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Toussirot E.,French Institute of Health and Medical Research | Toussirot E.,Besancon University Hospital Center | Toussirot E.,University of Franche Comte | Toussirot E.,ANR Inc | And 4 more authors.
Frontiers in Immunology | Year: 2014

Psoriasis (Pso) is a common chronic cutaneous inflammatory disease involving the skin that is associated with serious comorbidities. Comorbidities in Pso include psoriatic arthritis (Ps A), reduced quality of life, malignancy, depression, but also a constellation of associated conditions that enhance the cardiovascular (CV) risk. Indeed, obesity is common in patients with Pso or Ps A and is considered to be a risk factor for the onset of these diseases. Patients with Pso and Ps A share common obesity-related complications such as metabolic syndrome (Met S), dyslipidemia, diabetes or insulin resistance, and CV diseases. Chronic inflammation in Pso and Ps A partially explains the development of atherosclerosis and CV diseases. In parallel, body composition is disturbed in patients with Pso or Ps A, as suggested by anthropometric measurements, while an excess of abdominal adiposity is observed in Ps A, enhancing the risk of Met S and CV diseases. Adipokines may link the adipose tissue to the obesity-related complications of Pso and Ps A. Indeed, altered circulating levels of the adipokines leptin, adiponectin, visfatine, and resistin have been found in patients with Pso or Ps A. In addition, an excess of adipose tissue may compromise the therapeutic response to traditional drugs or biological agents in Pso and Ps A.This paper reviews the comorbidities that contribute to enhanced CV risk, the body composition results, and the potential role of adipokines in systemic inflammation and energetic balance in Pso and Ps A. © 2014 Toussirot, Aubin and Dumoulin.


Toussirot E.,French Institute of Health and Medical Research | Toussirot E.,Besancon University Hospital Center | Toussirot E.,University of Franche Comte | Toussirot E.,ANR Inc
Expert Opinion on Drug Safety | Year: 2015

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease that is associated with increased cardiovascular (CV) morbidity and mortality. This increased CV burden is the result of an enhanced prevalence of traditional CV risk factors, the effects of treatments given for RA but also systemic inflammation. In this setting, the control of inflammation by the current therapeutic approach may improve the overall CV prognosis of RA.Areas covered: This paper analyses the impact of TNFα inhibitors on the different CV risk factors with a special emphasis on lipid profile and body composition. The lipid profile under TNFα inhibitors changes, an increase in total and high density lipoprotein (HDL) cholesterol is observed but the atherogenic index and low density lioprotein cholesterol are unaffected. In parallel, TNFα inhibitors induce an accumulation of fat in the abdominal/visceral region. Analysis of cohort and registry studies indicates that CV events are reduced under this treatment.Expert opinion: Overall, the favourable CV effect under TNFα inhibitors does not seem to be explained by the changes in traditional CV risk factors, but rather by the improvement in systemic inflammation. Alternatively, the changes in body composition raise the question of their effect on long-term CV safety. © 2015 Informa UK, Ltd.


KINGSPORT, Tenn., Nov. 29, 2016 /PRNewswire/ -- Alpha Natural Resources Holdings, Inc. and ANR, Inc. announce that an agreement has been reached to resolve the concerns expressed by the West Virginia Department of Environmental Protection over various unaccounted-for expenses, which were...


KINGSPORT, Tenn., Feb. 22, 2017 /PRNewswire/ -- Alpha Natural Resources Holdings, Inc. and ANR, Inc. announce outstanding safety performance for 2016, with five affiliate operations in West Virginia honored for safety achievements by the West Virginia Office of Miners' Health Safety...


News Article | September 6, 2015
Site: www.agence-nationale-recherche.fr

In an era when producing sustainably is paramount, critical resources are undergoing rapid supply-side changes. The ASTER project (Systemic Analysis of Rare Earth Elements) has looked into some of today's most pressing challenges, including dependence (rare earths are actually abundant, though highly spread out), societal challenges posed by their extraction and the upheaval of production relationships. The project, which benefited from French National Research Agency (ANR) funding, also addressed how to recycle and make the best and most responsible use of natural resources. The ASTER project set out to map the flows and stocks of rare earths as well as the 14 chemically related precious metals and semi-metals used in certain green technologies, including motors and permanent magnets which respectively power electric vehicles and wind turbines. ASTER achieved a more thorough understanding of stocks and flows in Europe, identifying recycling opportunities and gauging the strategic value of individual rare earths in a market subjected to great strain over recent years. ASTER has provided researchers with crucial geopolitical insight. China, which puts out monopoly-level production (85-95%) of rare earth metals, has recently enacted export limitations. This imposed or artificial shortage comes on top of other factors influencing the strategic value of a given rare earth. Terbium, for example, despite its being spread out geographically, is experiencing decreasing demand and rising recycling potential, countering supply shortages.  As for other rare earths whose supply needs are unable to be met through product recycling, solutions must be implemented such as "responsible" mines (mining operations seeking to actively minimise related environmental risks) or mine tailings recovery processing. The project also provided a glimpse of the role that Europe could play in rare earth production based on European industrial groups’ know-how and the worldwide dimensions of the rare earth value chain from exploration to use. ASTER has shown that France and the European Union need to support and invest in the energy transition and related technologies to forecast and control fluctuations and secure jobs in its historical metallurgical sector over the long run. This holistic approach, combining the prospecting of Europe's subsurface and reusing end-of-life products, has the power to guarantee Europeans a more effective provisioning of resources whilst preserving the environment. Such a project by its very nature bears upon industrial and public interest issues at national and European levels. ASTER, which ran from January 2012 to June 2015 under the ANR "Ecotech" programme (Sustainable production and environmental technologies), was allocated an ANR grant worth €558 k. The project was led by the chemical group Solvay, the firm BIO by Deloitte, the French geological survey (BRGM), Université Paul-Sabatier in Toulouse and the Polytechnic Institute of Lasalle Beauvais. These organisations boast expertise covering disciplines including sub-soil resource management, chemical manufacturing and sustainable development. Teams from the European EURARE project (European RARe Earth) coordinated by the British Geological Survey also worked together with the ASTER team.


