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Unal B.,Antalya Research and Training Hospital | Karaveli F.S.,Akdeniz University | Pestereli H.E.,Akdeniz University | Erdogan G.,Akdeniz University
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: The two basic methods that are currently accepted to identify the HER2 status are immunohistochemistry and flyorescence in situ hybridization (FISH). The aim of this study was to perform the dual-color silver in situ hybridization (dc-SISH) technique as an alternative to FISH. Materials and Methods: A total of 40 invasive breast carcinoma cases were assessed for HER2 gene amplification by FISH and dualcolor SISH. Results: Significant correlation was found in the HER2 expression results obtained with the two approaches (p=0.001, p<0.05). The concordance rate was 92.3%. Conclusions: Foutine practical use of the dc-SISH method, which is much easier to apply, score, and evaluate, has many advantages. HER2 and CEN17 status can be evaluated simultaneously with the newly developed "Dual-Color Probe". All these specifications and the reliable results obtained support the widespread use of SISH technique in clinical practice.


Yilmaz F.,Numune Research and Training Hospital | Beydilli I.,Antalya Research and Training Hospital | Kavalci C.,Numune Research and Training Hospital | Yilmaz S.,Numune Research and Training Hospital
American Journal of Case Reports | Year: 2012

Background: Pregnancy can precipitate cardiac arrhythmias not previously present in seemingly well individuals. Atrial and ventricular premature beats are frequently present during pregnancy and are usually benign. Supraventricular tachycardia and malignant ventricular tachyarrhythmias occur less frequently. Maternal and fetal arrhythmias occurring during pregnancy may jeopardize the life of the mother and the fetus. Case Report: A 32-year-old pregnant women at 26 weeks gestation presented to the emergency department with palpitation. She had mild chest discomfort after a supraventricular tachycardia (SVT) episode but did not have syncope. After monitoring and access of an IV line, vagal manoeuvres were applied but the rhythm was resistant. Then she was treated with 5 mg metoprolol IV, but the SVT persisted. Then after IV infusion of adenosine triphosphate 6 to 12 mg, the rhythm was resistant. Synchronized cardioversion with 100 joules was performed. Patients' rhythm was normalized to a sinus rhythm. She was discharged from hospital without any adverse effects following 24-hour monitoring. Conclusions: All pregnant patients with SVT require careful maternal and fetal monitoring during treatment, and close collaboration between the managing obstetrician and the cardiologist is essential. © Am J Case Rep.


Greenage M.,Virginia Polytechnic Institute and State University | Kulaksizoglu B.,Antalya Research and Training Hospital | Cilingiroglu M.,NorthShore University Health System | Ali R.,Veterans Affairs Medical Center | And 2 more authors.
Current Atherosclerosis Reports | Year: 2011

Depression and anxiety are both known to be comorbid with coronary heart disease. Given the high prevalence of coronary heart disease today, specifically the aspect of hypertension, it seems more important than ever to investigate whether or not treatment of these comorbidities can have an effect on reducing hypertension. This article summarizes the limited amount of literature that has been published in this area and highlights what we believe to be a missing key element that will guide our own future research in this area. © Springer Science+Business Media, LLC 2010.


Firat A.,Kecioren Research and Training Hospital | Deveci A.,Ankara Numune Research and Training Hospital | Guler F.,Antalya Research and Training Hospital | Ocguder A.,Ataturk Research and Training Hospital | And 2 more authors.
Acta Orthopaedica et Traumatologica Turcica | Year: 2012

Objective: The aim of this study was to evaluate the long-term results of shoulder and elbow functions in humeral shaft fractures treated with functional brace, plate and screw osteosynthesis or intramedullary nailing. Methods: The study included 128 patients treated for humeral shaft fracture. The patients were divided into three groups according to treatment method: Group 1 (n=62) received functional brace, Group 2 (n=36) plate and screw osteosynthesis and Group 3 (n=30) intramedullary nailing. Coronal and sagittal humeral angulations were measured radiologically during the final follow-up. Shoulder and elbow functions were evaluated using the Constant shoulder score, the Mayo Elbow Performance Scoring and range of movement measurements. Results: The mean follow-up time was 74 (range: 20 to 132) months. Mean Constant shoulder scores were 92.4 in Group 1, 85.6 in Group 2 and 74 in Group 3. A statistically significant difference was detected between the Constant shoulder scores of Groups 2 and 3 (p<0.05). In the last follow-up, the mean Mayo Elbow Performance Score of Group 1 was 96.9, Group 2 was 95.7 and Group 3 was 89.2. Statistically significant differences were not detected between the Group 2 and 3 (p>0.05). In the statistical evaluation of the Constant shoulder scores, a statistically significant difference was detected between the Constant scores of patients with a varus angulation greater than 20° and those with neutral alignment. Conclusion: Functional results of humeral shaft fractures treated with functional brace appear to be satisfactory. Varus and antecurvatum may affect shoulder and elbow function. In the presence of surgical indications, plate and screw fixation technique is the most effective method in terms of shoulder and elbow functions. © 2012 Turkish Association of Orthopaedics and Traumatology.


Serinken M.,Pamukkale University | Eken C.,Akdeniz University | Gungor F.,Antalya Research and Training Hospital | Emet M.,Ataturk University | Al B.,University of Gaziantep
Academic Emergency Medicine | Year: 2016

Objective The objective was to compare intravenous morphine and intravenous acetaminophen (paracetamol) for pain treatment in patients presenting to the emergency department with sciatica. Methods Patients, between the ages of 21 and 65 years, suffering from pain in the sciatic nerve distribution and a positive straight leg-raise test composed the study population. Study patients were assigned to one of three intravenous interventions: morphine (0.1 mg/kg), acetaminophen (1 g), or placebo. Physicians, nurses, and patients were blinded to the study drug. Changes in pain intensity were measured at 15 and 30 minutes using a visual analog scale. Rescue drug (fentanyl) use and adverse effects were also recorded. Results Three-hundred patients were randomized. The median change in pain intensity between treatment arms at 30 minutes were as follows: morphine versus acetaminophen 25 mm (95% confidence interval [CI] = 20 to 29 mm), morphine versus placebo 41 mm (95% CI = 37 to 45 mm), and acetaminophen versus placebo 16 mm (95% CI = 12 to 20 mm). Eighty percent of the patients in the placebo group (95% CI = 63.0% to 99%), 18% of the patients in the acetaminophen group (95% CI = 10.7% to 28.5%), and 6% of those in the morphine group (95% CI = 2.0% to 13.2%) required a rescue drug. Adverse effects were similar between the morphine and acetaminophen groups. Conclusion Morphine and acetaminophen are both effective for treating sciatica at 30 minutes. However, morphine is superior to acetaminophen. © 2016 by the Society for Academic Emergency Medicine.

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