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Dhingra V.,Apeejay Stya University | Bhatia K.,YMCA University of Science and Technology
International Journal of Information Technology and Web Engineering | Year: 2012

Ontologies are the backbone of knowledge representation on Semantic web. Challenges involved in building ontologies are in terms of time, efforts, skill, and domain specific knowledge. In order to minimize these challenges, one of the major advantages of ontologies is its potential of "reuse," currently supported by various search engines like Swoogle, Ontokhoj. As the number of ontologies that such search engines like Swoogle, OntoKhoj Falcon can find increases, so will the need increase for a proper ranking method to order the returned lists of ontologies in terms of their relevancy to the query which can save a lot of time and effort. This paper deals with analysis of various ontology ranking algorithms. Based on the analysis of different ontology ranking algorithms, a comparative study is done to find out their relative strengths and limitations based on various parameters which provide a significant research direction in ranking of ontologies in semantic web. Copyright © 2012, IGI Global.


Mahajan R.,Manav Rachna International University | Mahajan R.,Apeejay Stya University | Bansal D.,Manav Rachna International University
ICROIT 2014 - Proceedings of the 2014 International Conference on Reliability, Optimization and Information Technology | Year: 2014

Electrocardiogram (ECG) is a primary clinical diagnostic tool for detection of cardiac arrhythmias. As ECG signals are generally acquired over longer time periods at extremely high resolution and thus are highly data intensive. This leads to the requirement of large storage space for database construction and more transmission bandwidth for remote ECG signal analysis, respectively. Successive ECG beats and sample values however, show some redundancy along with the information content. By removing this redundancy, ECG signal compression can be achieved. This paper comprises implementation of hybrid ECG signal compression system based on frequency transformation and parameter extraction techniques. It uses discrete cosine transform (DCT) and Fast Fourier transform (FFT) to compress the ECG signal. This compressed ECG signal is embedded with corresponding heart rate information in order to obtain a high quality reconstructed signal required for accurate cardiac state diagnosis. The proposed algorithm is tested for compression of bradycardia and tachycardia ECG rhythms selected from MIT-BIH arrhythmia database and the performance is evaluated using compression ratio and percent root-mean-square difference (PRD). The high compression ratio, low reconstruction error and less computational complexity justify the efficiency of hybrid techniques in ECG signal compression and thus in telecardiology © 2014 IEEE.


Kaur G.,Apeejay Stya University | Mahajan M.P.,Apeejay Stya University | Mahajan M.P.,Institutional Area | Pandey M.K.,Penn State College of Medicine | And 3 more authors.
European Journal of Medicinal Chemistry | Year: 2014

The synthesis of some novel Ospemifene derived analogs and their evaluation as anti-breast cancer agents against MCF-7 (ER-positive) and MDA-MB-231 (ER-negative) human breast cancer cell lines are described. Few of these analogs for instance, compounds 6, 7 and 8 are shown to be more effective than recent Selective Estrogen Receptor Modulators (SERMs) i.e. Ospemifene and Tamoxifen, against these cell lines. Compound 8 was relatively more cytotoxic to MCF-7 cells similar to Ospemifene and Tamoxifen, while most potent compounds 6 and 7 were equally effective in inhibiting growth of both ER-positive and ER-negative cell lines. The observed activity profiles were further supported by the docking studies performed against estrogen receptors (ERα and ERβ). Compounds 6, 7 and 8 exhibited stronger binding affinities with both ERα and ERβ compared to Ospemifene and Tamoxifen. © 2014 Elsevier Masson SAS. All rights reserved.


Mahajan A.,Apeejay Stya University | Hans R.,University of Namibia | Chibale K.,Apeejay Stya University | Chibale K.,University of Cape Town | Kumar V.,Guru Nanak Dev University
RSC Advances | Year: 2014

Despite advances in molecular methods for the diagnosis of tuberculosis (TB) and its resistant forms, it remains more prevalent in the world today than at any other time in human history. Of equal concern is the slow moving antitubercular drug development pipeline which calls for research efforts to be intensified and directed towards the discovery of new molecular scaffolds and/or the remodelling of some old TB drug families. In support of the latter, this review highlights synthetic methodologies and structure activity relationships (SARs) elaborated for natural products and/or natural product derivatives with promising antitubercular activity. It further attests to the enormous potential of natural products in the antitubercular drug discovery process. © the Partner Organisations 2014.


Jindal V.,Apeejay Stya University | Bawa S.,Thapar University | Batra S.,Thapar University
Information Processing and Management | Year: 2014

With ever increasing information being available to the end users, search engines have become the most powerful tools for obtaining useful information scattered on the Web. However, it is very common that even most renowned search engines return result sets with not so useful pages to the user. Research on semantic search aims to improve traditional information search and retrieval methods where the basic relevance criteria rely primarily on the presence of query keywords within the returned pages. This work is an attempt to explore different relevancy ranking approaches based on semantics which are considered appropriate for the retrieval of relevant information. In this paper, various pilot projects and their corresponding outcomes have been investigated based on methodologies adopted and their most distinctive characteristics towards ranking. An overview of selected approaches and their comparison by means of the classification criteria has been presented. With the help of this comparison, some common concepts and outstanding features have been identified. © 2013 Elsevier Ltd. All rights reserved.


