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Kucukazman M.,Kecioren Teaching and Research Hospital | Ata N.,Kecioren Teaching and Research Hospital | Dal K.,Kecioren Teaching and Research Hospital | Yeniova A.O.,Kecioren Teaching and Research Hospital | And 10 more authors.
Clinics | Year: 2014

OBJECTIVE: Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS: We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease. RESULTS: The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl). CONCLUSIONS: In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed. © 2014 CLINICS.

Imge E.B.,Ankara University | Kilicoglu B.,Ankara Teaching and Research Hospital | Devrim E.,Ankara University | Cetin R.,Ankara Oncology Teaching and Research Hospital | Durak I.,Ankara University
International Journal of Radiation Biology | Year: 2010

Purpose:To evaluate effects of mobile phone use on brain tissue and a possible protective role of vitamin C. Materials and methods:Forty female rats were divided into four groups randomly (Control, mobile phone, mobile phone plus vitamin C and, vitamin C alone). The mobile phone group was exposed to a mobile phone signal (900MHz), the mobile phone plus vitamin C group was exposed to a mobile phone signal (900MHz) and treated with vitamin C administered orally (per os). The vitamin C group was also treated with vitamin C per os for four weeks. Then, the animals were sacrificed and brain tissues were dissected to be used in the analyses of malondialdehyde (MDA), antioxidant potential (AOP), superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase, adenosine deaminase (ADA) and 5′nucleotidase (5′-NT). Results:Mobile phone use caused an inhibition in 5′-NT and CAT activities as compared to the control group. GSH-Px activity and the MDA level were also found to be reduced in the mobile phone group but not significantly. Vitamin C caused a significant increase in the activity of GSH-Px and non-significant increase in the activities of 5′-NT, ADA and CAT enzymes. Conclusion:Our results suggest that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue. © 2010 Informa UK, Ltd.

Erguder B.I.,Ankara University | Cetin M.,Ankara Oncology Teaching and Research Hospital | Namuslu M.,Ankara University | Kilicoglu S.,Ufuk University | And 3 more authors.
Medicinal Chemistry Research | Year: 2010

The purpose of this study was to investigate effects of ionic highosmolar contrast medium on oxidative metabolism in liver, urinary bladder, and ovary tissues and to obtain information about possible protective effects of vitamin C. Twenty-one female rats, 14 weeks old, were used in this study. They were divided into three groups of seven rats: Sham (group I), contrast (group II), contrast + vitamin C (group III). Vitamin C was given orally to the animals in group III during the study period. On the fifth day, contrast medium was given via intravenous infusion as a single dose to the animals in groups II and III. On the sixth day of the study, the animals were killed with anesthesia by ketamine hydrochloride. Then, their liver, bladder, and ovary tissues were removed to measure analyses parameters. Our results suggested that contrast medium led to some increases in malondialdehyde levels in the liver, bladder, and ovary tissues and that vitamin C prevented these increases in the tissues. Nitric oxide level also was found to increase in the contrast-treated animals and vitamin C prevented this increase in the liver tissue. Ionic high-osmolar contrast medium leads to weak oxidant stress in rat liver, bladder, and ovary tissues, and vitamin C prevents this oxidant stress. © Birkhäuser Boston 2009.

Ulas A.,Ankara Ataturk Training and Research Hospital | Turkoz F.P.,Ankara Oncology Teaching and Research Hospital | Silay K.,Yildirim Beyazit University | Tokluoglu S.,Ankara Oncology Teaching and Research Hospital | And 3 more authors.
PLoS ONE | Year: 2014

Purpose: We aimed to establish a laboratory prognostic index (LPI) in advanced non-small cell lung cancer (NSCLC) patients based on hematologic and biochemical parameters and to analyze the predictive value of LPI on NSCLC survival. Copyright:Patients and Methods: The study retrospectively reviewed 462 patients with advanced NSCLC diagnosed between 2000 and 2010 in a single institution. We developed an LPI that included serum levels of white blood cells (WBC), lactate dehydrogenase (LDH), albumin, calcium, and alkaline phosphatase (ALP), based on the results of a Cox regression analysis. The patients were classified into 3 LPI groups as follows: LPI 0: normal; LPI 1: one abnormal laboratory finding; and LPI 2: at least 2 abnormal laboratory findings.Results: The median follow up period was 44 months; the median overall survival (OS) and median progression-free survival (PFS) were 11 and 6 months, respectively. A multivariate analysis revealed that the following could be used as independent prognostic factors: an Eastern Cooperative Oncology Group performance status score (ECOG PS) ≥2, a high LDH level, serum albumin >3 g/ dL, serum calcium.10.5 g/dL, number of metastases >2, presence of liver metastases, malignant pleural effusion, or receiving chemotherapy ≥4 cycles. The 1-year OS rates according to LPI 0, LPI 1, and LPI 2 were 54%, 34%, and 17% (p<0.001), respectively and 6-month PFS rates were 44%, 27%, and 15% (p<0.001), respectively. The LPI was a significant predictor for OS (Hazard Ratio (HR): 1.41; 1.05-1.88, p<0.001) and PFS (HR: 1.48; 1.14-1.93, p<0.001).Conclusion: An LPI is an inexpensive, easily accessible and independent prognostic index for advanced NSCLC and may be helpful in making individualized treatment plans and predicting survival rates when combined with clinical parameters. © 2014 Ulas et al.

Ulas A.,Ankara Ataturk Training and Research Hospital | Tokluoglu S.,Ankara Oncology Teaching and Research Hospital | Kos M.,Duzce University | Silay K.,Yildirim Beyazit University | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Purpose: In this study, we aimed to evaluate the effects of sex-based non-small cell lung cancer (NSCLC) varieties on survival rates. Materials and Methods: A retrospective study was performed in patients with NSCLC who were diagnosed by histological methods between the years 2000 and 2010. A chi-square test was used to compare variables. Overall survival (OS) was estimated by the Kaplan-Meier method. Results: Of the 844 patients, 117 (13.9%) were women and 727 (86.1%) were men. Adenocarcinoma was more common in women than in men (p<0.0001). There were more women non-smokers than men (p<0.0001). There was no statistically significant difference in ECOG PS, weight loss>10%, stage, LDH, albumin and treatment between women and men. Women younger than 65 years (17.0 vs 12.0 months; p=0.03), who had adenocarcinoma histology (15.0 vs 10.0 months; p=0.006) and who had a hemoglobin level ≥12g/dL (18.0 vs 12.0 months; p=0.01) were found to have a better median OS rate than men. Median OS rates were found to be 13.0 months in females and 12.0 months in males (p=0.14). Among metastatic patients, the median OS was 11.0 months in females and 8.0 months in males (p=0.005). Among stage IIIB and stage IV patients who had first line platinum-based chemotherapy, the median OS was 17.0 months in women and 11.0 months in men (p=0.002). The response rate of chemotherapy was higher in women than in men (p=0.03). Conclusions: In our study, we found that survival duration is longer and chemotherapy response is better in women with NSCLC who do not have anemia or comorbidities and who are mostly non-smokers with adenocarcinomas. Further studies regarding the causes of these differences may provide clarity on this subject.

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