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Yon M.I.,Ankara Teaching and Research Hospital | Titiz A.P.,Ankara Numune Teaching and Research Hospital | Bilen S.,Ankara Numune Teaching and Research Hospital | Ulusoy E.,Develi Hatice Muammer Kocaturk Hospital | And 4 more authors.
Journal of the Pakistan Medical Association | Year: 2016

Objective: To investigate whether there is a relationship between chronic migraine and heat shock protein-70. Methods: The case-control progressive study was conducted at Ankara Numune Teaching and Research Hospital, Ankara, Turkey, from January to June 2013, and comprised patients over 18 years of age who were diagnosed with chronic migraine and did not have any other known neurological illness. Age and gender-matched volunteers with no history of headache or neurological illness were included as controls. In order to exclude other central nervous system diseases, computed tomography and/or magnetic resonance imaging was carried out. Blood samples to evaluate serum heat shock protein-70 levels were obtained from the patients during headache-free periods and from the controls following 8 hours of fasting. The samples were interpreted using the enzyme-linked immunosorbent assay reader. Results: There were 40 controls and an equal number of cases in the study. Mean heat shock protein-70 levels were higher in the cases 2.37±1.91ng/dl compared to thecontrols1.81±1.30 ng/dl, but the difference was not statistically significant (p=0.12). Serum heat shock protein-70 levels were also compared in terms of the duration of migraine disease, frequency of migraine attacks, Visual Analogue Scale score, migraine attack duration and the presence of aura, but no statistically significant difference was found (p=0.13, p=0.17, p=0.90, p=0.68, p=0.95 respectively). Conclusion: Heat shock protein-70 was not a reliable chronic migraine biomarker. © 2016, Pakistan Medical Association. All rights reserved. Source


Imge E.B.,Ankara University | Kilicoglu B.,Ankara Teaching and Research Hospital | Devrim E.,Ankara University | Cetin R.,Ankara Oncology Teaching and Research Hospital | Durak I.,Ankara University
International Journal of Radiation Biology | Year: 2010

Purpose:To evaluate effects of mobile phone use on brain tissue and a possible protective role of vitamin C. Materials and methods:Forty female rats were divided into four groups randomly (Control, mobile phone, mobile phone plus vitamin C and, vitamin C alone). The mobile phone group was exposed to a mobile phone signal (900MHz), the mobile phone plus vitamin C group was exposed to a mobile phone signal (900MHz) and treated with vitamin C administered orally (per os). The vitamin C group was also treated with vitamin C per os for four weeks. Then, the animals were sacrificed and brain tissues were dissected to be used in the analyses of malondialdehyde (MDA), antioxidant potential (AOP), superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase, adenosine deaminase (ADA) and 5′nucleotidase (5′-NT). Results:Mobile phone use caused an inhibition in 5′-NT and CAT activities as compared to the control group. GSH-Px activity and the MDA level were also found to be reduced in the mobile phone group but not significantly. Vitamin C caused a significant increase in the activity of GSH-Px and non-significant increase in the activities of 5′-NT, ADA and CAT enzymes. Conclusion:Our results suggest that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue. © 2010 Informa UK, Ltd. Source


Kavlakoglu B.,Ankara Oncology Teaching and Research Hospital | Pekcici R.,Ankara Teaching and Research Hospital | Akkucuk S.,Ankara Oncology Teaching and Research Hospital | Oral S.,Ankara Oncology Teaching and Research Hospital
Turkiye Klinikleri Journal of Medical Sciences | Year: 2010

Krukenberg tumors are metastases of gastrointestinal and bladder tumors to the ovaries. Krukenberg tumors are frequently diagnosed as huge ovarian tumors. In some cases, they were identified in early stage and curative operation could be performed. We report a case of a 43-year-old woman investigated for acute abdominal pain and found to have a ruptured Krukenberg tumor from colon cancer. In physical examination severe abdominal pain, constipation and signs of peritonitis were seen. Laparotomy and abdominal exploration was performed. Ruptured Krukenberg tumor, left colonic tumor and liver metastasis were found at the time of operation. Left hemicolectomy, right salphingo-oophorectomy and liver biopsy were performed. Postoperative course was uneventful, appropriate chemotherapy regimen was added to treatment. Ruptures of ovarian cysts are one of the significant etiological factors for women with acute abdominal pain. However, Krukenberg tumor rupture related to colon cancer metastases is very rare. © 2010 by Türkiye Klinikleri. Source


Katirci Y.,Ankara Teaching and Research Hospital | Kandis H.,Duzce University | Aslan S.,Ataturk University | Kirpinar I.,Ataturk University
Toxicology and Industrial Health | Year: 2011

Neuropsychiatric sequelae may be observed in the late phases of carbon monoxide (CO) intoxication. Establishing a link between CO-related neuropsychiatric disorders and associated risk factors may decrease morbidity and mortality by means of appropriate treatment and counseling. The aim of the present study was to determine the relationship between neuropsychiatric outcomes of CO intoxication and demographic and clinical variables. Thirty patients who presented with CO intoxication and had no known neuropsychiatric disease, and 30 healthy controls were included. Physical examinations and laboratory tests were performed. Following the 1st therapy, they underwent mental and psychiatric tests 5 times (the time of discharge, during the 1st week, and during the 1st, 3rd, and 6th months). They underwent cerebral magnetic resonance imaging (MRI) at the end of the 1st month. They were evaluated by cognitive function tests at the 6th month. Lesions relevant to CO intoxication were detected in 46.7% of the patients via cranial computed tomography and in 13.3% via MRI. Evaluation of psychiatric tests revealed a clear decrease in cognitive functions, such as immediate memory, learning, reaching the criterion, spontaneous recall, attention, visual memory, and logical memory. It was found that the patients had anxiety within the 1st month, and the frequency of anxiety reached to the value of the control group by the end of the 6th month. In conclusion, we suggested that CO intoxication might lead to neuropsychiatric disorders. Our results emphasized that in addition to standard treatment, neuropsychiatric evaluation should also be performed in patients with CO intoxication. © 2010 The Author(s). Source


Kurt O.K.,Research Hospital | Alpar S.,Research Hospital | Sipit T.,Research Hospital | Guven S.F.,Research Hospital | And 5 more authors.
American Journal of Emergency Medicine | Year: 2010

The aim of this study was to evaluate the diagnostic contribution of alveolar dead space fraction (AVDSf) measured using capnography in patients admitted with suspected pulmonary embolism (PE). A total of 58 patients who were admitted to our hospital with suspected PE between October 2006 and January 2008 were included in this study. All patients were assessed using the Wells clinical score, capnography, computed tomographic pulmonary angiography, D-dimer measurement, lower-extremity venous Doppler ultrasonography, and V/Q scintigraphy. Forty patients (69%) had PE based on computed tomographic pulmonary angiography findings. The AVDSf value with the highest sensitivity and specificity, which was at the same time statistically significant, was 0.09. This value was consistent with the AVDSf value obtained using receiver operating characteristic analysis. In our study, the sensitivity of capnography was 70%, with a specificity of 61.1%, positive predictive value of 80%, and negative predictive value of 47.8%. The use of AVDSf in combination with any of the several scoring systems that evaluate clinical likelihood of PE and D-dimer levels resulted in higher sensitivity and specificity rates for the diagnosis of PE. © 2010 Elsevier Inc. All rights reserved. Source

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