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Oksuzoglu B.,Ankara Numune Training and Education Hospital | Tosun O.,Ataturk Training and Education Hospital | Ustun H.,Ankara Training and Education Hospital
Journal of Craniofacial Surgery | Year: 2010

A rare case of leiomyosarcoma in the neck was presented. Several common characteristics of head and neck leiomyosarcoma were summarized in this case: the low-grade behavior of this tumor, the difficulty of aspiration cytology to provide accurate morphologic classification of this like most other soft tissue tumors, the necessity for appropriate immunohistochemical investigation for accurate diagnosis, the nonspecificity of the radiologic findings, the necessity for en bloc three-dimensional resection of the tumor with adequate soft tissue margins that is actually the mainstay of treatment in this type of cancer, and the propensity to metastasize to distant organs. Copyright © 2010 by Mutaz B. Habal, MD.

Akbulut S.,Kartal Kosuyolu High Specialty Education and Research Hospital | Altiparmak E.,Ankara Numune Training and Education Hospital | Topal F.,Cankiri State Hospital | Ozaslan E.,Ankara Numune Training and Education Hospital | And 2 more authors.
World Journal of Gastroenterology | Year: 2010

AIM: To investigate serum levels of homocysteine (Hcys) and the risk that altered levels carry for thrombosis development in ulcerative colitis (UC) patients. METHODS: 55 UC patients and 45 healthy adults were included. Hcys, vitamin B12 and folic acid levels were measured in both groups. Clinical history and thrombo-embolic events were investigated. RESULTS: The average Hcys level in the UC patients was 13.3 ± 1.93 ummol/L (range 4.60-87) and was higher than the average Hcys level of the control group which was 11.2 ± 3.58 ummol/L (range 4.00-20.8) (P < 0.001). Vitamin B12 and folic acid average values were also lower in the UC group (P < 0.001). When multivariate regression analysis was performed, it was seen that folic acid deficiency was the only risk factor for hyperhomocysteinemia. Frequencies of thromboembolic complications were not statistically significantly different in UC and control groups. When those with and without a thrombosis history in the UC group were compared according to Hcys levels, it was seen that there were no statistically significant differences. A negative linear relationship was found between folic acid levels and Hcys. CONCLUSION: We could not find any correlations between Hcys levels and history of prior thromboembolic events. © 2010 Baishideng.

Cakmak M.,Ankara University | Yilmaz H.,Dr Ay Ankara Oncology Training And Research Hospital | Baglar E.,Ankara University | Darcin T.,Agri State Hospital | And 6 more authors.
Clinical and Experimental Hypertension | Year: 2015

Background: Endocan, a cysteine-rich dermatan sulfate proteoglycan expressed by endothelial cells, is seemed to be a new biomarker for endothelial dysfunction. Pre-eclampsia (PE) is characterized by the new onset of hypertension, proteinuria after 20 weeks of gestation, placental vascular remodeling, systemic vascular inflammation and endothelial dysfunction. The aim of this study was to investigate the relationship of PE and its severity with serum endocan levels. Methods: A cross-sectional study was performed. Serum was collected from women with PE and normotensive controls. Serum endocan and tumor necrosis factor alpha (TNF-α) concentrations were measured by a specific enzyme linked immunosorbent assay. Results: Patients with PE had significantly higher median (interquartile range) endocan and mean TNF-α concentrations than controls [20.04 (12.26) ng/mL vs 15.55 (6.19) ng/mL, p < 0.001 for endocan; 26.49 ± 12.14 pg/mL vs 14.62 ± 5.61 pg/mL, p < 0.001 for TNF-α; respectively]. Serum endocan concentrations were positively correlated with systolic blood pressure (r = 0.618, p < 0.001), diastolic blood pressure (r = 0.608, p < 0.001), the amount of 24-h proteinuria (r = 0.786, p < 0.001) and TNF-α (r = 0.474, p < 0.001) in women with PE. In subgroup analysis, patients with severe PE had significantly higher endocan concentrations than those with mild PE. Receiver operating characteristic analysis of endocan was used to identify the patients with PE and also discriminating between mild and severe PE. Conclusion: Serum endocan concentrations were significantly elevated in women with PE versus normotensive controls, and concentrations seem to be associated with the severity of the disease. © 2015 Taylor & Francis Group, LLC.

Celik H.T.,Ankara University | Abusoglu S.,Selcuk University | Burnik S.F.,Endocrinology Clinic | Sezer S.,Ankara Numune Training and Education Hospital | And 6 more authors.
Endocrine Regulations | Year: 2013

objective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (T 2) response. γ-interferon is also produced by T helper 1 (T 1) cells to induce cellular responses. γ-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. Te aim of this study was to investigate the serum levels of IL-33 and γ-interferon in different thyroid disorders. Methods. Twenty patients with Graves' disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and γ-interferon tests were analyzed from 89 participants. Serum IL-33 and γ-interferon analyses were performed by enzyme-linked immunosorbent assay. results. Tere was no statistically significant difference between groups for serum γ-interferon levels. Serum IL-33 concentrations were significantly higher in Graves' disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000). Conclusions. Te correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves' disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods.

Ozdemir O.,Ankara Numune Training and Education Hospital | Sari M.E.,Ankara Numune Training and Education Hospital | Atalay C.R.,Ankara Numune Training and Education Hospital | Kurban Y.,Kecioren Education and Research Hospital | And 2 more authors.
Journal of Experimental Therapeutics and Oncology | Year: 2015

Lymphangiomas are rare benign tumors which are generally seen in pediatric population and the etiopathogenesis has not yet been understood. They occasionally occur in the head and neck or axillary region with only 5% of them being located in the abdominal or mediastinal cavity. These tumors may be asymptomatic or may cause acute abdominal symptoms due to the location and extention. In the English literature, only 4 cases of lymphangioma were reported to have occurred in the pregnancy period. Herein, we report a case of cystic lymphangioma of the lesser omentum detected incidentally on the ultrasonogram of a 21 year-old, 26-week pregnant woman. The patient was followed up uneventfully during pregnancy. Caesarean section was performed due to transverse presentation of the fetus, and the tumor was completely resected during the same session. The patient is recurrence-free after 1 year of postoperative follow-up. © 2015 Old City Publishing, Inc.

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