Newase K.M.,P.A. College |
Singh B.,Banasthali University |
Boltjes A.,Antonius Deusinglaan |
Domling A.,Antonius Deusinglaan
Tetrahedron Letters | Year: 2014
Azido-Ugi reaction involving cyclic ketone, primary amine, isonitrile, and azide afforded substituted tetrazole derivatives 5. These intermediates were hydrolyzed to corresponding acid derivatives. EDAC/HOBt mediated amide bond formation of 5 gave fused tetrazolo[1,5-a][1,4]benzodiazepine 6 in high yield and good diversity. © 2014 Elsevier Ltd. All rights reserved.