Wang J.C.,National Kaohsiung Normal University |
Wang Y.-C.,Chia Nan University of Pharmacy and Science |
Ko L.,Chia Nan University of Pharmacy and Science |
Wang J.H.,Antai Tian Sheng Memorial Hospital
Renewable and Sustainable Energy Reviews | Year: 2017
This study investigated the greenhouse gas emissions of amusement parks in Taiwan. The energy use of 26 parks evenly distributed throughout Taiwan was audited. An average of 583,000 people was found to visit each site annually. In addition, average annual energy consumption of 7699 MW h per site was observed, translating into 4096 t of carbon emissions per year. Every visitor generated an average of US$29.4 in revenue and 7.4 kg-CO2eq. The parks offering luxury services, such as 4-or 5-star accommodation and luxury food products, or many large-scale motorized water- or ground-based attractions consumed more energy than did ecology- and education-oriented parks. We categorized the parks into five categories, and found significant discrepancies among them in energy use. Two models for predicting annual carbon emissions and average carbon emissions per visit were developed, with the adjusted coefficient of determination being 0.934 and 0.792. This paper concludes by proposing several guidelines to assist park operators in reducing carbon emissions and improving energy efficiency. © 2017 Elsevier Ltd
Chen T.-H.,National Pingtung Institute of Commerce |
Chang H.-M.,Antai Tian Sheng Memorial Hospital |
Chang H.-M.,National Central University
International Journal of Advanced Manufacturing Technology | Year: 2010
This study deals with the emerging problem of jointly determining the optimal retail price, the replenishment cycle, and the number of shipments for exponentially deteriorating items under conditions of channel coordination, joint replenishment program, and pricing policy. In a one-manufacturer and multi-retailer channel setting, it is assumed that the retailers' demands are price-dependent and can be influenced by time. Two profit-maximization models including the non-integrated policy and the integrated policy were formulated with the aim of maximizing the channel-wide profit. In addition, this study demonstrated the optimal properties of the models, developed a search algorithm to obtain the optimal solutions, and offered structured and quantitative insights into the interplay between the proposed models through a numerical study. © 2009 Springer-Verlag London Limited.
Lin C.-H.,Antai Tian Sheng Memorial Hospital |
Ma H.,Taipei Veterans General Hospital
Journal of Plastic Surgery and Hand Surgery | Year: 2012
Pressure sore reconstruction is always a challenge for plastic surgeons due to its high recurrence rate. In addition to the myocutaneous flap, the perforator-based fasciocutaneous flap has become a new entity used for pressure sore reconstruction. This study presents a series of 26 perforator-based fasciocutaneous flaps for pressure sore reconstruction, with good outcomes in 21 patients from July 2008 to April 2011. The flaps were advanced, transposed, or rotated to obliterate the defects. Twenty of 26 flaps healed uneventfully without complication. One patient had a flap that totally necrosed, one had partial flap necrosis (flap rotated 180°in the above two cases), one had infection and healed by a secondary flap, one had minor wound dehiscence, one died of pneumonia 1 week postoperatively, and recurrence developed in one patient. The perforator-based fasciocutaneous flap is a reliable method and produced good results in this series. These flaps are well vascularised, have enough soft tissue bulk, and have a high degree of mobilisation freedom. © 2012 Informa Healthcare.
Cheng C.-C.,Antai Tian Sheng Memorial Hospital |
Ko J.-Y.,Chang Gung University
Chang Gung Medical Journal | Year: 2010
Background: Congenital dislocation of the knee (CDK) is a very rare condition that comprises a spectrum of deformities from subluxation to complete dislocation. The incidence of CDK is estimated at 1 per 100,000 live births, which is 1% of the incidence of developmental dysplasia of the hip (DDH). Moreover, 40-100% of patients with CDK have additional musculoskeletal anomalies, the most common being DDH and clubfoot. In general, the diagnosis is established immediately after birth according to the position of the knee recurvatum. Treatment with conservative methods at an early stage is most likely to yield successful results. We report here successful treatment of a series of CDK patients with early reduction. Methods: From July 1990 to June 2007, 19 patients with CDK (affecting 25 knees) were treated with early reduction. Of these, 6 knees had dislocation, and 19 had subluxation. Since 1990, treatment has been guided by a protocol that considers patient age and the severity of the condition. In patients examined within 24 hours of birth, early, direct reduction under gentle, persistent manual traction was attempted. Birth history and perinatal course were obtained from medical records. Associated musculoskeletal anomalies were observed and treated after reduction of the knee joint. A Pavlik harness was used for at least 4 months in the concomitant treatment of DDH and CDK. Knee function was graded as excellent, good, fair, or poor. Radiographs were used to assess DDH during follow-up. Results: After an average follow-up duration of 4.3 years, 18 patients showed an excellent or good outcome. One patient, whose knee could not be reduced, had severe multiple anomalies and died 16 days after birth. Fifteen of the nineteen patients had associated musculoskeletal anomalies, including DDH and foot deformity. Two cases of residual hip dysplasia after Pavlik harness application required an acetabular osteotomy. Conclusions: For CDK patients, early and direct closed reduction within 24 hours of birth affords outcomes graded as either excellent or good.
