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Wrocław, Poland

Olszewski T.K.,Apeiron Catalysts | Bieniek M.,Apeiron Catalysts | Skowerski K.,Apeiron Catalysts | Grela K.,Polish Academy of Sciences | Grela K.,University of Warsaw
Synlett | Year: 2013

This account describes the discovery and development of efficient electron-withdrawing group activated Hoveyda-Grubbs catalysts, including a nitro-substituted catalyst and their applications in the syntheses of complex molecules. 1 Introduction 2 EWG-Activated Hoveyda-Grubbs Complexes 2.1 The Discovery and the Story Behind It 2.2 The Nitro-Substituted Hoveyda-Grubbs Catalyst 2.3 pH-Responsive Catalysts 2.4 Fine-Tuning of the EWG Fragment 3 Applications of the Nitro-Substituted Hoveyda-Grubbs Catalyst in the Preparation of Compounds of Biological Relevance 3.1 Synthesis of BILN 2061 4 Concluding Remarks. © Georg Thieme Verlag Stuttgart . New York.

Skowerski K.,Apeiron Catalysts | Czarnocki S.J.,Apeiron Catalysts | Knapkiewicz P.,Wroclaw University of Technology
ChemSusChem | Year: 2014

A tube-in-tube reactor was successfully applied in homo- and heterogeneous olefin metathesis reactions under continuous flow mode. It was shown that the efficient removal of ethylene facilitated by connection of the reactor with a vacuum pump significantly improves the outcome of metathesis reactions. The beneficial aspects of this approach are most apparent in reactions performed at low concentration, such as macrocyclization reactions. The established system allows achievement of both improved yield and selectivity, and is ideal for industrial applications. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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