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Aomori Shi, Japan

Aomori University of Health and Welfare is a public university in the city of Aomori, Aomori Prefecture Japan. The school was established in 1999. The school is a Facility of Heath science, with departments of nursing, physical therapy and social welfare. Wikipedia.

Yoshiike N.,Aomori University of Health and Welfare
Nihon rinsho. Japanese journal of clinical medicine | Year: 2013

Prevalence of obesity (BMI > or = 30) in Japanese adults (aged 20 years and over) was 3.8% in males and 3.2% in females (National Health and Nutrition Survey, 2010), being quite low compared with other countries listed in the Global Database on Body Mass Index (WHO). On the other hand, prevalence of overweight (BMI > or = 25) was 30.4% in males and 21.1% in females, of which overweight in males has increased in recent 35 years almost twice from 15% to 30%. Although the prevalence of overweight and obesity in Japanese adults is rather low in international comparisons, control for the obesity-associated risks through the promotion of appropriate body weight management has been prioritized in the national health programs. Source

Ozaki I.,Aomori University of Health and Welfare | Hashimoto I.,Kanazawa Institute of Technology
Clinical Neurophysiology | Year: 2011

A brief review of previous studies is presented on high frequency oscillations (HFOs)>300. Hz overlying the cortical response in the somatosensory evoked potential (SEP) or magnetic field (SEF) in humans as well as other mammals. The characteristics of somatosensory HFOs are described about reproducibility and origin (area 3b and 1) of the HFOs, changes during a wake-sleep cycle, effects of stimulus rate or tactile interference, and pharmacological effects. Also, several hypotheses on the neural mechanisms of the HFOs are reconsidered; the early HFO burst is probably generated from action potentials of thalamocortical fibers at the time when they arrive at the area 3b (and 1), since this component is resistant to higher stimulus rate >10. Hz, general anesthesia, or application of glutamatergic receptor antagonist: by contrast, the late HFO burst is sensitive to higher stimulus rate and eliminated after application of glutamatergic receptor antagonist, reflecting activities of a postsynaptic neural network in areas 3b and 1 of the somatosensory cortex. In view of physiological features of the somatosensory HFOs and their pathological or pharmacological changes, possible mechanisms of the late HFO burst genesis are discussed: a fast-spiking interneuron hypothesis, a fast pyramidal cell IPSP hypothesis and a chattering cell hypothesis. © 2011 International Federation of Clinical Neurophysiology. Source

Inoue S.,Tokyo Medical University | Ohya Y.,Tokyo Medical University | Tudor-Locke C.,Pennington Biomedical Research Center | Tanaka S.,National Institute of Health and Nutrition | And 2 more authors.
Medicine and Science in Sports and Exercise | Year: 2011

Purpose: The study's purpose was to describe the most recently reported (2007) step-determined physical activity and trends from 1995 to 2007 among Japanese adults. Methods: Data were extracted from published reports of the Japan Heath and Nutrition Survey, which has been conducted annually by the Ministry of Health, Labour and Welfare of Japan using a nationally representative Japanese adult sample of 6502-9833 participants (≥20 yr) each year. Pedometer data were collected on an individually specified weekday in November each year. Because of the change in age distribution of the sample, steps per day were adjusted by age to examine time trends. Results: Men took 7321 ± 4588 (mean ± SD) steps per day and women took 6267 ± 3827 steps per day in the Japan Heath and Nutrition Survey 2007. Men took more steps per day than women in all age groups. Steps per day were lower with older age groups among men, whereas among women, the 40-to 49-yr-old age group took the highest steps per day relative to other ages. Time trends displayed a decline of age-adjusted mean steps per day (-529 steps per day among men and-857 steps per day among women) from peak values in 1998-2000 to 2007. Decreases in percent of people classified as active (age-adjusted proportion taking≥10,000 steps per day =-5.1% among men and-5.0% among women) and increases in percent classified as sedentary (age-adjusted proportion taking <4000 steps per day = +4.8% among men and +8.2% among women) were also observed during the same period. Conclusions: Japanese steps per day have decreased over time from a peak around 1998-2000. The increase in the percent taking <4000 steps per day was especially noticeable among women. © 2011 by the American College of Sports Medicine. Source

