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Torrents-Rodas D.,Autonomous University of Barcelona | Fullana M.A.,Autonomous University of Barcelona | Fullana M.A.,Anxiety Unit | Fullana M.A.,Kings College | And 12 more authors.
Psychophysiology | Year: 2012

Few studies have investigated the role of the BDNF-val66met polymorphism in fear conditioning in humans, and previous results have been inconsistent. In the present study, we examined whether the BDNF-val66met was associated with differences in the acquisition and generalization of fear during a differential conditioning paradigm in a large sample of participants (N=141). Using three different indexes of fear learning (fear-potentiated startle, skin conductance response, and online risk ratings) no effects of the BDNF-val66met were found either on the acquisition or the generalization of conditioned fear. Taken together with previous data, our study suggests that the BDNF-val66met polymorphism has no effect on the acquisition or generalization of fear. © 2012 Society for Psychophysiological Research. Source


Torrents-Rodas D.,Autonomous University of Barcelona | Fullana M.A.,Autonomous University of Barcelona | Fullana M.A.,Anxiety Unit | Fullana M.A.,Kings College | And 6 more authors.
Psychophysiology | Year: 2014

We studied the temporal stability of individual differences in the acquisition and generalization of fear. Seventy-one participants were tested in two almost identical fear-acquisition and fear-generalization sessions (separated by 8 months). Acquisition and generalization were measured by the fear-potentiated startle, the skin conductance response, and online expectancies of the unconditioned stimulus. To control for the effects of previous experience, different stimuli were used for half of the participants in Session 2. Acquisition and generalization did not differ across sessions or as a function of the stimuli used in Session 2, and a significant proportion of individual differences in these processes was stable over time (generalizability coefficients ranged from 0.17 to 0.38). When the same stimuli were used, acquisition measures showed compromised stability. The results are discussed in terms of their theoretical and applied implications. © 2014 Society for Psychophysiological Research. Source


Fullana M.A.,Anxiety Unit | Fullana M.A.,Kings College London | Vilagut G.,Mental Health Services Research Unit IMIM Hospital del Mar | Vilagut G.,CIBER ISCIII | And 11 more authors.
Journal of Affective Disorders | Year: 2010

Background: The prevalence of obsessive-compulsive symptom dimensions and their sociodemographic and psychopathological correlates at the population level are unknown. Method: Obsessive-compulsive symptom dimensions and mental disorders were assessed with the Composite International Diagnostic Interview 3.0 in a random subsample (n = 2804) of individuals participating in a cross-sectional survey of the adult general population of six European countries. Results: The lifetime prevalence of any obsessive-compulsive symptom dimension was 13%. Harm/Checking was the most prevalent dimension (8%) followed by Somatic obsessions (5%) and Symmetry/Ordering (3%). Females were more likely to have symptoms in Contamination/Cleaning (OR = 3, 95%CI = 1.06-8.51) and Somatic obsessions (OR = 1.88, 95%CI = 1.05-3.37). All symptom dimensions were associated with an increased risk of most mental (but not physical) disorders. There were some differences in prevalence between countries. Limitations: The interference associated with each symptom dimension could not be assessed. Few direct data are available on the validity of the CIDI to assess obsessive-compulsive symptom dimensions. Conclusions: Obsessive-compulsive symptom dimensions are relatively frequent in the general population. Their sociodemographic and psychopathological correlates may be slightly different in clinical and community samples. They are associated with an increased risk of most mental disorders. © 2009 Elsevier B.V. All rights reserved. Source


Baeza-Velasco C.,Laboratory Dynamic of Human Abilities and Health Behaviors | Gely-Nargeot M.-C.,Laboratory Dynamic of Human Abilities and Health Behaviors | Pailhez G.,Anxiety Unit | Vilarrasa A.B.,Anxiety Unit
Current Sports Medicine Reports | Year: 2013

Joint hypermobility (JH) is a feature observed in several inherited conditions in which joints have a range of motion beyond normal limits. Such inherent flexibility makes it relatively easy for hypermobile people to perform certain physical activities, so this characteristic is particularly convenient for certain athletes. However JH also can carry some disadvantages: it has been associated to a higher risk of injury and to states of anxiety. The aim of this article is to provide an overview of the current evidence concerning the advantages and disadvantages of JH in the field of sport. We emphasize the importance of detecting JH in athletes in order to intervene appropriately through injury prevention programs, and emphasize how inherent anxiety may have a negative impact on sporting performance. © 2013 by the American College of Sports Medicine. Source


Pailhez G.,Anxiety Unit | Rosado S.,Anxiety Unit | Bulbena Cabre A.,Anxiety Unit | Bulbena A.,Anxiety Unit
Journal of Nervous and Mental Disease | Year: 2011

Our purpose was to evaluate joint hypermobility, an inherited disorder of the connective tissue significantly associated with anxiety disorders, in a sample of nonclinical students in relation to the frequency of severe fears and consumption of chocolate, coffee, cigarettes, and alcohol. One hundred fifty students completed the Hakim and Grahame Simple Questionnaire to detect hypermobility and the self-administered modified Wolpe Fear Scale (100 items). Severe fears and daily consumption of cigarettes, alcohol, coffee, and chocolate were compared with the hypermobility scores. We found significant differences when comparing severe fears between the groups with and without hypermobility (7.6 vs. 11; p = 0.001), reinforcing the hypothesis that the intensity of fears is greater in subjects with hypermobility. Only the frequency of chocolate intake was significantly higher among subjects with hypermobility (31.2% vs. 51.2%; p = 0.038) and may correspond to attempts of self-treatment of the collagen condition. © 2011 by Lippincott Williams & Wilkins. Source

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