Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital

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Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital

Cooperation, United States
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Su C.-C.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Su C.-C.,Meiho University | Chen J.Y.-F.,Kaohsiung Medical University | Din Z.-H.,Meiho University | And 5 more authors.
Marine Drugs | Year: 2014

13-acetoxysarcocrassolide (13-AC), an active compound isolated from cultured Formosa soft coral Sarcophyton crassocaule, was found to possess anti-proliferative and apoptosis-inducing activities against AGS (human gastric adenocarcinoma cells) gastric carcinoma cells. The anti-tumor effects of 13-AC were determined by MTT assay, colony formation assessment, cell wound-healing assay, TUNEL/4,6-Diamidino-2-phenylindole (DAPI) staining, Annexin V-fluorescein isothiocyanate/propidium iodide (PI) staining and flow cytometry. 13-AC inhibited the growth and migration of gastric carcinoma cells in a dose-dependent manner and induced both early and late apoptosis as assessed by flow cytometer analysis. 13-AC-induced apoptosis was confirmed through observation of a change in Δψm, up-regulated expression levels of Bax and Bad proteins, down-regulated expression levels of Bcl-2, Bcl-xl and Mcl-1 proteins, and the activation of caspase-3, caspase-9, p38 and JNK. Furthermore, inhibition of p38 and JNK activity by pretreatment with SB03580 (a p38-specific inhibitor) and SP600125 (a JNK-specific inhibitor) led to rescue of the cell cytotoxicity of 13-AC-treated AGS cells, indicating that the p38 and the JNK pathways are also involved in the 13-AC-induced cell apoptosis. Together, these results suggest that 13-AC induces cell apoptosis against gastric cancer cells through triggering of the mitochondrial-dependent apoptotic pathway as well as activation of the p38 and JNK pathways. © 2014 by the authors; licensee MDPI, Basel, Switzerland.


PubMed | Tri Service General Hospital, Chang Gung Memorial Hospital Keelung Branch, Changhua Christian Hospital, Jen Ai Hospital Dali and 11 more.
Type: Journal Article | Journal: Journal of diabetes investigation | Year: 2016

The aim of the present study was to assess the glycemic control, adherence and treatment satisfaction in a real-world setting with basal insulin therapy in type 2 diabetes patients in Taiwan.This was a multicenter, prospective, observational registry. A total of 836 patients with type 2 diabetes taking oral antidiabetic drugs with glycated hemoglobin (HbA1c) >7% entered the study. Basal insulin was given for 24 weeks. All treatment choices and medical instructions were at the physicians discretion to reflect real-life practice.After 24-week treatment, 11.7% of patients reached set HbA1c goals without severe hypoglycemia (primary effectiveness end-point). HbA1c and fasting blood glucose were significantly decreased from (mean SD) 10.1 1.9% to 8.7 1.7% (-1.4 2.1%, P < 0.0001) and from 230.6 68.8 mg/dL to 159.1 55.6 mg/dL (-67.4 72.3 mg/dL, P < 0.0001), respectively. Patients received insulin therapy at a frequency of nearly one shot per day on average, whereas self-monitoring of blood glucose was carried out approximately four times a week. Hypoglycemia was reported by 11.4% of patients, and only 0.7% of patients experienced severe hypoglycemia. Slight changes in weight (0.7 2.4 kg) and a low incidence of adverse drug reactions (0.4%) were also noted. The score of 7-point treatment satisfaction rated by patients was significantly improved by 1.9 1.7 (P < 0.0001).Basal insulin therapy was associated with a decrease in HbA1c and fasting blood glucose, and an improved treatment satisfaction. Most patients complied with physicians instructions. The treatment was generally well tolerated by patients with type 2 diabetes, but findings pointed out the need to reinforce the early and appropriate uptitration to achieve treatment targets.


PubMed | Chang Gung University, Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital, Johns Hopkins University, National Kaohsiung University of Applied Sciences and 4 more.
Type: | Journal: Journal of hazardous materials | Year: 2016

Exposure to polycyclic aromatic hydrocarbons (PAHs) associated with ambient air particulate matter (PM) poses significant health concerns. Several modeling approaches have been developed for simulating ambient PAHs, but no hourly intra-urban spatial data are currently available. The aim of this study is to develop a new modeling strategy in simulating, on an hourly basis, grid-scale PM2.5-PAH levels. PM and PAHs were collected over a one-year time frame through an established air quality monitoring network within a metropolitan area of Taiwan. Multivariate linear regression models, in combination with correlation analysis and PAH source identification by principal component analysis (PCA), were performed to simulate hourly grid-scale PM2.5-PAH concentrations, taking criteria pollutants and meteorological variables selected as possible predictors. The simulated levels of 72-h personal exposure were found to be significantly (R=0.729**, p<0.01) correlated with those analyzed from portable personal monitors. A geographic information system (GIS) was used to visualize spatially distributed PM2.5-PAH concentrations of the modeling results. This new grid-scale modeling strategy, incorporating the output of simulated data by GIS, provides a useful and versatile tool in personal exposure analysis and in the health risk assessment of air pollution.


