Annai Veilankannis Pharmacy College

Saidapet, India

Annai Veilankannis Pharmacy College

Saidapet, India
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Rengarajan S.,Annai Veilankannis Pharmacy College | Rani M.,Annai Veilankannis Pharmacy College
Iranian Journal of Pharmacology and Therapeutics | Year: 2012

Peptic ulcer is one of the most prevalent gastrointestinal disorder, commonly occurs in developed countries. The present work was carried out to evaluate antiulcer effect of Ipomoea batatas (L) dietary tuberous roots. The Ethanolic extract of Ipomoea batatas (EEIB) was prepared by dynamic maceration for 7 days at room temperature using 70% ethanol (V/V). The antiulcer activity was evaluated by the Pylorus Ligation (PL) and cold restraint stress (CRS) Induced Ulcer models. Male Wister rats were divided into four groups of 3 animals each for both models and received Normal saline10ml/kg, Famotidine 20 mg/kg, EEIB at 250 & 500 mg/kg respectively. After 1 h of Standard and test treatments pyloric ligation was performed and gastric pH, total acidity, free acidity, total protein, pepsin, ulcer score and ulcer index were determined. In CRS model, drugs were administered orally 30 min prior to subjecting the animals to cold stress (2°C for 3 hours), then ulcer score and ulcer index were determined. Results were mean ± SEM (n=3) and analysed using one way ANOVA followed by Dunnett test. p < 0.05 was considered significant when compared with the toxicant groups. In PL model EEIB significantly (p < 0.01) reduced the ulcer index by 55.24% and 61.45% at 250 & 500 mg/kg doses respectively. In CRS model, both the doses of EEIB significantly (p < 0.01) reduced ulcer index by 51.35% (250 mg/kg) and 75.68% (500 mg/kg). The Ipomoea batatas roots possess anti ulcer activity as evidenced by its significant inhibitory effects on PL and CRS induced ulcers. © 2012 by Tehran University of Medical Sciences (TUMS).


Sravani Shilpa K.,Annai Veilankannis Pharmacy College | Kumar M.A.,Annai Veilankannis Pharmacy College | Senthil Kumar M.,P.A. College
International Journal of Pharmaceutical Quality Assurance | Year: 2011

The purpose of study is to formulate and process validation is to create a robust formulation and to validate all the critical parameters challenged in manufacturing process like dry mixing, blending, lubrication, compression, coating and packing. By comparing the results of above challenged parameters, it shown that all the results of three batch's had met the pre determine specification and FDA requirement. Finally by seeing the results we can say that the process followed was correct and are as per c GMP requirements.


Senthil Kumar M.,Annai Veilankannis Pharmacy College | Balasubramanian J.,Annai Veilankannis Pharmacy College | Pavuluri G.,Annai Veilankannis Pharmacy College | Chamarthi H.,Annai Veilankannis Pharmacy College | Madhuri K.,Annai Veilankannis Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2011

A dangerous new mutation that makes some bacteria resistant to almost all antibiotics has become increasingly common throughout the world. Experts in antibiotic resistance called the gene mutation, named NDM-1(New Delhi Metallo-beta-lactamase), "worrying" and "ominous" and they feared it would spread globally. The spreading of this is increasing day by day. So, the scarcity of the antibiotics and the need of these in the present condition show the target to the world. The potential of NDM-1 to be a worldwide public health problem is great, and co-ordinated international surveillance is needed.

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