Ankara Childrens Hematology and Oncology Training Hospital

Ankara, Turkey

Ankara Childrens Hematology and Oncology Training Hospital

Ankara, Turkey

Time filter

Source Type

Bulut T.,Ankara Childrens Hematology and Oncology Training Hospital | Demirel F.,Ankara University | Demirel F.,Ankara Childrens Hematology and Oncology Training Hospital | Metin A.,Ankara Childrens Hematology and Oncology Training Hospital
Journal of Pediatric Endocrinology and Metabolism | Year: 2017

Dyslipidemia increases the frequency and severity of micro and macrovascular complications of type 1 diabetes (T1D). The present study aims to determine the prevalence of dyslipidemia and its association with clinical and laboratory findings in diabetic children and adolescents. The study included 202 children and adolescents with T1D. Demographic data and laboratory findings were obtained from patients files. Dyslipidemia prevalence was found to be 26.2%. Hypercholesterolemia (15.8%) and hyperglyceridemia (12.9%) were most common findings. Age, body mass index (BMI), hemoglobin A1c (A1C) and poor metabolic control were significantly higher in cases with dyslipidemia. Smoking rate was 14.1% in the pubertal group. Poor metabolic control and dyslipidemia was found higher among smokers (p<0.05). Blood lipid levels should be monitored regularly and nutrition education should be repeated periodically to prevent and control dyslipidemia in patients with T1D. Smoking-related risks should be a part of patient education in the pubertal period. © 2017 Walter de Gruyter GmbH, Berlin/Boston.


Akman A.O.,Ankara Childrens Hematology And Oncology Training Hospital | Basaran O.,Ankara Childrens Hematology And Oncology Training Hospital | Ozyoruk D.,Ankara Childrens Hematology And Oncology Training Hospital | Han U.,Ankara Dskap Yldrm Beyazt Training and Research Hospital | And 2 more authors.
European Journal of Pediatrics | Year: 2016

Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. Conclusion: MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children.What is Known•Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision.•The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement.What is New•A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.•In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis. © 2015, Springer-Verlag Berlin Heidelberg.


PubMed | Ankara Dskap Yldrm Beyazt Training and Research Hospital and Ankara Childrens Hematology and Oncology Training Hospital
Type: Journal Article | Journal: European journal of pediatrics | Year: 2016

Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children. What is Known Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision. The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement. What is New A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.


Komsu-Ornek Z.,Zonguldak Karaelmas University | Demirel F.,Ankara Childrens Hematology and Oncology Training Hospital | Dursun A.,Zonguldak Karaelmas University | Ermis B.,Sakarya University | And 2 more authors.
Turkish Journal of Pediatrics | Year: 2012

The aim of the study was to investigate the relationship between leptin receptor gene (LEPR) Gln223Arg polymorphism and obesity in Turkish children. Ninety-two obese and 99 lean children (between 5-15 years) were included in the study. Twenty-three of the obese children were diagnosed with metabolic syndrome. Blood samples were collected for morning fasting blood glucose, insulin, leptin, and lipid level measurements. LEPR Gln223Arg polymorphism was analyzed by restriction fragment length polymorphism. Significant differences were observed in anthropometric measurements, fasting blood glucose, insulin, leptin, and lipid levels between obese and lean children. Serum leptin levels were markedly higher in obese children. No significant association was noted between Gln223Arg polymorphism and serum leptin, insulin and lipid levels. There were no differences in the genotype frequencies or allele distribution for Gln223Arg polymorphism among obese, obese with metabolic syndrome and lean children. Our findings suggest that there is no association between Gln223Arg polymorphism and obesity in Turkish children.