PubMed | Chang Gung University and Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital
Type: Journal Article | Journal: PloS one | Year: 2016

A certain proportion of hepatitis B virus (HBV)-infected patients with persistently normal alanine transaminase (ALT) levels have significant fibrosis. Using liver stiffness measurements (Fibroscan) and laboratory data, including serum ALT, quantitative HBsAg (qHBsAg), and HBV DNA, we attempted to predict the natural histories of these patients.Non-cirrhotic HBeAg-negative chronic hepatitis B patients with persistently normal ALT were followed up prospectively with the end points of HBsAg seroclearance and ALT elevation above the upper limit of normal. The factors that were predictive of the end points were identified.A total of 235 patients with an average age of 48.1 +/- 10.7 years were followed up for 7 years. Eight patients (3.4%) lost HBsAg, and 15 patients (6.4%) experienced ALT elevation. The overall cumulative HBsAg seroclearances were 0.4%, 1.3% and 2.3% at years 1, 3 and 5, respectively. Regarding HBsAg seroclearance, the qHBsAg (< 30 IU/ml) cutoff resulted in a hazard ratio (HR) of 19.6 with a 95% confidence interval (CI) of 2.2-166.7 (P = 0.008). The baseline ALT level (odd ratio (OR) 1.075, 95% CI 1.020-1.132, P = 0.006) and a qHBsAg above 1000 IU/ml (3.7, 1.1-12.4, P = 0.032) were associated with ALT elevation. Limited to men, the baseline liver stiffness (1.6, 1.0-2.5, P = 0.031) and a qHBsAg above 1000 IU/ml (10.4, 2.1-52.4, P = 0.004) were factors that were independently associated with ALT elevation.A low qHBsAg level predicted HBsAg clearance. Baseline ALT and a qHBsAg above 1000 IU/ml were independent predictive factors for ALT elevation. Among the men, the independent predictive factors for ALT elevation were qHBsAg and liver stiffness.


Wang H.,National Taiwan Ocean University | Wang H.,Hungkuang University | Li T.-L.,Academia Sinica, Taiwan | Hsia S.,Hungkuang University | And 3 more authors.
Oncotarget | Year: 2015

Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-α, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-α and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.


Su T.-R.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Lin J.-J.,National Pingtung University of Science and Technology | Tsai C.-C.,Kaohsiung District Agricultural Improvement Station | Huang T.-K.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | And 5 more authors.
International Journal of Molecular Sciences | Year: 2013

Gallic acid is one of the major flavonoids found in plants. It acts as an antioxidant, and seems to have anti-inflammatory, anti-viral, and anti-cancer properties. In this study, we investigated the effects of gallic acid on melanogenesis, including the activation of melanogenesis signaling pathways. Gallic acid significantly inhibited both melanin synthesis and tyrosinase activity in a dose- and time-dependent manner, and decreased the expression of melanogenesis-related proteins, such as microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP1), and dopachrome tautomerase (Dct). In addition, gallic acid also acts by phosphorylating and activating melanogenesis inhibitory proteins such as Akt and mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK). Using inhibitors against PI3K/Akt (LY294002) or MEK/ERK-specific (PD98059), the hypopigmentation effect was suppressed, and the gallic acid-initiated activation of MEK/ERK and PI3K/Akt was also revoked. Gallic acid also increased GSK3β and p-β-catenin expression but down-regulated p-GSK3β. Moreover, GSK3β-specific inhibitor (SB216763) restored gallic acid-induced melanin reduction. These results suggest that activation of the MEK/ERK, PI3K/Akt, and inhibition of Wnt/β-catenin signaling pathways is involved in the melanogenesis signaling cascade, and that activation by gallic acid reduces melanin synthesis via down-regulation of MITF and its downstream signaling pathway. In conclusion, gallic acid may be a potentially agent for the treatment of certain skin conditions. © 2013 by the authors; licensee MDPI, Basel, Switzerland.


