Antalya Egitim Ve Arastirma Hastanesi

Antalya, Turkey

Antalya Egitim Ve Arastirma Hastanesi

Antalya, Turkey
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Nur H.,Antalya Egitim Ve Arastirma Hastanesi | Toraman N.F.,Antalya Egitim Ve Arastirma Hastanesi
Turk Osteoporoz Dergisi | Year: 2011

Aim: The aim of this study was to investigate the impact of vertebral fractures on quality of life in postmenopausal osteoporosis. Material and Methods: 158 postmenopausal women were included in this study. Lumbar spine and proximal femur bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DEXA). Dorsal and lumbar lateral radiographs were taken to evaluate vertebral fractures. Anterior, middle and posterior segment heights were measured and the vertebra having 20 percent height loss compared to neighboring vertebra was accepted to be fractured. Quality of life was evaluated using the Quality of Life Questionnaire of the European Foundation of Osteoporosis (QUALEFFO). The patients were divided into three subgroups as osteopenia, osteoporosis without vertebral fracture and osteoporosis with vertebral fracture according to BMD and vertebral fracture status. Results: Age and duration of menopause of the group with vertebral fracture were significantly higher than the other groups (p<0.01). Lumbar spine, femoral neck and total t scores in the osteoporosis and osteoporosis with vertebral fracture groups were lower than those in the osteopenia group (p<0.01). In the assessment of quality of life, physical function, general health perception, mental function and total QUALEFFO scores in the group with vertebral fracture were significantly higher than those in the osteopenia group, while the general health perception and total QUALEFFO scores of the same group were significantly higher than those of the osteoporosis group without vertebral fracture (p<0.05). Conclusion: The quality of life of osteoporotic women with vertebral fracture was significantly lower than the osteoporotic women without vertebral fracture and osteopenic women, while there was no significant difference between osteoporotic and osteopenic groups. In postmenopausal osteoporotic women vertebral fractures have more adverse effects on quality of life rather than the changes in BMD.


Fidan N.,Celal Bayar University | Inci A.,Antalya Egitim Ve Arastirma Hastanesi | Coban M.,Antalya Egitim Ve Arastirma Hastanesi | Ulman C.,Celal Bayar University | Kursat S.,Celal Bayar University
Journal of Investigative Medicine | Year: 2016

The aim of the study was to evaluate the usefulness of serum bone turnover markers (BTM) and bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DEXA) in predialysis patients with chronic kidney disease (CKD). We enrolled 83 patients with CKD, 41 (49.4%) males, 42 (50.6%) females, with mean estimated glomerular filtration rate (eGFR) 23.90±12 (range=6.0-56.0). BMD of the lumbar spine (LS) (anteroposterior, L2 through L4), femoral neck (FN) and femoral trochanter (FT) were measured by DEXA. Biochemical BTM, including calcium (Ca), phosphorus (P), intact parathyroid hormone (PTH), serum specific alkaline phosphatase (serum AP), bone-specific AP (BSAP), plasma bicarbonate and 25-hydroxy-vitamin D (25hD) were used for the prediction of BMD loss. T score results of LS and FN were worse than FT. BMD levels were lower in females than in males (all p<0.05). According to different BMD T score levels, patients with age ≥65 years and patients in menopause were significantly more osteopenic ( p=0.026) and there was no relation between different BMD T scores and presence of diabetes ( p=0.654). A positive correlation was identified between the BMD of FN T-Z scores (r=0.270, p=0.029, r=0.306, p=0.012), FT T-Z scores (r=0.220, p=0.076, r:0.250, p=0.043) and serum HCO3, while the correlation with serum alkaline phosphatase (AP) and BSAP was considered to be negative. No statistically significant association was found between BMD of all the measured skeletal sites and eGFR. Loss of BMD was identified mostly in females over ≥65 years of age and after menopause. Higher serum levels of BSAP and AP can be determined in the advanced stages of renal failure and they reflect fracture risk of the femur, but not spine. Measurements of BMD by DEXA are useful to demonstrate bone loss, but not technical enough to distinguish the quantity of bone loss between different stages of CKD. © 2016 American Federation for Medical Research.


