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Tiruvannāmalai, India

Vijay T.,Bharathiar University | Vijay T.,P.A. College | Rajan M.S.D.,P.A. College | Sarumathy K.,Bharathiar University | And 3 more authors.
Journal of Applied Pharmaceutical Science | Year: 2011

Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with Gmelina arborea (Verbenaceae) were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of Gmelina arborea (GA) against DOX- induced cardiotoxicity in rats. GA was given orally to rats(250&500mg/kg) and DOX (20mg/kg) was administered on the seventh day. GA protected against DOX-induced increased the levels of marker enzymes. It significantly inhibited DOX-provoked glutathione (GSH) depletion in cardiac tissues. The reductions of cardiac activities of catalase (CAT) ,superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Pretreatment of GA significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH). GA alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, GA protects against DOX-induced cardiotoxicity in rats. The study can be attributed, at least in part, to GA's antioxidant activity. Source


Padmalochana K.,Bharathiar University | Padmalochana K.,Sri Akilandeswari Womens College | Sivasankari H.,Anna Bioresearch Foundation
Journal of Applied Pharmaceutical Science | Year: 2013

Cryptolepis buchanani (Berberidaceae) is a climbing tree, leaves is widely used in folk medicine in Southeast Asia. The alcoholic extract of stem of this plant is commonly used for the treatment of inflammatory conditions such as arthritis, and muscle and joint pain. The development of hepatotoxicity induced by acetaminophen is promoted by oxidative stress. The aim of the present study was to investigate the hepatoprotective effect and antioxidant activities ofthe ethanolic extract of Cryptolepis buchanani on acetaminophen induced hepatotoxicity in rats. We observed that the ethanolic extract of cryptolepis buchanani conferred hepatoprotectivity. Biochemical observations confirmed the beneficial roles of Cryptolepis buchanani and silymarin against acetaminophen induced liver injury in rats. Source


Palani S.,Anna Bioresearch Foundation | Raja S.,Bharat Institute of Technology | Kalash R.S.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Toxicological and Environmental Chemistry | Year: 2010

Mahonia leschenaultia takeda (Berberidaceae) (MLT) is a traditional medicinal plant that is commonly used to treat and improve liver and renal conditions in India and other Asian countries. Acetaminophen (APAP) is commonly used as an analgesic and an antipyretic agent that, in high doses, produces liver and kidney necrosis in mammals. The aim of this study was to investigate the nephroprotective and antioxidant activities of the ethanol extract of MLT at two dose levels of 250 and 500 mg kg-1 bw on APAP-induced toxicity in rats. APAP significantly increased levels of serum urea, hemoglobin (Hb), total leukocyte count, creatinine, packed cell volume, DLC, and mean corpuscular volume, raised body weight, and reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet concentration. MLT inhibited the hematological effects of APAP. MLT significantly increased activities of renal superoxide dismutase, catalase, glutathione, and glutathione peroxidase and decreased malondialdehyde content of APAP-treated rats. Apart from these, histopathological changes also showed the protective nature of the MLT extract against APAP-induced necrotic damage of renal tissues. In conclusion, data suggest that the ethanol extract of MLT prevented renal damage from APAP-induced nephrotoxicity in rats and it is likely mediated through antioxidant activities. © 2010 Taylor & Francis. Source


Palani S.,Anna Bioresearch Foundation | Palani S.,PG Research | Raja S.,Bharat Institute of Technology | Naresh R.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Toxicology Mechanisms and Methods | Year: 2010

Plectranthus amboinicus (PA), commonly known as country borage, is a folkoric medicinal plant. Juice from its leaves is commonly used for illnesses including liver and renal conditions in the Asian sub-continent. Acetaminophen (APAP), used as an analgesic, produces liver and kidney necrosis in mammals at high doses. The aim of this study was to investigate the nephroprotective, diuretic, and antioxidant activities of the ethanol extract of PA at two doses of 250 and 500 mg/kg bw on APAP-induced toxicity in rats. This study shows that APAP significantly increases the levels of serum urea (UR), hemoglobin (Hb), total leukocyte count, creatinine, raised body weight, and reduced levels of neutrophils, granulocytes, uric acid, and platelet concentration. Ethanol extract of PA rescued these phenotypes by increasing anti-oxidative responses as assessed by biochemistry and histopathology. In addition, the ethanol extract of PA at two doses showed a significant diuretic activity by increased levels of total urine output and urinary elerolytes such as sodium and potassium. In conclusion, these data suggest that the ethanol extract of PA possess nephroprotective and antioxidant effects against APAP-induced nephrotoxicity and strong diuretics effect in rats. © 2010 Informa UK Ltd. Source


Sakthivel K.,Anna Bioresearch Foundation | Palani S.,Anna Bioresearch Foundation | Selvaraj R.,Anna Bioresearch Foundation | Venkadesan D.,Anna Bioresearch Foundation | And 2 more authors.
Journal of Biological Sciences | Year: 2013

The present study were designed to scientifically evaluate the cardioprotective potential of ethanolic extract of scilla hyacinthina (Family: Hyacinthinae), a medicinal herb, on Doxorubicin (DOX) induced myocardial infarction (MI) in albino rats. DOX is one of the most effective chemotherapeutic drugs in cancer, however, its incidence of cardiotoxicity compromises its therapeutic index. DOX-induced heart failure is thought to be caused by reduction/oxidation cycling of DOX to generate oxidative stress and cardiomyocyte cell death. A Doxorubicin dose of 20 mg kg-1 was selected for the present study as this dose offered significant alteration in biochemical parameters and moderate necrosis in heart. Effect of SHA oral treatment for 14 days at two doses (250 and 500 mg kg-1 b.wt) was evaluated against DOX-induced cardiac necrosis. Significant myocardial necrosis, depletion of endogenous antioxidants and biochemical parameters were observed in DOX-treated animals when compared with the normal animals. The pretreatment with SHA to DOX-induced rats significantly prevented the altered biochemical variation such as marker enzymes (SGPT, SGOT, CPK and LDH), lipid profile (LDL, VLDL, TGs, HDL and Total cholesterol) and antioxidant parameters (SOD, GSH, CAT, GSH-Px, MDA and GR) to near normal status. Serum urea, uric acid and alkaline phosphate, which increased on DOX administration, registered near normal values on pretreatment with SHA. Histology of pretreated with SHA to DOX-induced heart showed a significant recovery from cell damage. The present findings have demonstrated that the cardioprotective effects of SHA in DOX-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation of membrane. © 2013 Asian Network for Scientific Information. Source

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