Aomori Shi, Japan

Aomori University of Health and Welfare is a public university in the city of Aomori, Aomori Prefecture Japan. The school was established in 1999. The school is a Facility of Heath science, with departments of nursing, physical therapy and social welfare. Wikipedia.

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Inoue S.,Tokyo Medical University | Ohya Y.,Tokyo Medical University | Tudor-Locke C.,Pennington Biomedical Research Center | Tanaka S.,National Institute of Health and Nutrition | And 2 more authors.
Medicine and Science in Sports and Exercise | Year: 2011

Purpose: The study's purpose was to describe the most recently reported (2007) step-determined physical activity and trends from 1995 to 2007 among Japanese adults. Methods: Data were extracted from published reports of the Japan Heath and Nutrition Survey, which has been conducted annually by the Ministry of Health, Labour and Welfare of Japan using a nationally representative Japanese adult sample of 6502-9833 participants (≥20 yr) each year. Pedometer data were collected on an individually specified weekday in November each year. Because of the change in age distribution of the sample, steps per day were adjusted by age to examine time trends. Results: Men took 7321 ± 4588 (mean ± SD) steps per day and women took 6267 ± 3827 steps per day in the Japan Heath and Nutrition Survey 2007. Men took more steps per day than women in all age groups. Steps per day were lower with older age groups among men, whereas among women, the 40-to 49-yr-old age group took the highest steps per day relative to other ages. Time trends displayed a decline of age-adjusted mean steps per day (-529 steps per day among men and-857 steps per day among women) from peak values in 1998-2000 to 2007. Decreases in percent of people classified as active (age-adjusted proportion taking≥10,000 steps per day =-5.1% among men and-5.0% among women) and increases in percent classified as sedentary (age-adjusted proportion taking <4000 steps per day = +4.8% among men and +8.2% among women) were also observed during the same period. Conclusions: Japanese steps per day have decreased over time from a peak around 1998-2000. The increase in the percent taking <4000 steps per day was especially noticeable among women. © 2011 by the American College of Sports Medicine.

Oyama H.,Aomori University of Health and Welfare | Sakashita T.,Aomori University of Health and Welfare
American Journal of Geriatric Psychiatry | Year: 2016

Objectives To explore the long-term impact of a universal screening intervention for depression on suicide rates among older community-dwelling adults, with gender as an effect modifier. Design Controlled cohort study reporting long-term follow-up of previous research. Setting Two sets of three municipalities in Japan were assigned as intervention and control regions and compared with the surrounding zone and prefecture. Participants Intervention area residents aged 60 years and older (14,291) were invited to participate in a 2-year intervention (2005-2006). Four population-based dynamic cohorts of residents aged 65 years and older (1999-2010) were included as subjects, 6 years before and after the intervention started. Intervention At-risk residents within the intervention region (4,918) were invited for a two-step screening program; 2,552 participated in the program linked with care/support services for 2 years. An education program open to the public was held. Measurements Changes in suicide from a 6-year baseline to the 2-year intervention and a 4-year follow-up in the intervention region (11,700 adults ≥65 years) were compared with a matched control and two comparison areas using mixed-effects negative binomial regression models. Suicide rates among older adults exposed to screening were compared with those of the control region. Results Suicide rates in the intervention region decreased by 48%, which was significantly greater than in the three comparison areas. The program's benefits lasted longer for women than men. Screening exposure may be associated with decreased suicide risk over the 4-year follow-up. Conclusions Universal screening may decrease suicide rates among older adults, with potential gender differences in treatment response. © 2016 American Association for Geriatric Psychiatry.

Mukai Y.,Aomori University of Health and Welfare | Sato S.,Aomori University of Health and Welfare
Journal of Nutritional Biochemistry | Year: 2011

We investigated the effects of azuki bean (Vigna angularis) seed coats (ABSC), which contain polyphenols, on the vascular oxidative stress and inflammation associated with hypertension. Spontaneously hypertensive rats (SHR) and control normotensive Wistar-Kyoto (WKY) rats were divided into 2 groups each. One group was fed 0% ABSC; the other, a 1.0% ABSC-containing diet. Tail systolic blood pressure (SBP) was examined throughout ABSC treatment. At 8 weeks, vascular superoxide (O2 -) production was measured by lucigenin-enhanced chemiluminescence. mRNA expressions of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, macrophage chemoattractant protein-1 (MCP-1) and its receptor C-C chemokine receptor 2 (CCR2) in the aorta were analyzed by reverse transcriptase-polymerase chain reaction. Protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were determined by western blotting. Polyphenol-containing ABSC suppressed the elevation of SBP throughout the treatment period. The NADPH-stimulated O2 - level decreased significantly in the aorta of ABSC-treated SHR compared with the level of untreated SHR. The p47phox and Nox4 mRNA expression increased significantly in untreated SHR compared with that in WKY rats. Conversely, the level of p47phox mRNA was significantly lower in ABSC-treated SHR than in untreated SHR. The protein abundance of both iNOS and COX-2 was significantly decreased in the aorta of the ABSC-treated SHR compared with this abundance in untreated SHR. The MCP-1 and CCR2 mRNA expressions increased in untreated SHR, and these levels were significantly lower in ABSC-treated SHR. In conclusion, our results suggested that polyphenol-containing ABSC could attenuate vascular oxidative stress and inflammation during the progression of hypertension, and this may lead to an improvement in hypertension. © 2011 Elsevier Inc.

