Anurag Pharmacy College

andhra Pradesh, India

Anurag Pharmacy College

andhra Pradesh, India
SEARCH FILTERS
Time filter
Source Type

Nettem S.,Anurag Pharmacy College | Chinna Eswaraiah M.,Anurag Pharmacy College | Dipankar B.,Anurag Pharmacy College
International Journal of PharmTech Research | Year: 2013

Averrhoa carambola of family Oxalidaceae is commonly known as star fruit, carambola and in local name Kamrakh (hindi),Ambanamkaya (telugu). Various parts of tree has been used in traditional folkloric medicine. The present study was concentrated on the in-vitro antioxidant methods like DPPH free radical, nitric oxide radical, hydrogen peroxide radical scavenging and reducing power assays. The ethanolic extract of Averrhoa carambola stem was subjected to the above methods. The results of anti oxidant activity revealed that, the ethanolic extract shows good IC50 values. The results were compared with the standard ascorbic acid. The plant contains flavonoids, alkaloids, saponins and tannins. These active constituents alone or in combination may be responsible for the observed antioxidant activity.


Rahman H.,Assam University | Chinna Eswaraiah M.,Anurag Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The objective of present work is to study the in-vitro anti-oxidant activities of n-Hexane, Chloroform and Ethanol extract of Citrus macroptera (var annamensis) fruit peels so as to find out the extract having highest anti-oxidant activity. Methods: Anti-oxidant activity of the extracts were studied using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, Ferric reducing power activity, Hyderogen peroxide(H2O2) scavenging activity and Nitric Oxide(NO) scavenging activity. The total Phenolic contents and Flavanoid contents were estimated taking Gallic Acid and Quercetin calibration curve respectably. Results: In in-vitro anti-oxidant studies it was found that all the extracts posses anti-oxidant activities. The order of activities were ethanol> n-hexane> chloroform extracts of Citrus macroptera fruit peels. Ethanolic extract of Citrus macroptera fruit peels (EECM) in DPPH scavenging activity (IC50 281.11 μg/ml), Hydrogen Peroxide scavenging activity (IC50 216.49 μg/ml), Nitric Oxide scavenging activity (IC50 182.89 μg/ml) and were comparable with standard Ascorbic acid. The total Phenolic content was highest in EECM (142.5±3.29 mg/gm Eq of Gallic Acid) and Total Flavanoid content was highest in EECM (333.0±36.06 mg/gm Eq of Quercetin). Conclusion: Citrus macroptera fruit peels extracts possess anti-oxidant activities and the potency of anti-oxidant activities depends on the type of extract. The ethanol extract of Citrus macroptera fruit peels possess highest anti-oxidant activity in-vitro.


Chinna Eswaraiah M.,Anurag Pharmacy College | Nettem S.,Anurag Pharmacy College | Dipankar B.,Anurag Pharmacy College | Manasa N.,Anurag Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: Various parts of Averrhoa carambola of family Oxalidaceae is used in traditional folkloric medicine. The present study aimed to evaluate the protective effect of Averrhoa carambola stem ethanolic extract against CCl4 induced hepatic damage in rat. Averrhoa carambola stem ethanolic extract; ACSEE (250mg); ACSEE (500mg) were administered orally for 10 days in rats and compared with standard silymarin (100mg/kg) orally. Results: The results showed significant decrease in ALT, AST and ALP levels in Extract (ACSEE) treated groups which were increased due to CCl4 induced liver damage and are comparable with standard drug. Histopathological study of liver tissue reveals the hepatoprotective activity of Averrhoa carambola stem ethanolic extract. Conclusion: The Averrhoa carambola stem ethanolic extract posses hepatoprotective activity and further research work is under process for separation of components from Averrrhoa carambola stem ethanolic extract to understand the active phytoconstituents.