For the fourth consecutive year, ANR is joining NSF and NIH to issue a call for collaborative projects in computational neuroscience. The BMBF in Germany and the United States-Israel Binational Science Foundation (BSF) are also participating in the initiative. The call is launched under the NSF “Collaborative Research in Computational Neuroscience” CRCNS programme. The deadline for applications is 29 October 2015. Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines. Through the CRCNS programme, the French National Research Agency (ANR) is joining  the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (BMBF), and the United States-Israel Binational Science Foundation (BSF) to support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system. Two types of proposals will be considered: research proposals describing collaborative research projects, and data sharing proposals to enable sharing of data and other resources. Only transnational projects will be considered by ANR: project consortia must include at least one French partner and one US partner. Consortia involving French, American, Israeli and/or German partners will also be considered. NSF will coordinate and manage the review of proposals jointly with ANR and other participating funding organisations, through a joint panel review process used by all participating funders. Each agency will fund its national teams according to its own national rules. The deadline to submit applications to NSF is 29 October 2015.


News Article | September 6, 2015
Site: www.agence-nationale-recherche.fr

Since 2005, ANR has never stopped evolving and reinventing itself to better serve the scientific communities, both academic and industrial. This year has been one of transformation and consolidation; it will go down in the books as a milestone year for ANR. In 2014, the agency seized the opportunity to carry out an in-depth organisational overhaul, formally introduce a new two-stage selection process as well as create new funding instruments to support a wide array of research in a number of scientific disciplines and themes. With its 10-year anniversary drawing near, ANR was entrusted with new missions by the French government, further cementing the agency's position in the European and international ecosystem.  ANR chairs two European Joint Programming Initiatives (JPI), is hosting the Belmont forum's world secretariat promoting inter-agency action on climate change, and has asserted itself as an outward-looking organisation, a driving force in the European Research Area and a player in scientific policy discussions on the world stage. Looking back on last year's achievements, Annual Report 2014 shines a light on the role and activities of ANR in all their diversity. It places international activities front and centre and provides an overview of successful scientific endeavours supported by the agency, showcasing the value of project-based funding.


News Article | September 6, 2015
Site: www.agence-nationale-recherche.fr

On 18 June 2015, the ANR Governing Board adopted Work Programme 2016, a text outlining ANR's actions and calls for proposals for the 2016 budget exercise. Work Programme 2016 is the agency roadmap for the year to come; it presents the research priorities for 2016 as well as the funding instruments offered to researchers. The Work Programme is intended for the scientific communities, for academia and industry alike (especially SMEs and intermediate-sized companies). ANR's Work Programme falls within the scope of "France Europe 2020", the Strategic Agenda for Research, Technology Transfer and Innovation and the National Strategic Agenda (SNR). As it drafts its Work Programme, ANR canvases the national thematic Alliances and the CNRS for proposals. The agency also consults with Scientific Challenge Steering Committees for feedback concerning the previous year's campaign. In this sense, the Work Programme was prepared in coordination with the French Research Ministry. Work Programme 2016 is divided into four cross-cutting components, each endowed with its own budget. Each component also has its own separate funding instruments, calls for proposals, and distinct programmes: Holding a generic call for proposals allows for the mutualising of a large number of each component’s actions. A description of the generic call can be found in the document detailing submission procedures and selection processes. Specific calls for proposals are also launched alongside the generic call. These correspond to specific research instruments (OH Risk, LabCom, Industrial Chairs, Carnot, Hosting High-Level Researchers, MRSEI, Astrid, etc.), or to specific European and international calls (bilateral and multilateral calls, calls launched under the ERA-NETs and JPIs). Each call for proposals will be launched with its own call text and a dedicated calendar (Follow along on ANR's website and Twitter page). The generic call for proposals was opened on 24 July 2015. The deadline for submitting pre-proposals (Collaborative Research Projects - PRC, Collaborative Research Projects involving Enterprises - PRCE and Young Researchers - JCJC) is 13 October 2015 at 1 p.m. (Paris local time). To facilitate international collaboration, ANR has concluded bilateral agreements with its sister agencies. Projects grouped under this heading (International Collaborative Research Projects - PRCI) are part of the generic call for proposals but follow their own specific submission calendars. The countries concerned by these agreements are (to be confirmed): Germany, Austria, Brazil (States of Pernambuco and Sao Paulo), Canada, China, India, Hong Kong, Singapore, Switzerland, Taiwan and Turkey. The definitive list of agreements established by ANR for this call for proposals will be posted on the ANR website no later than 15 September 2015. All related annexes will also be available by this date at the latest. Project coordinators interested in applying to a PRCI must also register their projects by 13 October 2015. Applicants may also submit projects outside the scope of bilateral agreements with one or several foreign teams from any country.  Such projects are subject to the generic call for proposals process.


News Article | February 23, 2017
Site: www.prnewswire.com

KINGSPORT, Tenn., Feb. 23, 2017 /PRNewswire/ -- Alpha Natural Resources Holdings, Inc. and ANR, Inc., announce the divestment of substantially all of their affiliated mining assets in Harlan County, Kentucky, to JRL Coal LLC of Marietta, Georgia. The Coalgood assets include a perm...

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