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Onal I.K.,Ankara Oncology Education and Research Hospital
Scandinavian Journal of Gastroenterology

There are several causes for folate deficiency in Crohn's disease: malnutrition, malabsorption, excess folate utilization and medications. A combination of these factors may be responsible for the deficiency of this vitamin in some cases. © Informa Healthcare. Source

Turanli S.,Ankara Oncology Education and Research Hospital
Langenbeck's Archives of Surgery

Background and aims: To investigate whether isolated bone metastases at the time of diagnosis is a different entity than bone metastases after breast cancer surgery. Patients and methods: One hundred thirty-nine patients were examined between June 2004 and January 2007. These patients were classified into synchronous (group I) and metachronous groups (group II) depending on time to development of bone metastases. Patients and tumor characteristics, treatment, clinical progression, and survival were compared for each group. Results: There were 44 patients in group I and 95 patients in group II. The median follow-up time was 36 months. The two groups showed similar results when patients, tumor characteristics, and clinical progression were compared. In the groups, the median time to progression was 14 vs 13 months (p∈=∈0.70), and median overall survival was 47 vs 46 months (p = 0.96), respectively. Conclusion: Development time of bone metastasis has no effect on clinical progression, time to progression, and overall survival in breast cancer. © 2009 Springer-Verlag. Source

Turanli S.,Ankara Oncology Education and Research Hospital
Indian Journal of Surgery

Purpose: Surgery for gastric cancer with synchronous liver metastasis is applied for palliation. The aim was to determine whether surgical removal of the primary tumor provides a better survival and disease progression Methods: Sixty-two patients are classified according to the primary tumor were removed or not. Patients and tumor characteristics, removal of the primary tumor are examined as the factors that were affecting overall survival and metastatic progression-free survival. Results: The mean follow-up time was 243±23 days. The mean survival of the resection and nonresection groups were 422±50 and 170±16 days (p = 0.0001), respectively. After adjustment for other covariates, resection was associated with a trend toward improvement in overall survival (p = 0.003; relative risk RR: 0.34; 95% confidence interval (CI): 0.17-0.66) and improvement in metastatic progression-free survival (p = 0.07, RR = 0.51; 95% CI: 0. 25-1.07). Conclusions: Excision of the primary tumor has an effect on metastatic progression-free survival and overall survival. © 2010 Association of Surgeons of India. Source

Kuru B.,Ondokuz Mayis University | Gulcelik N.E.,Hacettepe University | Gulcelik M.A.,Urankent sitesi E 3 blok | Gulcelik M.A.,Ankara Oncology Education and Research Hospital | Dincer H.,Ankara Oncology Education and Research Hospital
Langenbeck's Archives of Surgery

fine-needle aspiration cytology (FNAC) for diagnosing thyroid carcinoma in thyroid nodules < 4 cm versus ≥4 cm. Materials and methods Six hundred sixty-two patients with thyroid nodules who underwent FNAC and surgery at our institution were analyzed. The association of predictive factors with thyroid carcinoma was evaluated. The sensitivity, specificity, and the false-negative rate of FNAC were calculated. Results The incidence of thyroid carcinoma was significantly higher in nodules ≥4 cm (24%) compared with nodules <4 cm (12%). The false-negative rates of FNAC were 2% in all nodules and 1.3% and 4.3% in nodules <4 cm and ≥4 cm (p=0.9), respectively. Sensitivity and specificity of FNAC were 90% and 79%, respectively. Conclusions The false-negative rate of FNAC is low for thyroid nodules <4 cm and for nodules ≥4 cm. © Springer-Verlag 2009. Source

Kayaalti Z.,Ankara University | Sahiner L.,Ankara Oncology Education and Research Hospital | Durakoglugil M.E.,Ankara Oncology Education and Research Hospital | Soylemezoglu T.,Ankara University
Archives of Gerontology and Geriatrics

Aging is determined as the product of an interaction among genetic, environmental and lifestyle factors. As interleukin-6 (IL-6) and metallothioneins (MTs) are related to inflammation and oxidative stress response, their genes are appropriate candidate for aging, age related diseases and infections. The aim of this study was to investigate the association between the IL-6 -174 G/C promoter region and MT2A -5 A/G core promoter region single nucleotide polymorphisms (SNPs) with longevity in Turkish population. Blood samples were collected from 354 individuals between 18 and 95 years of age. Individuals were classified into four groups according to their ages as 20-40, 41-60, 61-80, >80. IL-6 and MT2A polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Mean ages of individuals with IL-6 -74 C - carriers and C + carriers were 49.82±20.45 years and 59.82±16.82 years, respectively. For the MT2A polymorphism, mean ages were estimated as 56.18±19.50 years for G - carriers and 47.59±13.45 years for G + carriers. As a result, when the IL-6 and MT2A polymorphisms were compared with the mean ages and age groups, statistically significant associations were found (p<0.001 and p<0.05, respectively). In conclusion, these data support that the IL-6 -174 C + carriers and MT2A -5 G - carriers may be more advantageous for longevity. © 2011 Elsevier Ireland Ltd. Source

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