copernicus University | Skowerski K.,Nicolaus Copernicus University | Skowerski K.,Apeiron Synthesis SA | Jaworski S.,Nicolaus Copernicus University | And 3 more authors.
Letters in Drug Design and Discovery | Year: 2015

Novel disulfide analogues of isophosphoramide mustard (iPAM) were designed and synthesised. All compounds were hydrolytically stable and underwent reduction by L-glutathione with different kinetic parameters. Based on the HPLC-MS analysis a mechanism of activation by glutathione obtained disulfide analogues of iPAM was proposed. The compounds were tested for cytotoxic activity against human promyelocytic leukaemia HL-60, human lymphoblastic leukaemia MOLT-4, human lymphoblastic leukaemia CCRF/CEM, human bladder cancer HCV29T, murine melanoma B16-F0 and murine fibroblasts Balb3T3 cell lines. The most promising anticancer activity was exhibited by compound 4, which proved to be more active than the reference cisplatin against all cancer cell lines. © 2015 Bentham Science Publishers. Source


Kozlowska A.,University of Warsaw | Dranka M.,Warsaw University of Technology | Zachara J.,Warsaw University of Technology | Pump E.,University of Graz | And 3 more authors.
Chemistry - A European Journal | Year: 2014

Cyclic Ru-phenolates were synthesized, and these compounds were used as olefin metathesis catalysts. Investigation of their catalytic activity pointed out that, after activation with chemical agents, these catalysts promote ring-closing metathesis (RCM), enyne and cross-metathesis (CM) reactions, including butenolysis, with good results. Importantly, these latent catalysts are soluble in neat dicyclopentadiene (DCPD) and show good applicability in ring-opening metathesis polymeriyation (ROMP) of this monomer. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


This disclosure relates to new metal complexes, such as compounds of Formula 1, and their application in olefin or alkyne metathesis and to methods of carrying out olefin metathesis reactions.


This disclosure relates to new metal complexes, such as compounds of Formula 1, and their application in olefin or alkyne metathesis and to methods of carrying out olefin metathesis reactions.


The invention is related to the metal complexes of the general formula (1). The invention is related also to the use of metal complexes of the formula 1 as (pre)catalysts for the olefin metathesis reactions, as well as to the process for carrying out the olefin metathesis reaction.

Discover hidden collaborations