Wang Y.,University of Arizona | Saha B.,Apeejay Stya University | Li F.,University of Arizona | Frett B.,University of Arizona | Li H.-Y.,University of Arizona
Tetrahedron Letters | Year: 2014

An expeditious cascade protocol for the synthesis of functionalized imidazo[1,2-a]pyridin-3-ols was developed based on the Petasis reaction. With the availability of commercial reagents and high efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of imidazo-pyridin-3-ol analogues. © 2014 Elsevier Ltd. All rights reserved.


Kar S.,National Institute of Pharmaceutical Education and Research | Kar S.,Apeejay Stya University | Patel M.A.,National Institute of Pharmaceutical Education and Research | Patel M.A.,Purdue University | And 3 more authors.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids | Year: 2013

Paraoxonase 1 (PON1) is an HDL-associated enzyme and exhibits anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Association of PON1 to HDL particles increases the stability and activity of PON1 and is important for the normal functioning of the enzyme. HDL particles are made up of lipid and protein constituents and apolipoprotein A-I (apoA-I) is a principal protein constituent of HDL that facilitates various biological activities of HDL. In many disease conditions the oxidized phospholipid (Ox-PL) content of HDL is found to be increased and an inverse correlation between the activity of PON1 and oxidation of the HDL is observed. However, the molecular details of the inhibitory action of the Ox-PL-containing HDL on the function of PON1 are not clear yet. In this study we have assembled reconstituted HDL (rHDL) particles with and without Ox-PL and compared their effect on the structure and function of 13C-labeled recombinant PON1 (13C-rPON1) by employing attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy and enzymatic assay. Our results show that the presence of the Ox-PL in the rHDL particles alters the structure of rPON1 and decreases its lactonase activity. © 2013 Elsevier B.V.


Kumar A.,Apeejay Stya University
E-Journal of Chemistry | Year: 2011

The triplex formation of disulphide containing oligonucleotide with duplex DNA using melting temperature studies is reported. The stability of the triplex formed with disulphide containing oligonucleotide was compared with unmodified oligonucleotide and C-5 propyne deoxyuridine containing oligonucleotide. Melting temperature (Tm) values of the triplexes formed with disulphide containing oligonucleotide were found to be 37 oC and 46 oC at pH 7 and 6 respectively. The triplexes formed with C-5 propyne deoxyuridine substituted oligonucleotide showed Tm values at 27 oC and 42 oC at pH 7 and 6. The Tm values of the triplexes formed with unmodified oligonucleotide were found to be 18 oC and 32 oC at pH 7 and 6 respectively. This clearly demonstrates that disulphide containing oligonucleotide stabilzes triplex DNA structure better than unmodified oligonucleotide as well as C-5 propyne deoxyuridine containing oligonucleotide when targeted with duplex DNA at both the mentioned pH values.


Kumar A.,Apeejay Stya University
E-Journal of Chemistry | Year: 2011

The small dumbbell oligonucleotides containing loops of phosphodiester (OL-1), two trimethylene, C3 moieties in each loop (OL-2) and phosphorothioate (OL-3) linkages were synthesized. Incubation of OL-1 and OL-2 with S-1 nuclease generated break down products whereas incubation of OL-3 did not result in significant cleavage. Their binding to moloney murine leukemia virus reverse transcriptase was evaluated by PAGE band mobility shift assays. The OL-3 bound more strongly to the reverse transcriptase than OL-1 and OL-2. The dissociation constants evaluated using PAGE band mobility shift assays were of the order of 10-7. Investigation of inhibition of RNase H activity of reverse transcriptase showed that the OL-3 is a better inhibitor of the retroviral RNase H activity than both OL-1 and OL-2. Thus OL- 3 may be used as RNase H inhibitor. Our studies demonstrated that this particularly designed oligonucleotide (OL-3) displays an IC50 of 25 nM in its inhibition on the reverse transcriptase RNase H activity, a magnitude lower than that of first nucleotide reverse transcriptase of HIV-1, tenofovir, introduced by Gilead Science in the market.


Manchanda S.,Delhi Institute of Pharmaceutical science and Research DIPSAR | Sahoo P.K.,Delhi Institute of Pharmaceutical science and Research DIPSAR | Majumdar D.K.,Apeejay Stya University
Nanotechnology Reviews | Year: 2016

Chitosan-dextran sulfate nanoparticles of acetazolamide were formulated by using the ionic gelation technique, and evaluated for different attributes like particle size, ζ potential, drug entrapment, particle morphology, in vitro drug release, and in vivo efficacy. Particle size was observed to be changed with the increment of the drug/polymer ratio. Sustained in vitro drug release was exhibited by the particulate formulation that followed the Korsmeyer-Peppas kinetic model. Drug release from nanoparticles was found to occur, as shown by the results, through a combination of dissolution and diffusion. The optimized formulation had a particle size of 172.3 nm and ζ potential of 36.46 mV. The particles had a spherical shape and polydispersity index of 0.257. Decrease in crystallinity of the drug was indicated by powder X-ray diffraction and differential scanning calorimetry studies, in the optimized nanoparticle formulation. Approximately 2.5 times higher transcorneal permeation of drug was observed across the excised goat cornea, in comparison to the aqueous solution of drug, without any corneal damage, during ex vivo transcorneal studies. In vitro mucoadhesion studies showed 91.59% mucoadhesion. The in vivo studies involving ocular hypotensive activity in rabbits revealed significantly higher hypotensive activity with a p-value of <0.05, in contrast to a plain drug solution, with no signs of ocular irritation. The stability studies showed that the formulation was rather stable. © 2016 Walter de Gruyter GmbH, Berlin/Boston 2016.

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