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Anyang, China

Xu Y.,Henan Eye Institute | Pang G.,Henan Eye Institute | Zhao D.,Henan Eye Institute | Gao C.,Henan Eye Institute | And 3 more authors.
Antimicrobial Agents and Chemotherapy

The in vitro activity of thimerosal versus those of amphotericin B and natamycin was assessed against 244 ocular fungal isolates. The activity of thimerosal against Fusarium spp., Aspergillus spp., and Alternaria alternata was 256 times, 512 times, and 128 times, respectively, greater than that of natamycin and 64 times, 32 times, and 32 times, respectively, greater than that of amphotericin B. Thimerosal's antifungal activity was significantly superior to those of amphotericin B and natamycin against ocular pathogenic fungi in vitro. Copyright © 2010, American Society for Microbiology. All Rights Reserved. Source

Han B.-H.,Anyang Eye Hospital
International Eye Science

AIM: To discuss the application of forced traction test in surgeries for orbital blowout fracture. METHODS: The clinical data of 28 patients with reconstructive surgeries for orbital fracture were retrospectively analyzed. All patients were treated with forced traction test before/in/after operation. The eyeball movement and diplopia were examined and recorded pre-operation, 3 and 6mo after operation, respectively. RESULTS: Diplopia was improved in all 28 cases with forced traction test. There was significant difference between preoperative and post-operative diplopia at 3 and 6mo (P<0.05). CONCLUSION: Forced traction test not only have a certain clinical significance in diagnosis of orbital blowout fracture, it is also an effective method in improving diplopia before/in/after operation. Source

Qu H.-M.,Anyang Eye Hospital | Li S.-T.,Anyang Eye Hospital
International Eye Science

AIM: To investigate the effects of photocoagulation with 577-nm laser combined with calcium dobesilate on diabetic retinopathy (DR). METHODS: From January 2012 to June 2012, 104 patients (180 eyes) with diabetic retinopathy were selected and randomly divided into medicine group, 577-nm laser group and combined treatment group. The medicine group consisting of 32 cases (56 eyes) received calcium dobesilate, and 577-nm laser group including 50 cases (86 eyes) were treated by photocoagulation with 577-nm laser. And 22 cases (38 eyes) of combined treatment group were treated with both methods above. The follow-up period was 6mo. The effects were evaluated by visual acuity and fundus fluorescein angiography (FFA). RESULTS: Compared with medicine group, the rate of disappeared retinal capillary nonperfusion areas and regressed neovascularization was higher in 577-nm laser group. And the visual acuity of 577-nm laser group was improved significantly more than the medicine group. The difference was statistically significant (P<0.05). The combined treatment group achieved more favorable results than every single treatment group (P<0.05). CONCLUSION: Photocoagulation with 577-nm laser combined with calcium dobesilate is effective for diabetic retinopathy and it is worth making more application in clinic. Copyright 2014 by the Press. Source

Li S.Y.,Capital Medical University | Li S.-M.,Capital Medical University | Zhou Y.H.,Capital Medical University | Liu L.R.,Anyang Eye Hospital | And 5 more authors.
Graefe's Archive for Clinical and Experimental Ophthalmology

Background: To prospectively observe the effects of undercorrection of myopia on myopia progression and axial elongation in a population of 12-year-old Chinese children. Methods: A total of 2,267 children in the Anyang Childhood Eye Study were examined at baseline, and 1,769 were followed for 1 year. Ocular examinations included cycloplegic autorefraction, axial length, visual acuity, vertometry, and accommodative lag. Questionnaires were completed by children and parents. Undercorrection of myopia was determined at baseline if presenting visual acuity could be improved by at least 2 lines with subjective refraction. Results: Of 253 myopic children with spectacles and available information, 120 (47.4 %) were undercorrected (−4.63D to −0.50D) and 133 (52.6 %) were fully corrected. In a multivariate model adjusting for age, gender, number of myopic parents, time spent on near work and outdoor activities per day, usage and time for wearing spectacles per day, children with undercorrection had significantly more baseline myopia (P < 0.01) and longer axial length (P = 0.03) than children with full correction. However, there were no significant differences in myopia progression (P = 0.46) and axial elongation (P = 0.96) at 1 year between the two groups of children. The regression analysis showed that myopia progression significantly decreased with increasing amount of undercorrection (r2 = 0.02, P = 0.02) in all children. Accommodative lag significantly decreased with increasing amounts of undercorrection (P < 0.01). Conclusions: Based on this 1-year study in Chinese children, undercorrection or full correction of myopia by wearing spectacles did not show any differences in myopia progression or axial elongation. © 2015, Springer-Verlag Berlin Heidelberg. Source

Li S.-M.,Capital Medical University | Li H.,Anyang Eye Hospital | Li S.-Y.,Capital Medical University | Liu L.-R.,Anyang Eye Hospital | And 7 more authors.
Investigative Ophthalmology and Visual Science

PURPOSE. To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS. A total of 1997 children aged 12.7 ± 0.5 (10.9–15.6) years in the Anyang Childhood Eye Study (ACES) were examined annually (baseline and two follow-up visits). Myopia was defined as cycloplegic SE < -0.50 diopters (D). Questionnaires were administered to the students and parents at baseline to gauge time spent outdoors and on other tasks. We ran mixed linear models including age, sex, and years of follow-up. RESULTS. In the full cohort of children there was a suggestive association between time spent outdoors and change in axial length; however, the effect size was very small (high versus low tertile: -0.016 mm/y, P = 0.053). The association was observed in children not myopic at baseline (high versus low tertile, -0.036 mm/y; P = 0.009) but not in those already myopic at baseline (high versus low tertile: -0.005 mm/y; P = 0.595). Time outdoors and change in SE showed similar, but nonsignificant, relationships (P > 0.05), perhaps due to insufficient statistical power. The other activities examined and parental myopia were not associated with changes in SE and axial length (P > 0.11). CONCLUSIONS. Within the normal range of variation encountered in these Chinese children, a wide range of activities were largely unrelated to myopia progression at this age. However, there was suggestive evidence that greater time outdoors was associated with slower axial elongation in nonmyopic teenagers, but not in existing myopes. © 2015 The Association for Research in Vision and Ophthalmology, Inc. Source

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