Li S.-J.,Sense Team Creativity Consulting Company |
Li S.-J.,National Sun Yat - sen University |
Huang Y.-Y.,Antai Tian Sheng Memorial Hospital |
Huang Y.-Y.,National Sun Yat - sen University |
Yang M.M.,University of New South Wales
Leadership in Health Services | Year: 2011
Purpose: The existence and form of interaction effects between service quality and satisfaction are still uncertain. The main purpose of this study is to examine whether satisfaction moderates the relationship between service quality and behavioral intentions. Design/methodology/approach: A structured questionnaire was distributed to the out-patients of 12 regional hospitals (the middle level) in Taiwan. Findings: The findings show that the forms of moderators played by satisfaction are not always the same under different dimensions of service quality (i.e. reliability, responsiveness, assurance, and empathy). Satisfaction positively moderates the influence of reliability/empathy on behavioral intentions, but negatively moderates the relationships between responsiveness/assurance and behavioral intentions. Originality/value: This study reveals the moderating role of satisfaction in the translation from service quality to behavioral intentions in health care services. Moreover, the natures of the moderating effects are not the same for different service quality dimensions. © Emerald Group Publishing Limited.
Tsai T.-C.,Antai Tian Sheng Memorial Hospital |
Huang H.-P.,Chung Shan Medical University |
Chang Y.-C.,Chung Shan Medical University |
Wang C.-J.,Chung Shan Medical University
Journal of Agricultural and Food Chemistry | Year: 2014
A previous study reported that anthocyanins from roselle (Hibiscus sabdariffa L.) showed significant anticancer activity in human promyelocytic leukemia cells. To explore the antitumor effect of anthocyanin, a roselle bioactive polyphenol in a rat model of chemical-induced leukemia was assayed. Anthocyanin extract of roselle (Hibiscus anthocyanins, HAs) was supplemented in the diet (0.1 and 0.2%). This study was carried out to evaluate the protective effect of HAs on N-nitrosomethylurea (NMU)-induced leukemia of rats. The study employed male Sprague-Dawley rats (n = 48), and leukemia was induced by intravenous injection of 35 mg kg-1 body weight of NMU dissolved in physiologic saline solution. The rats were divided into four groups (n = 12): control, NMU only, and HAs groups that received different doses of HAs (0.1 and 0.2%) daily, orally, after NMU injection. After 220 days, the animals were killed, and the following parameters were assessed: morphological observation, hematology examination, histopathological assessment, and biochemical assay. When compared with the NMU-only group, HAs significantly prevented loss of organ weight and ameliorated the impairment of morphology, hematology, and histopathology. Treatment with HAs caused reduction in the levels of AST, ALT, uric acid, and MPO. Also, the results showed that oral administration of HAs (0.2%) remarkably inhibited progression of NMU-induced leukemia by approximately 33.3% in rats. This is the first report to demonstrate that the sequential administration of HAs followed by NMU resulted in an antileukemic activity in vivo. © 2014 American Chemical Society.