Yoshiike N.,Aomori University of Health and Welfare
Nihon rinsho. Japanese journal of clinical medicine | Year: 2013

Prevalence of obesity (BMI > or = 30) in Japanese adults (aged 20 years and over) was 3.8% in males and 3.2% in females (National Health and Nutrition Survey, 2010), being quite low compared with other countries listed in the Global Database on Body Mass Index (WHO). On the other hand, prevalence of overweight (BMI > or = 25) was 30.4% in males and 21.1% in females, of which overweight in males has increased in recent 35 years almost twice from 15% to 30%. Although the prevalence of overweight and obesity in Japanese adults is rather low in international comparisons, control for the obesity-associated risks through the promotion of appropriate body weight management has been prioritized in the national health programs.

Sato S.,Aomori University of Health and Welfare | Mukai Y.,Aomori University of Health and Welfare | Saito T.,Hokkaido University
Journal of Nutritional Biochemistry | Year: 2013

Quercetin, a naturally occurring flavonoid, has been reported to possess numerous biological activities including activation of adenosine-5'-monophosphate-activated protein kinase (AMPK). We investigated the effects of quercetin intake during lactation on the AMPK activation in the livers of adult offspring programmed by maternal protein restriction during gestation. Pregnant Wistar rats were fed control and low-protein diets during gestation. Following delivery, each dam received a control or 0.2% quercetin-containing control diet during lactation as follows: control on control (CC), control on restricted (LPC) and 0.2% quercetin-containing control on restricted (LPQ). At weaning (week 3), some of the pups from each dam were killed, and the remaining pups (CC, n= 8; LPC, n= 10; LPQ, n= 13) continued to receive a standard laboratory diet and were killed at week 23. Blood chemistry and phosphorylation levels of AMPKα, acetyl-CoA carboxylase (ACC), endothelial nitric oxide synthase (eNOS) and mammalian target of rapamycin (mTOR) in the livers of male offspring were examined. At week 3, the level of phosphorylated AMPK protein in LPQ increased about 1.5- and 2.1-fold compared with LPC and CC, respectively, and the level in LPQ at week 23 increased about 1.9- and 2.9-fold, respectively. A significant increase in phosphorylated ACC and eNOS levels was found in LPQ. There was no significant difference among the three groups in the level of phosphorylated mTOR protein. In conclusion, quercetin intake during lactation up-regulates AMPK activation in the adult offspring of protein-restricted dams and modulates the AMPK pathway in the liver. © 2013 Elsevier Inc.

Mukai Y.,Aomori University of Health and Welfare | Sun Y.,Hokkaido University | Sato S.,Aomori University of Health and Welfare
Nutrition | Year: 2013

Objective: Fetal malnutrition is an early-life inducer of dyslipidemia and glucose intolerance. The aim of this study was to examine whether maternal azuki bean (Vigna angularis) polyphenol (AP) intake during lactation affects the adenosine monophosphate-activated protein kinase (AMPK) pathway and lipid metabolism in offspring exposed to fetal malnutrition. Methods: Pregnant Wistar rats were divided into three groups: a control diet offered during gestation and lactation (CC), a low-protein diet during gestation and a control diet during lactation (LPC); and a low-protein diet during gestation and a 1.0% AP-containing control diet during lactation (LPAP). Male pups were randomly selected for the study; half the pups were sacrificed at 3 wk of age and the other half were fed a standard diet and sacrificed at 23 wk. Hepatic triacylglycerol levels, phosphorylation levels of AMPK and acetyl-coenzyme A carboxylase (ACC), and mRNA levels of sterol regulatory element-binding protein-1c (SREBP-1c) were evaluated. Results: Significant decreases in body weights and hepatic triacylglycerol levels were found in the LPAP compared with the LPC group. Plasma adiponectin levels in the LPAP group were higher than those in the LPC group. AMPK phosphorylation was upregulated in the livers and skeletal muscles in young and adult LPAP compared with LPC rats. ACC phosphorylation was upregulated in skeletal muscles of LPAP rats. SREBP-1c mRNA expression was decreased in the livers of LPAP rats. Conclusion: Our results suggest that maternal AP intake during lactation upregulates AMPK phosphorylation not only in young but also in adult offspring exposed to fetal malnutrition and may lead to decreased hepatic lipid accumulation by ACC phosphorylation and downregulation of SREBP-1c expression. © 2013 Elsevier Inc.