Sato S.,Aomori University of Health and Welfare | Mukai Y.,Aomori University of Health and Welfare | Saito T.,Hokkaido University
Journal of Nutritional Biochemistry | Year: 2013

Quercetin, a naturally occurring flavonoid, has been reported to possess numerous biological activities including activation of adenosine-5'-monophosphate-activated protein kinase (AMPK). We investigated the effects of quercetin intake during lactation on the AMPK activation in the livers of adult offspring programmed by maternal protein restriction during gestation. Pregnant Wistar rats were fed control and low-protein diets during gestation. Following delivery, each dam received a control or 0.2% quercetin-containing control diet during lactation as follows: control on control (CC), control on restricted (LPC) and 0.2% quercetin-containing control on restricted (LPQ). At weaning (week 3), some of the pups from each dam were killed, and the remaining pups (CC, n= 8; LPC, n= 10; LPQ, n= 13) continued to receive a standard laboratory diet and were killed at week 23. Blood chemistry and phosphorylation levels of AMPKα, acetyl-CoA carboxylase (ACC), endothelial nitric oxide synthase (eNOS) and mammalian target of rapamycin (mTOR) in the livers of male offspring were examined. At week 3, the level of phosphorylated AMPK protein in LPQ increased about 1.5- and 2.1-fold compared with LPC and CC, respectively, and the level in LPQ at week 23 increased about 1.9- and 2.9-fold, respectively. A significant increase in phosphorylated ACC and eNOS levels was found in LPQ. There was no significant difference among the three groups in the level of phosphorylated mTOR protein. In conclusion, quercetin intake during lactation up-regulates AMPK activation in the adult offspring of protein-restricted dams and modulates the AMPK pathway in the liver. © 2013 Elsevier Inc. Source

Mukai Y.,Aomori University of Health and Welfare | Sato S.,Aomori University of Health and Welfare
Journal of Nutritional Biochemistry | Year: 2011

We investigated the effects of azuki bean (Vigna angularis) seed coats (ABSC), which contain polyphenols, on the vascular oxidative stress and inflammation associated with hypertension. Spontaneously hypertensive rats (SHR) and control normotensive Wistar-Kyoto (WKY) rats were divided into 2 groups each. One group was fed 0% ABSC; the other, a 1.0% ABSC-containing diet. Tail systolic blood pressure (SBP) was examined throughout ABSC treatment. At 8 weeks, vascular superoxide (O2 -) production was measured by lucigenin-enhanced chemiluminescence. mRNA expressions of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, macrophage chemoattractant protein-1 (MCP-1) and its receptor C-C chemokine receptor 2 (CCR2) in the aorta were analyzed by reverse transcriptase-polymerase chain reaction. Protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were determined by western blotting. Polyphenol-containing ABSC suppressed the elevation of SBP throughout the treatment period. The NADPH-stimulated O2 - level decreased significantly in the aorta of ABSC-treated SHR compared with the level of untreated SHR. The p47phox and Nox4 mRNA expression increased significantly in untreated SHR compared with that in WKY rats. Conversely, the level of p47phox mRNA was significantly lower in ABSC-treated SHR than in untreated SHR. The protein abundance of both iNOS and COX-2 was significantly decreased in the aorta of the ABSC-treated SHR compared with this abundance in untreated SHR. The MCP-1 and CCR2 mRNA expressions increased in untreated SHR, and these levels were significantly lower in ABSC-treated SHR. In conclusion, our results suggested that polyphenol-containing ABSC could attenuate vascular oxidative stress and inflammation during the progression of hypertension, and this may lead to an improvement in hypertension. © 2011 Elsevier Inc. Source

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