Su C.-C.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Kao C.-T.,Chung Shan Medical University | Hung C.-J.,Chung Shan Medical University | Chen Y.-J.,Chung Shan Medical University | And 3 more authors.
Materials Science and Engineering C | Year: 2014

β-Tricalcium phosphate (β-TCP) is an osteoconductive material. For this research we have combined it with a low degradation calcium silicate (CS) to enhance its bioactive and osteostimulative properties. To check its effectiveness, a series of β-TCP/CS composites with different ratios were prepared to make new bioactive and biodegradable biocomposites for bone repair. Formation of bone-like apatite, the diametral tensile strength, and weight loss of composites were considered before and after immersion in simulated body fluid (SBF). In addition, we also examined the effects of fibroblast growth factor-2 (FGF-2) released from β-TCP/CS composites and in vitro human dental pulp cell (hDPC) and studied its behavior. The results showed that the apatite deposition ability of the β-TCP/CS composites was enhanced as the CS content was increased. For composites with more than 50% CS contents, the samples were completely covered by a dense bone-like apatite layer. At the end of the immersion point, weight losses of 19%, 24%, 33%, 42%, and 51% were observed for the composites containing 0%, 30%, 50%, 70% and 100% β-TCP cements, respectively. In vitro cell experiments show that the CS-rich composites promote human dental pulp cell (hDPC) proliferation and differentiation. However, when the CS quantity in the composite is less than 70%, the amount of cells and osteogenesis protein of hDPCs was stimulated by FGF-2 released from β-TCP/CS composites. The combination of FGF-2 in degradation of β-TCP and osteogenesis of CS gives a strong reason to believe that these calcium-based composite cements may prove to be promising bone repair materials.©2014 Published by Elsevier B.V.


Su T.-R.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Chang C.,Applied Information Sciences
Advances in Information Sciences and Service Sciences | Year: 2011

Evidence based patient choice seems based on a strong liberal individualist interpretation of patient autonomy; however, not all patients are in favor of such an interpretation. The purpose of this study was to investigate the cross-cultural difference in the dental preferred and perceived roles between Taiwan and UK. A cross-sectional survey, using the Control Preferences Scale designed to elicit decision-making preferences (H. Chapple, 2003), a set of five decisional roles cards were shuffled at the outset and presented in a random order by face-to-face interview. Patients were asked to state a preference between the two cards, depending on which role they ideally would like to play. Once the role preference hierarchy had been obtained, the patients were asked to pick one card and give a rationale for their perceived role after the dentist treatment. In addition, Unfolding theory provided a means of analyzing the data so that the degree of control preferred by each patient could be established. A convenience sample of 80 patients recruited from the University Hospital of Chungshan and a general dental clinic in Taiwan. Our study suggested that a majority of Taiwanese patients have positive preference in treatment decision making if they are fully informed. Physicians will give greater patient satisfaction if they respond to the desire of patients for participation in decision making. In summary, culture is the interrelationship of values, beliefs, behaviors, and transmitted from generation to generation. Patient participation encompasses several aspects that are not necessarily alike among different countries.


Chen K.-M.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Chiang M.-K.,National Chung Cheng University | Wang M.,Chung Shan Medical University | Ho H.-C.,Tzu Chi University | And 2 more authors.
Microbial Pathogenesis | Year: 2014

Background: Klebsiella pneumoniae has emerged as one of the major pathogens for community-acquired and nosocomial infections. A four-gene locus that had a high degree similarity with Escherichia coli pgaABCD and Yersinia pestis hmsHFRS was identified in K.pneumoniae genomes. The pgaABCD in E.coli encodes the envelope-spanning Pga machinery for the synthesis and secretion of poly-β-linked N-acetylglucosamine (PNAG). In a limited number of phylogenetically diverse bacteria, PNAG was demonstrated to mediate biofilm formation and had a role in the host-bacteria interactions. The presence of conserved pgaABCD locus among various K.pneumoniae strains suggested a putative requirement of PNAG for this bacterium. Results: In this study, an in-frame deletion of pgaC was generated in K.pneumoniae CG43 and named δ. pgaC. The loss of pgaC affected the production of PNAG and attenuated the enhancement of invitro biofilm formation upon the addition of bile salts mixture. In mouse models, δ. pgaC exhibited a weakened ability to colonize the intestine, to disseminate extraintestinally, and to induce a systemic infection when compared to K.pneumoniae CG43. Conclusions: Our study demonstrated that pgaC participated in the bile salts induced biofilm formation and was required for K.pneumoniae virulence invivo. © 2014 Elsevier Ltd.


Lin C.-H.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital | Hsu C.-W.,Tungs Taichung MetroHarbor Hospital | Tsao T.-Y.,Tungs Taichung MetroHarbor Hospital | Chou J.,Cheng Hsin General Hospital
Diagnostic Pathology | Year: 2012

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease. The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM. In the present report, we describe the first case of IGM associated with risperidone-induced hyperprolactinemia.Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8120093785928228. © 2012 Lin et al; licensee BioMed Central Ltd.

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