Shiu C.-M.,Antai Tian Sheng Memorial Hospital |
Wang J.-J.,Chung Shan Medical University |
Yu F.-Y.,Chung Shan Medical University
Journal of the Science of Food and Agriculture | Year: 2010
Background: Maize contaminated with mycotoxin fumonisin B1 poses a global threat to agricultural production. In this study, polyclonal antibodies (pAb) specific to fumonisin B1 were generated from rabbits immunised with fumonisin B1-keyhole limpet haemocyanin (KLH). These antibodies were used to establish a sensitive competitive direct enzyme-linked immunosorbent assay (cdELISA) and gold nanoparticle immunochromatographic strip for detecting fumonisin B1 levels in maize-based foods and feeds. Results: In cdELISA, fumonisins B1, B2 and B3 at concentrations of 0.42, 0.58 and 81.5 ng mL-1 respectively caused 50% inhibition (IC50) of binding of fumonisin B1-horseradish peroxidase (HRP) to the antibodies. Effective on-site detection of fumonisin B1 was achieved by developing a rapid and sensitive pAb-based gold nanoparticle immunochromatographic strip. This strip had a detection limit of 5 ng mL-1 for fumonisin B1 in maize-based samples. Additionally, the whole analytical process could be completed within 10 min. Close examination of 15 maize-based samples by cdELISA revealed that 11 were fumonisin-positive, with a mean concentration of 435 ± 20.1 ng g-1. These results correlated well with those obtained by immunochromatographic strip.Conclusion: Both cdELISA and immunochromatographic strip methods established in this study are sensitive for rapid detection of fumonisins in agricultural commodities. © 2010 Society of Chemical Industry.
Tseng H.-H.,Antai Tian Sheng Memorial Hospital |
Chen P.-N.,Chung Shan Medical University |
Kuo W.-H.,Armed Force Taichung General Hospital |
Wang J.-W.,Chung Shan Medical University |
And 2 more authors.
Integrative Cancer Therapies | Year: 2012
Tumor metastasis is the most important cause of cancer death and various treatment strategies have targeted at preventing the occurrence of metastasis. Phyllanthus urinaria L is a popular folk medicine and has several proven biological properties, including antioxidant, antihypertension, and anti-inflammatory. This study provides molecular evidence associated with the antimetastatic effects of P urinaria L extracts (PUE), which contained polyphenols including gallic acid, methyl gallate, epicatechin, epigallocatechin-3-gallate, gallocatechin-3-gallate, rutin, epicatechin-3- gallate, and naringin, by showing a marked inhibition on the invasion (P <.001) and migration (P <.001) of highly metastatic A549 and Lewis lung carcinoma (LLC) cells. To further investigate the precise involvement of PUE in tumor metastasis, A549 and LLC cells were treated with PUE at various concentrations and results from zymography and Western blotting showed that a PUE treatment may decrease the expressions of matrix metalloproteinase-2 (MMP-2; P <.001), MMP-9 (P <.001), urokinase plasminogen activator (P <.001), and their endogenous inhibitors, that is, tissue inhibitor of metalloproteinase-2 and plasminogen activator inhibitor-1, in a concentration-dependent manner. Reverse transcription-polymerase chain reaction and MMP-2 promoter luciferase analysis (P <.001) revealed that PUE inhibits the transcription of MMP-2 mRNA. PUE also exerted an inhibitory effect on the DNA-binding activity and the nuclear translocation of NF-κB and AP-1. Furthermore, the inhibitory effects of PUE on the metastasis and growth of LLC cells in vivo were proven. These results indicate that PUE could be applied to be a potential antimetastatic agent. © The Author(s) 2012.
Huang Y.-Y.,Antai Tian Sheng Memorial Hospital |
Li S.-J.,Sense Team Creativity Consulting Company
Journal of Manufacturing Systems | Year: 2010
Taiwan is famous for its personal computer (PC) products, and this success demonstrates that Taiwanese manufacturers have effective strategies in managing supply chains of PC-related products. Among various strategies of supply chain management, achieving leagility is the main goal. The purpose of this study is to illustrate how a PC original equipment manufacturer (OEM) in Taiwan achieves leagility through reengineering its supply chain. The case study shows how the company adjusts its production processes from build-to-order (BTO) to configuration-to-order (CTO) to achieve leagility. Through this case study, some experiences of operating global logistics could be shared. © 2010 The Society of Manufacturing Engineers. Published by Elsevier Ltd. All rights reserved.
Huang Y.-Y.,Antai Tian Sheng Memorial Hospital |
Li S.-J.,National Sun Yat - sen University
Quality Management in Health Care | Year: 2010
The purpose of this study was to identify and evaluate service quality gaps among 3 roles (ie, hospital executives, frontline employees, and outpatients). A modified Chinese SERVQUAL scale was used to pinpoint dimension-specific quality gaps. A total of 1556 subjects (including 685 outpatients, 787 frontline employees, and 84 executives) were randomly selected from 12 middle-sized hospitals across Taiwan. Significant quality gaps among the 3 roles for 5 dimensions were found. Accordingly, strategies and tactics for improving service quality of hospitals are discussed. © 2010 Wolters Kluwer Health.