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West Point, PA, United States

Su D.-S.,Merck And Co. | Su D.-S.,Glaxosmithkline | Lim J.J.,Merck And Co. | Tinney E.,Merck And Co. | And 23 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2010

Biaryl ethers were recently reported as potent NNRTIs. Herein, we disclose a detailed effort to modify the previously reported compound 1. We have designed and synthesized a series of novel pyrazole derivatives as a surrogate for pyrazolopyridine motif that were potent inhibitors of HIV-1 RT with nanomolar intrinsic activity on the WT and key mutant enzymes and potent antiviral activity in infected cells. © 2010 Elsevier Ltd. All rights reserved.

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