ANU Medical School

Canberra, Australia

ANU Medical School

Canberra, Australia
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Koerbin G.,University of Canberra | Koerbin G.,The Canberra Hospital | Potter J.M.,The Canberra Hospital | Abhayaratna W.P.,ANU Medical School | And 3 more authors.
Clinica Chimica Acta | Year: 2013

Objectives: To describe the distribution of hs-cTnI in a large cohort of healthy children. Design and methods: As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12. years. Samples were stored at - 80 °C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics. Results: More than 98% of the 12. year-old children had cTnI above the LoD of 1.0. ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian. Conclusions: In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution. © 2012 Elsevier B.V..


Chen T.,ANU Medical School | McDonald A.,National Capital Private Hospital | Shadbolt B.,ANU Medical School | Shadbolt B.,The Canberra Hospital | And 2 more authors.
Clinical and Investigative Medicine | Year: 2012

Introduction: In Non-Hodgkin Lymphoma (NHL), bone marrow histology is the gold standard against which ancillary investigations such as immunophenotyping and gene rearrangement studies are interpreted. There is currently no data on the reproducibility of histological findings. This study was conducted to determine the rates of inter- and intraobserver agreement in histological detection of bone marrow involvement in the two major subtypes of NHL, Diffuse Large B-cell Lymphoma (DLBCL), and Follicular Lymphoma (FL). Methods: The bone marrow slides of randomly selected DLBCL and FL cases were independently examined by two hematologists using standardized reporting criteria on two occasions at least two weeks apart. Samples included both aspirate and trephine biopsy slides. Weighted kappa statistics were used to examine agreement for the discrete measures. Results: Weighted kappa analyses showed variable inter-observer agreement in 38 DLBCL cases [aspirate=0.52; trephine= 0.77] and 38 FL cases [aspirate=0.48; trephine=0.77]. Conclusion: Overall, higher agreement rates were noted with trephine biopsies than with aspirates. Except for the high intra-observer agreement on trephine biopsy assessment in FL, there is poor agreement in histological staging of both FL and DLBCL which demonstrates the limitations of histological diagnosis and the futility of interpreting ancillary tests against histology. © 2012 CIM.

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