Demirel F.,Ankara Childrens Hematology and Oncology Training Hospital | Kara O.,Ankara Childrens Hematology and Oncology Training Hospital | Tepe D.,Ankara Childrens Hematology and Oncology Training Hospital | Esen I.,Ankara Childrens Hematology and Oncology Training Hospital
Turkish Journal of Medical Sciences | Year: 2014

Aim: To determine the prevalence of and risk factors for decreased bone mineral density (BMD) and vitamin D deficiency in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: This study was conducted on 30 girls and 22 boys with CAH (age range = 5-20 years) with median age of 12.0 years. BMD values of lumbar vertebras (L1-L4), which were determined by dual-energy X-ray absorptiometry, were used to calculate z-scores according to chronological age. A serum 25-hydroxyvitamin D level of <15 ng/mL was considered as indicative of vitamin D deficiency. Results: Mean vitamin D level was 14.8 ng/mL in the whole group. Twenty-seven (51.9%) children had vitamin D deficiency and it was more prevalent during pubertal ages. Vitamin D levels were found to be significantly lower in pubertal females. BMD z-score was below-1 standard deviation in 40.1% of cases with significantly higher mean age and lower vitamin D levels. Conclusion: Decreased BMD z-score and vitamin D deficiency were common in these children with CAH. Vitamin D levels were significantly lower in girls and pubertal children. Decreased BMD z-score was related to older age and lower levels of vitamin D. Periodical controls of vitamin D status and vitamin D supplementation were recommended in these cases, whenever required. © TÜBİTAK.


Demirel F.,Ankara Childrens Hematology and Oncology Training Hospital | Kara O.,Ankara Childrens Hematology and Oncology Training Hospital | Esen I.,Ankara Childrens Hematology and Oncology Training Hospital
Journal of Pediatric Endocrinology and Metabolism | Year: 2012

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare syndrome characterized by complete or partial agenesis of the uterus and vagina, due to a congenital defect of the Mullerian duct. Affected individuals have a 46,XX karyotype and a normal female phenotype. MRKH syndrome may be isolated (type I MRKH syndrome) or associated with renal, cardiac, and skeletal anomalies, short stature, and auditory defects. The latter is defined as type II MRKH syndrome or the Müllerian duct aplasia/hypoplasia, renal agenesis/ectopy, and cervicothoracic somite dysplasia (MURCS) association. The majority of patients with MRKH syndrome present with primary amenorrhea. We report a case of type II MRKH syndrome who has been referred by a pediatric surgeon for detection of gonadal function. During an inguinal hernia operation, the left ovary had been observed in the hernia sac. Clinical and radiological evaluation of the patient showed an absence of the uterus and left kidney, and cervical hemi vertebra. Based on these findings, the patient was diagnosed as having type II MRKH syndrome. © 2012 by Walter de Gruyter Berlin Boston.


Ucakturk A.,Ankara Childrens Hematology and Oncology Training Hospital | Avci B.,Ondokuz Mayis University | Genc G.,Ondokuz Mayis University | Ozkaya O.,Ondokuz Mayis University | Aydin M.,Ondokuz Mayis University
Journal of Pediatric Endocrinology and Metabolism | Year: 2016

Background: We aimed at evaluating the urinary levels of kidney injury molecule-1 ( KIM-1) and neutrophil gelatinase associated lipocalin (NGAL), and the relationship between these markers and clinical and laboratory variables in normoalbuminuric children with type 1 diabetes (T1D). Methods: The study group consisted of 60 (F/M: 28/32) children with T1D with a median age of 13 (min: 7.1-max: 17.9) years and a mean HbA1c of 8.6%. The average period of treatment was 6.8±2.2 years. The control group consisted of 60 healthy children [(F/M: 32/28); median age: 13.6 (min: 6.9-max: 17.9) years]. Results: Urinary KIM-1 and NGAL levels were significantly elevated in the diabetic group (KIM-1: 0.50±0.34 ng/mg-cr; NGAL: 33±31 ng/mg-cr) compared with the nondiabetic control subjects (KIM-1: 0.26±0.25 ng/mg-cr, NGAL 13.3±14.5 ng/mg-cr) (p<0.001). No significant associations were observed between NGAL or KIM-1 and the duration of diabetes and HbA1c levels. NGAL was found to be weakly correlated with KIM-1 (p<0.005, r=0.289). Conclusions: NGAL and KIM are high in normoalbuminuric diabetic children before reduction in glomerular filtration rate. High NGAL and KIM-1 levels may indicate early diabetic kidney injury; however, we did not observe any relationship between these markers and diabetic indices. For clinical usefulness of these markers, long-term studies are required. © 2016 by De Gruyter.


