Lone Tree, IA, United States
Lone Tree, IA, United States

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Peace R.M.,North Carolina State University | Campbell J.,APC Inc. | Polo J.,APC Inc. | Crenshaw J.,APC Inc. | And 2 more authors.
Journal of Nutrition | Year: 2011

The objective of this study was to evaluate the effects of dietary inclusion levels of spray-dried porcine plasma (SDPP) on postweaning (PW) intestinal barrier function, mucosal inflammation, and clinical indices of gut health in pigs. Ex vivo Ussing chamber studies were conducted to measure Ileal and colonic barrier function in terms of transepithelial electrical resistance and paracellular flux of 3H-mannitol and 14C-inulin. Intestinal inflammation was assessed by histological analysis and mucosal levels of proinflammatory cytokines. Dietary inclusion of 2.5 and 5% SDPP reduced colonic paracellular permeability of 14C-inulin compared with controls (0% SDPP) on d 7 PW. Both 2.5 and 5% dietary SDPP reduced ileal 3H-mannitol and 14C-inulin permeability on d 14 PW. The 5% SDPP diet reduced colonic short-circuit current, an index of net electrogenic ion transport, and fecal scores when measured on d 7 and 14 PW compared with the control and 2.5% SDPP groups (P < 0.05). Histological analysis revealed fewer lamina propria cells in ileum and colon from pigs fed diets containing 2.5 and 5% SDPP on d 7 and 14 PW. Levels of the proinflammatory cytokine TNFα were reduced in the colon but not ileum from pigs fed the 5% SDPP on d 7 and 14 PW compared with controls (P < 0.05). IFNγ levels were lower than in controls in both of the SDPP-fed groups in the ileum and colon on d 7 but not on d 14 PW. Overall, this study demonstrated that dietary inclusion of SDPP had beneficial effects on intestinal barrier function, inflammation, and diarrhea in weaned pigs. © 2011 American Society for Nutrition.


Campbell J.M.,APC Inc. | Crenshaw J.D.,APC Inc. | Polo J.,APC Inc.
Journal of Animal Science and Biotechnology | Year: 2013

Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig's life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality. © 2013 Campbell et al.; licensee BioMed Central Ltd.


Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglubulin or plasma fractions purified from animal serum can modulate serum IgG and/or TNF- levels for treatment of autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.


The present invention provides methods for feeding older sows that beneficially reduce feed intake in older sows, yet improve pig survival and weaning weight of pigs from older sows.


The present invention provides methods for feeding older sows that beneficially reduce feed intake in older sows, yet improve pig survival and weaning weight of pigs from older sows.


The present invention provides methods for feeding older sows that beneficially reduce feed intake in older sows, yet improve pig survival and weaning weight of pigs from older sows.


Trademark
APC Company | Date: 2014-09-18

Nutritional feed supplement for equids, namely horses, mules and donkeys.


Trademark
APC Company | Date: 2013-09-12

Powdered, liquid, pellet or paste nutritional feed supplement for equids, namely horses and donkeys. Powdered, liquid, pellet or paste nutritional feed replacement or food treat for equids, namely horses and donkeys.


Trademark
APC Company | Date: 2013-11-12

Powdered, liquid, pellet or paste nutritional feed supplement, feed replacer or treat for ruminants, namely cattle, goats, sheep, llamas, alpacas and deer; equids, namely horses and donkeys; companion animals, namely dogs and cats; and swine.


Nutritional feed supplement in powdered, liquid, paste or pellet form for ruminants, namely cattle, sheep, llamas, alpacas and deer, equids, namely horses and donkeys and swine. Feed replacer and food treat in powdered, liquid, paste or pellett form for ruminants, namely cattle, sheep, llamas, alpacas and deer, equids, namely horses and donkeys and swine.

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