Eswaraiah M.C.,Anurag Pharmacy College | Satyanarayana T.,Andhra University
Journal of Pharmaceutical Research and Health Care | Year: 2010

Mussaenda erythrophylla (Rubiaceae) is native to western tropical Africa, occasionally seen in gardens and parks as ornamental plant in India. The Hepatoprotective activity of ethyl acetate and methanol extracts of M.erythrophylla (ME) Stem against carbon tetrachloride (CCl4) induced liver damage in Wistar albino rats. Ethyl acetate and methanolic extracts of ME (100,200mg/kg.p.o.), were administerd respectively, Silymarin (25 mg/kg.p.o.) was given as reference standard. The stem extracts were effective in protecting the liver against the injury induced by CCl 4 in animals. This was evident from significant reduction in serum enzyme, SGOT, SGPT, ALP and Total bilirubin (TB).Various pathological changes like centribular necrosis and vacuolization were observed in CCL4 treated rats, which were significant protective activity in groups treated with ME and silymarin. It was concluded from the study that ethyl acetate and methanolic extracts of ME possess hepatoprotective activity against CCl 4 induced hepatotoxicity in rats.


Siddartha Kumar P.,Balaji Institute of Pharmaceutical science | Junapudi S.,Anurag Pharmacy College | Gurrala S.,Gland institute of Pharmaceutical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

The conventional methodology was adopted to synthesize the titled compounds. The synthesis of titled compounds from starting compound i.e 2-amino-3-carboxamido-4,5,6,7 tetramethylene thiophene (SRP-2) was prepared from cyanoacetamide (SRP-1) by condensation with cyclohexanone in the presence elemental sulphur and a basic catalyst diethyl amine in ethanol to form (SRP-2). A set of thirteen azomethine derivatives (Schiff bases) were synthesized by reacting 2-amino-3-carboxamido-4,5,6,7-tetramethylene thiophene (SRP-2) in isopropyl alcohol with various substituted aromatic aldehydes involving glacial acetic acid as a catalyst. The title compounds (SRP-2a-m) were screened for their antibacterial activity against two Gram-positive bacteria i.e. Staphylococcus aureus & Bacillus subtilus and two Gram-negative bacteria i.e. Escherichia coli & Klebsiella pneumoniae using ampicillin as standard, each at a concentration of 50μg/0.1ml, adapting agar diffusion method. The compounds were also screened for their antifungal activity against two pathogenic fungi i.e. Candida albicans and Aspergillus niger using miconazole nitrate as standard at a concentration of 50μg/0.1ml, adapting agar diffusion method.


Rahman H.,Anurag Pharmacy College | Elumalai A.,Anurag Pharmacy College | Eswaraiah M.C.,Anurag Pharmacy College
Journal of Chemical and Pharmaceutical Research | Year: 2011

In the present study an attempt was made to evaluate the anxiolytic activity of ethanolic extract of Pisonia grandis R.Br leaves (EEPGL) in mice. The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board and Actophotometer behavior models. The efficacy of the extract (150 and 300 mg/kg, p. o) were compared with the standard drug Diazepam (2 mg/kg, p. o). EEPGL showed significantly increased the number of entries and time spent in the open arm in the elevated plus maze, increased the number of head dipping and line crossing in Hole board, decrease in locomotor in their respective Behavior Models. This study provides scientific basis of anxiolytic activity of Pisonia grandis R.Br.


Ravi P.,Anurag Pharmacy College | Elumalai A.,Anurag Pharmacy College | Chinna Eswaraiah M.,Anurag Pharmacy College | Kasarla R.,Anurag Pharmacy College
International Journal of Research in Ayurveda and Pharmacy | Year: 2012

Ocimum tenuiflorum is the most sacred herb in India and it is otherwise called as Krishna tulsi. O.tenuiflorum belongs to Lamiaceae family, which posses various healing medicinal properties for human life. Traditionally the various parts like leaves, flowers and stems are being used in the treatment various disorders such as skin diseases, cold, cough, fever, vomiting, swelling etc. Into this, O.tenuiflorum was reported to have anti-cancer, antimicrobial, antiseptic, antispasmodic, antifungal, antiviral, anti-inflammatory, analgesic and immuno-stimulatory properties. The main chemical constituents present in O.tenuiflorum are eugenol, methyl cinnamate, camphor and thymol. The aim of this work is to highlight the updated review consists of scientifically proved medicinal activities against various disorders.


