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Acar U.,Hacettepe University | Acar D.E.,Zekai Tahir Burak Womens Health Research and Education Hospital | Tanriverdi C.,Istanbul University | Acar M.,Dskap Yldrm Beyazt Research and Education Hospital | And 3 more authors.
Ocular Immunology and Inflammation | Year: 2016

Purpose: To compare the lowering effects of ketorolac 0.4% and nepafenac 0.1% on aqueous and vitreous humor prostaglandin E2 (PGE2) levels in rabbits. Methods: Ketorolac and nepafenac ophthalmic solutions were administered to the right eyes of 24 healthy rabbits after randomized division into two groups. The left eyes of these rabbits were considered as controls for the two groups. On the 4th day of the experiment, the samples were taken from the aqueous and vitreous humors of the rabbits bilaterally, and PGE2 levels were measured by an enzyme immune assay kit. Results: Ketorolac and nepafenac achieved a statistically significant decrease (p<0.001, for each) in PGE2 levels in the aqueous (11.75 ± 6.15 and 14.75 ± 7.60 pg/mL, respectively) and the vitreous humor (6.58 ± 4.62 and 9.83 ± 4.55 pg/mL, respectively). Conclusions: Both ketorolac and nepafenac inhibited PGE2 levels in both the aqueous and vitreous humors of rabbits. Although PGE2-lowering effects were similar in the aqueous humor, nepafenac seemed to be more potent than ketorolac in the vitreous humor. © 2016, Informa Healthcare. All rights reserved. Source


Lafci G.,Turkiye Yuksek Ihtisas Hospital | Yasar E.,Turkiye Yuksek Ihtisas Hospital | Cicek O.F.,Turkiye Yuksek Ihtisas Hospital | Irdem A.,Turkiye Yuksek Ihtisas Hospital | And 2 more authors.
Asian Cardiovascular and Thoracic Annals | Year: 2014

A median sternotomy is the most common approach for cardiac and great vessel surgery. After a median sternotomy, healing complications such as instability, nonunion, and infection, are rare but devastating. Predisposing factors for sternal complications are old age, diabetes, steroid treatment, postmenopause state, obesity, reoperation, and the use of bilateral internal mammary arteries. Patients with sternal dehiscence frequently require reoperation to maintain optimum sternal stability. The technique chosen for sternal closure must provide excellent sternal approximation. We describe a modified Robicsek procedure reinforced with figure-of-8 sternal wires. We named this technique "double-check". © 2013 The Author(s). Source


Yazgan S.,Bulent Ecevit University | Celik U.,Istanbul Medeniyet University | Isk M.,Bulent Ecevit University | Yesil N.K.,Ankara Research and Education Hospital | And 4 more authors.
International Ophthalmology | Year: 2016

To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveitis recurrences were analyzed retrospectively between May 2013 and October 2015. Assessment criteria were uveitis activity, the number of recurrence of uveitis, visual acuity, systemic corticosteroid, or other drug requirement for maintenance of remission of AU. Twelve patients (15 eyes) with HLA-B27-positive ankylosing spondylitis and anterior uveitis have been treated with golimumab 50 mg/month. Remission of uveitis was observed in 12 eyes out of 15. Malign hypertension developed in one subject after the second dose of golimumab therefore the treatment was stopped and this subject was excluded from the study. Median follow-up time was 11 months (interquartile range: 8–18). No uveitic reaction was seen except in the patient who stopped treatment. No topical or systemic steroid necessity was needed except in two cases with oral 4 mg systemic maintenance. Visual acuity was significantly increased (p = 0.002). Golimumab may be a new and effective choice for maintaining remission and the prevention of recurrences of severe, resistant anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. © 2016 Springer Science+Business Media Dordrecht Source


Ozge A.,Mersin University | Selekler M.,Atasehir Memorial Hospital | Ozturk M.,Bakirkoy Research and Education Hospital | Baykan B.,Istanbul University | And 10 more authors.
Geriatrics and Gerontology International | Year: 2015

Aim: Chronic migraine is a growing and disabling subtype of migraine with different risk factors and clinical features, even in older adults. We sought to define and differentiate clinical features of chronic migraine in older adults. We also aimed to compare major clinical features of chronic migraine in older adults with those in younger people of both sexes. Methods: We used electronic dataset (Turkish Headache Database) from 13 tertiary headache centers in Turkey. Electronic dataset included detailed headache-defining features according to ICHD-II criteria based on face-to-face interviews and examination by a headache specialist. Using statistical methods, clinical variables of chronic migraine in older adults were compared with those of younger adults. We included 915 patients with chronic migraine (mean age 43.80±13.95 years); 83.3% were females. In total, 301 patients (32.9%) with chronic migraine aged >50 years were compared with 614 patients aged <50 years. Results: There was no significant change in men with increasing age. However, duration of headache history, severity of attacks, previous histories of motion sickness and positive family history of headaches were significantly different in women with increasing age. Further sex-related differences have been shown in parameters such as attack duration, quality and associated nausea. Conclusion: Chronic migraine is an infrequent type of migraine and shows age-related changes in some phenotypic characteristics, such as severity of attacks, especially in women aged older than 50 years. Furthermore, positive family history of headaches and history of motion sickness increase the likelihood of developing chronic migraine in older women, indicating involvement of some gender-related, but as-yet unknown, genetic factors. Geriatr © 2014 Japan Geriatrics Society. Source


Kutun S.,Ankara Oncology Research and Training Hospital | Ay A.A.,Ankara Oncology Research and Training Hospital | Ulucanlar H.,Ankara Oncology Research and Training Hospital | Tarcan O.,Ankara Oncology Research and Training Hospital | And 5 more authors.
South African Journal of Surgery | Year: 2010

Objective. We evaluated the efficacy of local nitroglycerin application in preventing and treating flap complications after modified radical mastectomy in a large patient cohort. Patients and methods. Between 1993 and 2008, 6 426 patients undergoing surgery for stage Il breast cancer were enrolled in this prospective study. Patients were randomised into treatment and control groups. In the treatment group a nitroglycerin preparation (Nitroderm) was applied to the flap area. Major complications, recovery periods, menopausal status, additional diseases (diabetes mellitus, hypertension, atherosclerotic heart disease) and adverse effects related to nitroglycerin use were recorded. Results. The recovery rate without major complications was statistically significantly higher in the nitroglycerin-treated group than in the controls (p<0.001). Conclusion. Our results indicate that topical nitroglycerin reduces flap complications after breast surgery. Source

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