The aim of this study was to determine the seropositivity of Toxoplasma gondii in female patients admitted to the outpatient clinic of Antalya Training and Research Hospital, Department of Obstetrics and Gynecology. The seropositivity of Toxoplasma gondii was investigated with the "chemiluminescence immunoassay" method from August 2008 to May 2011. Toxoplasma seropositivity was 33.4% and the rate of seropositivity increased with age (p < 0.05). There has been a statistically significant gradual increase in Toxoplasma gondii IgM seropositivity between 2008 to 2011. Toxoplasmosis seropositivity in pregnant women is increasing in our area. In order to avoid congenital toxoplasmosis and the possible complications of pregnancy Toxoplasma gondii surveilans studies should be planned.


Bayar N.,Antalya Egitim ve Arastirma Hastanesi | Kucukseymen S.,Antalya Egitim ve Arastirma Hastanesi | Yuksel I.O.,Antalya Egitim ve Arastirma Hastanesi | Arslan S.,Antalya Egitim ve Arastirma Hastanesi
Turk Kardiyoloji Dernegi Arsivi | Year: 2013

Scorpion stings are usually benign, but especially cardiovascular death has been reported due to complications. Local reactions at the site of the sting as well as organ dysfunction may be due to the effects of a systemic toxin. As a result of the toxic effects of the scorpion toxin on the cardiovascular system, hypertension, arrhythmia, myocarditis, acute heart failure, and pulmonary edema may occur. In this report, we present a 49-year-old male patient who was admitted to our hospital with acute pulmonary edema and respiratory distress following scorpion sting at the wrist. In this case, detection of diffuse left ventricular systolic dysfunction on presentation, immediate improvement with medical treatment, and increased troponin levels in the absence of critical stenosis on coronary angiography suggest the diagnosis of acute myocarditis associated with scorpion bite. © 2013 Türk Kardiyoloji Derneǧi.


Celik T.,Antalya Egitim ve Arastirma Hastanesi | Celik U.,Antalya Egitim ve Arastirma Hastanesi
Cocuk Enfeksiyon Dergisi | Year: 2012

The disorder known as 'PANDAS syndrome' (paediatric autoimmune neuro-psychiatric disorders associated with Streptococci) consists of an abrupt onset of obsessive-compulsive symptoms and/or movement disorders, a pre-pubertal onset, and an episodic course. In this paper, the latest research findings on diagnosis and treatment in PANDAS were reviewed with a pediatric perspective. © 2012 by Pediatric Infectious Diseases Society.


Sahbaz A.,Bülent Ecevit University | Erol O.,Antalya Egitim ve Arastirma Hastanesi
Turk Jinekoloji ve Obstetrik Dernegi Dergisi | Year: 2014

Cervical cancer is the third most common gynecological cancer type in the world and approximately 500.000 women diagnosed as cervical cancer, annually. Human papilloma virus (HPV)-DNA presence was showed in about 95% of the cervical cancer cases. There are two types of over-the-counter HPV vaccine approved by Food and Drug Administration (FDA) named as bivalent and quadrivalent vaccine. World Health Organization (WHO), recommends HPV vaccination in order to prevent cervical cancer cases. Due to higher rates of HPV infection during the beginning of sexually active periods of life, vaccination is recommended prior to HPV infection. Most of the developed countries select individuals between 12-17 years of age as the target population in the national vaccination program. According to 2010 data, 33 countries in the world implemented national HPV vaccination program, however most of the countries where cervical cancer incidence is high do not have a vaccination program and policy.


Uygun V.,Antalya Egitim ve Arastirma Hastanesi | Kurtoglu E.,Antalya Egitim ve Arastirma Hastanesi
Hematology | Year: 2013

In thalassemia major (TM), without iron chelation therapy, iron-mediated free radical damage causes liver, endocrine, and myocardial toxicities. Deferoxamine has universally been the standard therapeutic option for iron chelation therapy; however, its usage is troublesome, leading to suboptimal patient compliance. In order to maximize the effectiveness of iron chelation therapy, oral iron chelators deferiprone and deferasirox constitute an important development, offering a potential to improve compliance. Although both oral drugs are effective, they have differences including different pharmacokinetics and side-effect profiles. Our retrospective evaluation of TM patients using oral chelators showed that oral chelators are effective in reducing iron overload regarding ferritin level and partially in cardiac T2* value. However, in our study side effects and discontinuation rates were unexpectedly high and close follow-up of TM patients using oral chelators should be carefully done. The variability in rate of side effects and drug discontinuation in spelenectomized patients using oral chelators suggests that spleen may have a role in pharmacokinetics of these drugs, as well. © W.S. Maney & Son Ltd 2013.