The discovery of cyclooxygenase-2, expressed in response to inflammatory stimuli, present in the central nervous system, not in the gastric mucosa has provided a unique opportunity in the development of NSAIDs that lack the ulcerogenic effect. Thus it has led to the hypothesis that selective inhibitor of COX-2 over COX-1 may be better antiinflammatory agent with less adverse effects than the classical NSAIDs. As classical NSAIDs like aspirin, indomethacin are nonselective with respect two both isoforms. The preferential binding affinity of classical NSAIDs to COX-1 leads to mechanism based gastrointestinal, renal, hepatic side effects. Two varieties of acetophenones were condensed with three varieties of substituted benzaldehyde derivatives to get six chalcone derivatives which undergo condensation followed by cyclisation with isoniazid and 1-(2-napthyloxy acetate) hydrazine two get the final twelve 2-pyrazoline derivatives. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. The synthesized compounds were evaluated for their analgesic and anti-inflammatory activity. Two compounds which exhibited comparatively better analgesic and anti-inflammatory activity mong the synthesized derivatives were screened for their ulcerogenic potential and were found to be less ulcerogenic than the standard diclofenac sodium.


Satyanarayana T.,Anurag Pharmacy College | Eswaraiah M.C.,Andhra University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

Calycopteris floribunda Lam, (Combretaceae) a scandent woody shrub. The present study was concentrated on the in vitro antioxidant methods like superoxide radical, hydroxyl radical, lipid peroxidation and DPPH radical methods. The chloroform and methanol extracts of Calycopteris floribunda stem were subjected for the above methods. The results of antioxidant activity revealed that, the chloroform extract has lower IC50 values than the methanolic extract of Calycopteris floribunda. The lower IC50 value indicates the higher free radical scavenging ability. So, the chloroform extract has better antioxidant activity than methanolic extract. The results were compared with the standard ascorbic acid. The plant contains phytosterols, triterpenoids, alkaloids, saponins, flavonoids, glycosides and tannins. These active constituents alone or in combination may be responsible for the observed antioxidant activity.


Rahman H.,Anurag Pharmacy College | Manjula K.,Anurag Pharmacy College | Anoosha T.,Anurag Pharmacy College | Nagaveni K.,Anurag Pharmacy College | And 2 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The objective of present work is to study the In-vitro anti-oxidant activities of n-Hexane, Chloroform and Ethanol extract of Citrullus lanatus seeds to find out the extract having highest anti-oxidant activity. Material and Methods: The In-vitro anti-oxidant activity of the extracts were studied using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, Ferric reducing power activity, Hyderogen peroxide(H2O2) scavenging activity and Nitric Oxide(NO) scavenging activity. The total Phenolic contents and Flavanoid contents were estimated taking Gallic Acid and Quercetin calibration curve respectably. Results: In In-vitro anti-oxidant studies it was found that all the extracts posses In-vitro anti-oxidant activities. But the order of possessing activities were n-hexane>ethanol>chloroform extracts of Citrullus lanatus seeds. The total Phenolic content was highest in n-hexane extract and Total Flavanoid content was highest in ethanol extract. Conclusion: It can be concluded that Citrullus lanatusseed extracts possess anti-oxidant activities and the potency of anti-oxidant activities depends on the type of extract. The n-hexane extract of Citrullus lanatus seeds possess highest anti-oxidant activity in-vitro.

Loading Anurag Pharmacy College collaborators
Loading Anurag Pharmacy College collaborators