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Tiruvannāmalai, India

Bharathiraja B.,HIGH-TECH | Ranjith Kumar R.,HIGH-TECH | PraveenKumar R.,Anna Bio Research Foundation | Chakravarthy M.,HIGH-TECH | And 2 more authors.
Bioresource Technology | Year: 2016

In this investigation, oil extraction was performed in marine macroalgae Gracilaria edulis, Enteromorpha compressa and Ulva lactuca. The algal biomass was characterized by Scanning Electron Microscopy and Fourier Transform-Infra Red Spectroscopy. Six different pre-treatment methods were carried out to evaluate the best method for maximum oil extraction. Optimization of extraction parameters were performed and high oil yield was obtained at temperature 55. °C, time 150. min, particle size 0.10. mm, solvent-to-solid ratio 6:1 and agitation rate 500. rpm. After optimization, 9.5%, 12.18% and 10.50 (g/g) of oil extraction yield was achieved from the respective algal biomass. The rate constant for extraction was obtained as first order kinetics, by differential method. Stable intracellular Cal A and Cal B lipase producing recombinant Pichia pastoris was constructed and used as biocatalyst for biodiesel production. Comparative analysis of lipase activity and biodiesel yield was made with immobilized Candida antarctica lipase. © 2016 Elsevier Ltd.


Kumar R.P.,Anna Bio Research Foundation | Bharathiraja B.,HIGH-TECH | Pragadeesh K.,Anna Bio Research Foundation | Chozhavendhan S.,Anna Bio Research Foundation | Johnson A.W.,Anna Bio Research Foundation
Asian Journal of Microbiology, Biotechnology and Environmental Sciences | Year: 2014

Among various environmental issues, waste management is a leading area where the effective and intensive utilisation of wastes and obtaining useful products in biological ways are concentrated. Biochemical characterization of sago industry waste shows that it is rich in carbohydrates, in more specific it contains 55-60% of starch. This work deals with the management of waste for bioethanol production. Native microorganisms were used for converting the sago starch into simple sugars. Amongst them, six bacterial strains were found effective for starch degradation. The co- fermentation to produce ethanol was carried out in six different sets with 5% load of isolated bacterial strains and later by addition of 1% load of Saccharomyces cerevisiae. All the experiments were carried out in laboratory scale Erlenmeyer flasks, incubated in shaking incubator for five days at 35°C. The results show that the strain 3 yielded a biomass of 17.041 g/L thereby producing 2.01 g/L of ethanol.


Bharathiraja B.,HIGH-TECH | Chakravarthy M.,HIGH-TECH | Ranjith Kumar R.,HIGH-TECH | Yogendran D.,HIGH-TECH | And 4 more authors.
Renewable and Sustainable Energy Reviews | Year: 2015

Global outlook of biofuels turns out to be a full-fledged search focusing the viability and sustainability assets. The present day option for immediate and sustainable alternate fuels lies with algal biofuels. Algae are the most sustainable fuel resource in terms of food security and environmental issues. Inefficient and unsustainable biofuel derived from food crops twosome food security issues thus increasing interests towards algal energy. CO2 mitigation, quick biomass accumulation accomplishing simultaneous bioremediation have gathered progressive attention. Cultivation of biomass, harvesting, processing and fuel production by chemical/biochemical reactions are the sequential stages in algal biofuel production. Currently, biofuels produced from algal biomass is not economical since biomass cultivation, processing and separation of fuel products appears costly although certain advancements in culturing techniques have been recently unearthed. Further improvements with the biomass processing strategies may step up the third-generation biofuel concept a profitable one in the near future. This article reviews various cultivation methods, processing techniques and stages in algal biofuel production thereby extensively investigating their potential application in biofuel refineries. © 2015 Elsevier Ltd.All rights reserved.


Naresh R.,Anna Bio Research Foundation | Nazeer Y.,Anna Bio Research Foundation | Palani S.,Anna Bio Research Foundation
Medicinal Chemistry Research | Year: 2013

Cancer is a family of disease in which a group of cells initially undergoes an uncontrollable cell division which ultimately leads to tissue invasiveness. Around 200 different kinds of cancer have been reported so far; on the other hand, numerous small molecules possessing anticancer activity have been discovered by various in vivo and in vitro studies. Although cancer is one among the most studied disease in the world, seeking a cure for cancer is becoming quite challenging to the scientific community. In this study, we aim to find a feasible way to overcome the complexity encountered in predicting the modes of action of anticancer compounds. High-throughput virtual screening were performed on five targets overexpressed in all types of human cancer (VEGFR, SRC kinase, Aurora A, survivin, and HSP90) with the aid of molecular docking simulation. Our study is focused on finding the targets for the anticancer compounds rather than finding new compounds against cancer targets. The molecular docking result not only reflects the specificity of the anticancer compounds toward its protein targets but also highlights the impact of in silico studies in understanding cancer. © 2012 Springer Science+Business Media, LLC.

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