Infection with Toxoplasma gondii usually does not cause clinical symptoms in humans, but an acute infection during pregnancy can lead to congenital toxoplasmosis. Infection in early pregnancy may cause abortion, stillbirth or serious abnormalities of the fetus. In this study, determination of T. gondii seroprevalence among women of childbearing age who presented to our hospital's clinics is aimed. Toxoplasma IgM antibodies were investigated in 5013 sera and Toxoplasma IgG in 2986 sera of women between 15-49 years, in our hospital central laboratory, between 01 November 2008 and 31 August 2010. Eighty-nine (1.8%) seras were detected positive for Toxoplasma IgM and 968 (32.4%) for Toxoplasma IgG antibodies. It has been determined that 67.6% of women in the province of Antalya and its surroundings are susceptible to acute Toxoplasma infection during childbearing age and their babies are an at risk group for congenital toxoplasmosis.


PubMed | Akdeniz University, Antalya Egitim ve Arastirma Hastanesi and Antalya Training and Research Hospital
Type: Journal Article | Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research | Year: 2016

The relationship between soluble Klotho (s-Klotho) levels, fibroblast growth factor 23 (FGF23) levels, and albuminuria in patients with diabetic chronic kidney disease (CKD) remains unclear. A total of 109 patients with type 2 diabetes (mean age 61.639.77years), at the outpatient clinic of the Antalya Research and Training Hospital Nephrology Unit between January and June 2014, as well as 32 healthy controls (mean age 49.537.32years) were enrolled for this cross-sectional study. Patients were classified into three groups according to their urinary albumin creatinine ratio (UACR), normoalbuminuria (UACR<30mg/g), microalbuminuria (UACR 30-300mg/g), and macroalbuminuria (UACR>300mg/g). The blood was analyzed for FGF23, s-Klotho, parathyroid hormone (PTH), P, Ca, creatinine, and 25-hydroxyvitamin D3 (25hD) levels. Creatinine, s-Klotho, FGF23, and PTH levels were significantly higher and 25hD levels were significantly lower in the patient group than in the healthy controls (p<0.001). Between the groups according to UACR, 1-way analysis of variance revealed statistically significant differences for creatinine (p<0.001), 25hD (p<0.001), PTH (p=0.002), Ca (p=0.002), and albumin levels (p<0.001). A statistically significant positive correlation was found between s-Klotho and FGF23 (r=0.768; p=0.001), and between FGF23 levels and UACR (r=0.768; p=0.001). In conclusion, the results of the present study suggest that s-Klotho levels are significantly elevated in patients with diabetes and s-Klotho levels decreased with increasing albumin excretion in our patients despite a reduction in estimated glomerular filtration rate.


PubMed | Celal Bayar University and Antalya Egitim ve Arastirma Hastanesi
Type: Journal Article | Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research | Year: 2016

The aim of the study was to evaluate the usefulness of serum bone turnover markers (BTM) and bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DEXA) in predialysis patients with chronic kidney disease (CKD). We enrolled 83 patients with CKD, 41 (49.4%) males, 42 (50.6%) females, with mean estimated glomerular filtration rate (eGFR) 23.90 12 (range = 6.0-56.0). BMD of the lumbar spine (LS) (anteroposterior, L2 through L4), femoral neck (FN) and femoral trochanter (FT) were measured by DEXA. Biochemical BTM, including calcium (Ca), phosphorus (P), intact parathyroid hormone (PTH), serum specific alkaline phosphatase (serum AP), bone-specific AP (BSAP), plasma bicarbonate and 25-hydroxy-vitamin D (25hD) were used for the prediction of BMD loss. T score results of LS and FN were worse than FT. BMD levels were lower in females than in males (all p < 0.05). According to different BMD T score levels, patients with age 65 years and patients in menopause were significantly more osteopenic (p = 0.026) and there was no relation between different BMD T scores and presence of diabetes (p = 0.654). A positive correlation was identified between the BMD of FN T-Z scores (r = 0.270, p = 0.029, r = 0.306, p = 0.012), FT T-Z scores (r = 0.220, p = 0.076, r:0.250, p = 0.043) and serum HCO3, while the correlation with serum alkaline phosphatase (AP) and BSAP was considered to be negative. No statistically significant association was found between BMD of all the measured skeletal sites and eGFR. Loss of BMD was identified mostly in females over 65 years of age and after menopause. Higher serum levels of BSAP and AP can be determined in the advanced stages of renal failure and they reflect fracture risk of the femur, but not spine. Measurements of BMD by DEXA are useful to demonstrate bone loss, but not technical enough to distinguish the quantity of bone loss between different stages of CKD.

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