Oden Akman A.,Ankara Childrens Hematology and Oncology Training Hospital | Tayfun M.,Ankara Childrens Hematology and Oncology Training Hospital | Demirel F.,Yildirim Beyazit University | Ucakturk S.A.,Ankara Childrens Hematology and Oncology Training Hospital | Gungor A.,Ankara Childrens Hematology and Oncology Training Hospital
Journal of Pediatric and Adolescent Gynecology | Year: 2015

Background: Van Wyk Grumbach syndrome (VWGS) and Kocher-Debre Semelaigne syndrome (KDSS) are rare forms of pseudo-precocious puberty and myopathy in patients with longstanding untreated hypothyroidism. We present the case of an adolescent girl who developed pseudo-precocious puberty and myopathy caused by long-term untreated hypothyroidism. Case: A 17-year-old female patient was referred to our outpatient clinic due to menstrual irregularities. She had muscle pain and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. High levels of creatinine and creatinine kinase and accompanying muscle hypertrophy were present. After the initiation of l-thyroxine therapy, the symptoms were alleviated in a short time. Conclusion: Congenital and acquired hypothyroidism should be considered in the differential diagnosis of pseudo-precocious puberty and myopathy that presents with muscle pain, muscle hypertrophy, and elevated creatinine kinase levels. © 2015 North American Society for Pediatric and Adolescent Gynecology.


PubMed | Ankara Childrens Hematology and Oncology Training Hospital
Type: Case Reports | Journal: The Turkish journal of pediatrics | Year: 2012

Prasads syndrome is characterized by geophagia, growth retardation, hypogonadism, and zinc deficiency. We report a 15-year-old boy whose medical history and clinical and laboratory findings were fully compatible with Prasads syndrome. In addition to severe growth retardation and pubertal delay, iron deficiency anemia and zinc deficiency were determined. His gliadin and endomysium antibodies were negative. The thyroid hormone levels were in normal range but basal gonadotropins and testosterone levels were low for his age. Detailed endocrinological evaluation revealed growth hormone deficiency and hypogonadotropic hypogonadism. Pituitary gland magnetic resonance imaging revealed pituitary hypoplasia. In our opinion, before the diagnosis of Prasads syndrome, endocrine evaluation should be done in these patients and hypopituitarism should be ruled out. Hypogonadotropic hypogonadism and growth hormone deficiency may be masked by Prasads syndrome.


PubMed | Ankara Childrens Hematology and Oncology Training Hospital
Type: Journal Article | Journal: Pediatrics international : official journal of the Japan Pediatric Society | Year: 2013

The aim of this study was to determine the individual and familial factors associated with metabolic control in children with type 1 diabetes (T1DM).The study was performed in 93 children with T1DM between the ages of 3 and 19 years. Children and their families completed questionnaires on sociodemographics and data associated with diabetes. Medical information from the charts was also recorded.Older age, longer diabetes duration and higher hospitalization rate for acute complications were positively associated with poor metabolic control. Good school performance, regular hospital visits, young maternal age, high paternal education level and fewer numbers of siblings were found to be negatively associated with poor metabolic control.Multiple individual and family-level factors are associated with metabolic control. These data may aid in identification of diabetic children and adolescents who have a higher risk of poor metabolic control.

Loading Ankara Childrens Hematology and Oncology Training Hospital collaborators
Loading Ankara Childrens Hematology and Oncology Training Hospital collaborators