Su T.-R.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital |
Chang C.,Applied Information Sciences
Advances in Information Sciences and Service Sciences | Year: 2011
Evidence based patient choice seems based on a strong liberal individualist interpretation of patient autonomy; however, not all patients are in favor of such an interpretation. The purpose of this study was to investigate the cross-cultural difference in the dental preferred and perceived roles between Taiwan and UK. A cross-sectional survey, using the Control Preferences Scale designed to elicit decision-making preferences (H. Chapple, 2003), a set of five decisional roles cards were shuffled at the outset and presented in a random order by face-to-face interview. Patients were asked to state a preference between the two cards, depending on which role they ideally would like to play. Once the role preference hierarchy had been obtained, the patients were asked to pick one card and give a rationale for their perceived role after the dentist treatment. In addition, Unfolding theory provided a means of analyzing the data so that the degree of control preferred by each patient could be established. A convenience sample of 80 patients recruited from the University Hospital of Chungshan and a general dental clinic in Taiwan. Our study suggested that a majority of Taiwanese patients have positive preference in treatment decision making if they are fully informed. Physicians will give greater patient satisfaction if they respond to the desire of patients for participation in decision making. In summary, culture is the interrelationship of values, beliefs, behaviors, and transmitted from generation to generation. Patient participation encompasses several aspects that are not necessarily alike among different countries.
Su C.-C.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital |
Kao C.-T.,Chung Shan Medical University |
Hung C.-J.,Chung Shan Medical University |
Chen Y.-J.,Chung Shan Medical University |
And 2 more authors.
Materials Science and Engineering C | Year: 2014
β-Tricalcium phosphate (β-TCP) is an osteoconductive material. For this research we have combined it with a low degradation calcium silicate (CS) to enhance its bioactive and osteostimulative properties. To check its effectiveness, a series of β-TCP/CS composites with different ratios were prepared to make new bioactive and biodegradable biocomposites for bone repair. Formation of bone-like apatite, the diametral tensile strength, and weight loss of composites were considered before and after immersion in simulated body fluid (SBF). In addition, we also examined the effects of fibroblast growth factor-2 (FGF-2) released from β-TCP/CS composites and in vitro human dental pulp cell (hDPC) and studied its behavior. The results showed that the apatite deposition ability of the β-TCP/CS composites was enhanced as the CS content was increased. For composites with more than 50% CS contents, the samples were completely covered by a dense bone-like apatite layer. At the end of the immersion point, weight losses of 19%, 24%, 33%, 42%, and 51% were observed for the composites containing 0%, 30%, 50%, 70% and 100% β-TCP cements, respectively. In vitro cell experiments show that the CS-rich composites promote human dental pulp cell (hDPC) proliferation and differentiation. However, when the CS quantity in the composite is less than 70%, the amount of cells and osteogenesis protein of hDPCs was stimulated by FGF-2 released from β-TCP/CS composites. The combination of FGF-2 in degradation of β-TCP and osteogenesis of CS gives a strong reason to believe that these calcium-based composite cements may prove to be promising bone repair materials.©2014 Published by Elsevier B.V.
Liu C.-H.,Kaohsiung Chang Gung Memorial Hospital |
Chang W.-J.,Kaohsiung Chang Gung Memorial Hospital |
Chin C.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital
International Journal of Gerontology | Year: 2015
Proteus species is a common cause of urinary tract and wound infections in humans. We herein present the case of a 71-year-old male who had fever, a new-onset heart murmur, bacteremia, and a vegetation over his native aortic valve in echocardiography. This rare case demonstrated that infective endocarditis could be caused by Proteus mirabilis from an infected pressure ulcer. © 2015, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.
Chen K.-M.,Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital |
Chiang M.-K.,National Chung Cheng University |
Wang M.,Chung Shan Medical University |
Ho H.-C.,Tzu Chi University |
And 2 more authors.
Microbial Pathogenesis | Year: 2014
Background: Klebsiella pneumoniae has emerged as one of the major pathogens for community-acquired and nosocomial infections. A four-gene locus that had a high degree similarity with Escherichia coli pgaABCD and Yersinia pestis hmsHFRS was identified in K.pneumoniae genomes. The pgaABCD in E.coli encodes the envelope-spanning Pga machinery for the synthesis and secretion of poly-β-linked N-acetylglucosamine (PNAG). In a limited number of phylogenetically diverse bacteria, PNAG was demonstrated to mediate biofilm formation and had a role in the host-bacteria interactions. The presence of conserved pgaABCD locus among various K.pneumoniae strains suggested a putative requirement of PNAG for this bacterium. Results: In this study, an in-frame deletion of pgaC was generated in K.pneumoniae CG43 and named δ. pgaC. The loss of pgaC affected the production of PNAG and attenuated the enhancement of invitro biofilm formation upon the addition of bile salts mixture. In mouse models, δ. pgaC exhibited a weakened ability to colonize the intestine, to disseminate extraintestinally, and to induce a systemic infection when compared to K.pneumoniae CG43. Conclusions: Our study demonstrated that pgaC participated in the bile salts induced biofilm formation and was required for K.pneumoniae virulence invivo. © 2014 Elsevier Ltd.
Wang H.,National Taiwan Ocean University |
Wang H.,Hungkuang University |
Li T.-L.,Academia Sinica, Taiwan |
Hsia S.,Hungkuang University |
And 3 more authors.
Oncotarget | Year: 2015
Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-α, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-α and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.