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Indore, India

The discovery of cyclooxygenase-2, expressed in response to inflammatory stimuli, present in the central nervous system, not in the gastric mucosa has provided a unique opportunity in the development of NSAIDs that lack the ulcerogenic effect. Thus it has led to the hypothesis that selective inhibitor of COX-2 over COX-1 may be better antiinflammatory agent with less adverse effects than the classical NSAIDs. As classical NSAIDs like aspirin, indomethacin are nonselective with respect two both isoforms. The preferential binding affinity of classical NSAIDs to COX-1 leads to mechanism based gastrointestinal, renal, hepatic side effects. Two varieties of acetophenones were condensed with three varieties of substituted benzaldehyde derivatives to get six chalcone derivatives which undergo condensation followed by cyclisation with isoniazid and 1-(2-napthyloxy acetate) hydrazine two get the final twelve 2-pyrazoline derivatives. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. The synthesized compounds were evaluated for their analgesic and anti-inflammatory activity. Two compounds which exhibited comparatively better analgesic and anti-inflammatory activity mong the synthesized derivatives were screened for their ulcerogenic potential and were found to be less ulcerogenic than the standard diclofenac sodium. Source

Satyanarayana T.,Anurag Pharmacy College | Eswaraiah M.C.,Andhra University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

Calycopteris floribunda Lam, (Combretaceae) a scandent woody shrub. The present study was concentrated on the in vitro antioxidant methods like superoxide radical, hydroxyl radical, lipid peroxidation and DPPH radical methods. The chloroform and methanol extracts of Calycopteris floribunda stem were subjected for the above methods. The results of antioxidant activity revealed that, the chloroform extract has lower IC50 values than the methanolic extract of Calycopteris floribunda. The lower IC50 value indicates the higher free radical scavenging ability. So, the chloroform extract has better antioxidant activity than methanolic extract. The results were compared with the standard ascorbic acid. The plant contains phytosterols, triterpenoids, alkaloids, saponins, flavonoids, glycosides and tannins. These active constituents alone or in combination may be responsible for the observed antioxidant activity. Source

Rahman H.,Assam University | Rahman H.,Anurag Pharmacy College | Eswaraiah M.C.,Anurag Pharmacy College | Anoosha T.,Anurag Pharmacy College | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2013

The present study aimed to evaluate the possible CNS activities of hexane extracts of Citrullus lanatus Seeds. The effect of hexane extracts of Citrullus lanatus Seeds was tested for Anti-depressant activity using Forced Swim Test (FST) and Tail Suspension Test (TST) in mice, Anxiolytic activity using Elevated Plus Maze(EPM) and Dark-light model in mice and effect on motor co-ordination and skeletal muscle using Rota-Rod, Grip Strength test in mice. The hexane extract exhibited significant anti-depressant and anxiolytic activities but the extract does not produces skeletal muscle relaxant activity beside it slightly improved the skeletal muscle activity in animal models. It can conclude that hexane extract of Citrullus lanatus Seeds possess anti-depressant and anxiolytic activity but does not affect on skeletal muscle activity. Finally, it can say that this can be used in CNS disorders like depression and anxiety and does not affect of skeletal muscle activity like synthetic drugs. ©RJPT All right reserved. Source

Elumalai A.,Anurag Pharmacy College | Chinna Eswaraiah M.,Anurag Pharmacy College | Rahman H.,Anurag Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2012

Pisonia grandis R.Br (Nyctaginaceae) is widely distributed throughout India and is a widespread evergreen tree commonly known as 'Leechai kottai keerai'. Leaves, stems and roots of this species are extensively used by the tribals in the preparation of several folk medicines. The plant is traditionally used as anti-rheumatic and antifungal. This plant is also pharmacologically studied for its anti-fungal, anti-oxidant, anti-microbial, anti-inflammatory, anti-diabetic, diuretic, analgesic and wound healing properties. Further studies reveal the presence of various phytochemical constituents mainly alkaloids, phenolic compounds and flavanoids. This will be helpful to create interest towards Pisonia grandis and may be useful in developing new formulations with more therapeutic and economical value. Source

Eswarudu M.M.,Anurag Pharmacy College | Chinna Eswaraiah M.,Anurag Pharmacy College | Prasanna Kumar K.,Anurag Pharmacy College | Sudhakar K.,Anurag Pharmacy College
Research Journal of Pharmacy and Technology | Year: 2012

Ultra Performance Liquid Chromatography (UPLC) is a relatively new technique giving new possibilities in liquid chromatography, especially concerning decrease of time and solvent consumption. UPLC chromatographic system is designed in a special way to withstand high system back-pressures. Special analytical columns UPLC BEH C18 packed with 1.7 μm particles are used in connection with this system. The quality control analyses of various pharmaceutical formulations are transferred from HPLC to UPLC system. The UPLC system allows shortening analysis time up to nine times and three times comparing to the conventional system using 5 μm and 3 μm particle packed analytical columns respectively. The negative effect of particle size decrease is back-pressure increase about nine times (versus 5 μm) or three times (versus 3 μm), respectively. The separation on UPLC is performed under very high pressures (up to 100 MPa) but it has no negative influence on analytical column or other components of chromatography system. Separation efficiency remains maintained or is even improved by UPLC. © RJPT All right reserved. Source

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