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Coskan A.S.,Ankara University | Onal B.,Ankara Diskapi YB Training and Research Hospital | Alcigir M.E.,Ankara University | Kutsal O.,Ankara University
Ankara Universitesi Veteriner Fakultesi Dergisi | Year: 2013

Veterinary cytology is gaining importance in diagnostics of skin and subcutaneous masses of dogs. A case of canine-hemangiopericytoma was described by cytopathological and histopathological findings on Fine needle aspiration (FNA) and excisional biopsy. A 13-year-old female terrier dog had a subcutaneous lesion on right leg. FNA was performed by the cytopathologist using 27-gauge needle and 10 ml. syringe attached to a syringe-holder. FNA and imprint slides from FNA aspirates and stained with May-Grunwald Giemsa,Papanicalau, Hematoxylin Eosin were prepared. Cyto-diagnosis was encountered with spindle cells. FNA can often provide information for a good diagnostic and management plan, especially for discrete, non-ulcerated lesions, allowing veterinarians to make more informed therapeutic choices. Source


Kurt R.K.,Mustafa Kemal University | Dogan A.C.,Zekai Tahir Burak Womens Health Training and Research Hospital | Dogan M.,Hacettepe University | Albayrak A.,Ankara Diskapi YB Training and Research Hospital | And 8 more authors.
Reproductive Sciences | Year: 2015

Objective: The aim of the present study is to investigate the efficiency of colchicine in the experimental rat ovarian torsion model in the light of histological and biochemical data. Study Design: A total of 35 Wistar albino female rats were randomly divided into 5 groups, group 1: (control-sham operated, n = 7); group 2: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion; group 3: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion; group 4: (torsion/ detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion and a signal dose of oral 1 mL/kg colchicine; and group 5: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion and 5 days of oral 1 mg/kg colchicine. Histopathologic evaluation was performed by a scoring that assesses congestion, bleeding, edema, and cellular degeneration in the ovarian tissue. Catalase, tissue malondialdehyde (MDA), and protein carbonyl levels were calculated. Results: The histopathologic scores, MDA, and protein carbonyl levels in the control and colchicine groups were significantly lower than groups 2 and 3 (P < .001). Catalase activities were significantly higher in the control and colchicine groups than in groups 2 and 3 (P < .001). The results of the histopathologic parameters and biochemical markers showed that protective effects of colchicine treatment persisted up to 5 days. Conclusion: Our study results revealed that colchicine reduced ovarian ischemia-reperfusion injury in experimental rat ovarian torsion model. As the ovarian detorsion is the first choice of the treatment modality in the early phase, antioxidant and anti-inflammatory treatment modalities like colchicine might be used to reduce ovarian ischemia-reperfusion injury. © 2014 The Author(s). Source


Yucens B.,Ankara Numune Training and Research Hospital | Kuru E.,Ankara Diskapi YB Training and Research Hospital | Safak Y.,Ankara Diskapi YB Training and Research Hospital | Karadere M.E.,Hitit University | Turkcapar M.H.,Hasan Kalyoncu University
Comprehensive Psychiatry | Year: 2014

Introduction: According to the cognitive model, the common mechanism underlying all psychological disorders is distorted or dysfunctional thoughts that affect mood and behaviors. Dysfunctional thoughts predispose an individual to depression and are among the processes that form the basis of personality traits. Elucidating the personality beliefs associated with depression and dysfunctional thoughts is important to understanding and treating depression. The aim of the present study is to determine whether depressed patients exhibited pathological personality beliefs compared with healthy controls. Furthermore, we investigated which personality beliefs were more common among such depressed patients. Methods: A total of 70 patients who were admitted to the Department of Psychiatry at Ankara Diskapi Yildirim Beyazit Training and Research Hospital (Ankara, Turkey) and diagnosed with major depressive disorder according to The Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnostic criteria were included in the study. Additionally, 70 healthy controls matched for age, marital status, and education were included in the study. The Sociodemographic Data Form and Personality Belief Questionnaire-Short form (PBQ-SF) were administered to the participants. Results: A comparison of the depression group with the healthy controls revealed higher scores in dependent, passive-aggressive, obsessive-compulsive, antisocial, histrionic, paranoid, borderline, and avoidant personality subscales in the depressive group. Conclusions: These results suggest that personality beliefs at the pathological level are more common in depressive patients and that the detection of these beliefs would be useful for predicting the prognosis of the disease and determining appropriate treatment methods. © 2014. Source


Keskin Kurt R.,Mustafa Kemal University | Dogan A.C.,Zekai Tahir Burak Womens Health Training and Research Hospital | Dogan M.,Hacettepe University | Albayrak A.,Ankara Diskapi YB Training and Research Hospital | And 8 more authors.
Journal of Obstetrics and Gynaecology Research | Year: 2015

Aim The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and Methods Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion-detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion-detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. Results Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. Conclusion Our study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology. Source

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