Ozaki I.,Aomori University of Health and Welfare | Hashimoto I.,Kanazawa Institute of Technology
Clinical Neurophysiology | Year: 2011

A brief review of previous studies is presented on high frequency oscillations (HFOs)>300. Hz overlying the cortical response in the somatosensory evoked potential (SEP) or magnetic field (SEF) in humans as well as other mammals. The characteristics of somatosensory HFOs are described about reproducibility and origin (area 3b and 1) of the HFOs, changes during a wake-sleep cycle, effects of stimulus rate or tactile interference, and pharmacological effects. Also, several hypotheses on the neural mechanisms of the HFOs are reconsidered; the early HFO burst is probably generated from action potentials of thalamocortical fibers at the time when they arrive at the area 3b (and 1), since this component is resistant to higher stimulus rate >10. Hz, general anesthesia, or application of glutamatergic receptor antagonist: by contrast, the late HFO burst is sensitive to higher stimulus rate and eliminated after application of glutamatergic receptor antagonist, reflecting activities of a postsynaptic neural network in areas 3b and 1 of the somatosensory cortex. In view of physiological features of the somatosensory HFOs and their pathological or pharmacological changes, possible mechanisms of the late HFO burst genesis are discussed: a fast-spiking interneuron hypothesis, a fast pyramidal cell IPSP hypothesis and a chattering cell hypothesis. © 2011 International Federation of Clinical Neurophysiology.

Iwabe T.,Aomori University of Health and Welfare | Ozaki I.,Aomori University of Health and Welfare | Hashizume A.,Hiroshima University
Neuroscience Research | Year: 2014

To test the hypothesis that a respiratory cycle influences pain processing, we conducted an experimental pain study in 10 healthy volunteers. Intraepidermal electrical stimulation (IES) with a concentric bipolar needle electrode was applied to the hand dorsum at pain perceptual threshold or four times the perceptual threshold to produce first pain during expiration or inspiration either of which was determined by the abrupt change in an exhaled CO2 level. IES-evoked potentials (IESEPs), sympathetic skin response (SSR), digital plethysmogram (DPG), and subjective pain intensity rating scale were simultaneously recorded. With either stimulus intensity, IES during expiration produced weaker pain feeling compared to IES during inspiration. The mean amplitude of N200/P400 in IESEPs and that of SSR were smaller when IES was applied during expiration. The magnitude of DPG wave gradually decreased after IES, but a decrease in the magnitude of DPG wave was less evident when IES was delivered during expiration. Regardless of stimulus timing or stimulus intensity, pain perception was always concomitant with appearance of IESEPs and SSR, and changes in DPG. Our findings suggest that pain processing fluctuates during normal breathing and that pain is gated within the central nervous system during expiration. © 2014 The Authors.

Mukai Y.,Aomori University of Health and Welfare | Kumazawa M.,Aomori University of Health and Welfare | Sato S.,Aomori University of Health and Welfare
Endocrine | Year: 2013

Excess fructose consumption is associated with the development of type 2 diabetes and obesity. However, the impact of fructose intake on maternal and fetal lipid metabolism during pregnancy is not known. The aim of this study was to examine whether maternal fructose intake during pregnancy would affect fetal and maternal hepatic lipid metabolism. Pregnant Wistar rats were randomly divided into untreated control and fructose-treated groups; the fructose-treated group received fructose via drinking water throughout pregnancy. On gestational day 20, glucose and insulin concentration in the maternal plasma were measured. The mRNA expression of sterol regulatory element-binding protein (SREBP)-1c and its target genes in the liver of dams and fetuses were analyzed by real-time PCR. Significantly higher maternal plasma glucose levels, indicating hyperglycemia, was observed in the fructose-treated group than in the control group. Furthermore, the fructose-treated group showed significantly higher expression levels of both maternal and fetal SREBP-1c mRNA and protein and significantly elevated expression of fatty acid synthase; the group also showed reduced acyl-CoA oxidase levels in the maternal liver. Thus, our results suggest that maternal fructose intake during pregnancy causes maternal hyperglycemia and up-regulates hepatic SREBP-1c expression in both fetuses and dams. This may lead to defects in carbohydrate and lipid metabolism in the adult offspring. © 2012 Springer Science+Business Media New York.

Oyama H.,Aomori University of Health and Welfare | Sakashita T.,Aomori University of Health and Welfare
Journal of Nervous and Mental Disease | Year: 2014

We examined the effect of a community-based screening program on depression in middle-aged individuals. Ten subdistricts constituting a rural township (2400 inhabitants aged 40-64 years) in northern Japan with a high suicide rate were randomly assigned to intervention (four) and control (six) groups. A 2-year depression-screening program entailing identification and subsequent care support was offered to adults aged 40 to 64 years in the intervention group, accompanied by 4-year ongoing dissemination of educational information in both groups. Change in depressive symptom prevalence was assessed through before-and-after cross-sectional surveys using the Center for Epidemiologic Studies-Depression Scale. Of the 900 targeted individuals, 49.2% participated in the screening. Comparison of data from these surveys after controlling for district-level clustering indicated a greater difference in prevalence between baseline and 5-year follow-up in the intervention group than that in the control. Universal screening and subsequent support seem effective to decrease depressive symptom prevalence among middle-aged individuals in a community setting. © 2014 by Lippincott Williams & Wilkins.

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