de Vries A.,Animal Health Trust |
Taylor P.M.,Taylor Monroe
Veterinary Anaesthesia and Analgesia | Year: 2015
Objective: To compare intravenous (IV) midazolam and diazepam administered with ketamine for induction of anaesthesia in ponies, already sedated with detomidine, undergoing field castration. Study design: Prospective, randomised, 'blinded', clinical study. Animals: Twenty Welsh pony yearlings. Methods: After IV injection of detomidine (20 μg kg-1) and phenylbutazone (4.4 mg kg-1) ponies were allocated to receive either IV midazolam (group M) or diazepam (group D) (both 0.06 mg kg-1) with ketamine (2.2 mg kg-1) for induction of anaesthesia. Using simple descriptive scales, quality of sedation, induction, endotracheal intubation, surgical conditions and recovery were scored by observers blinded to treatment. Time from sedation to induction of anaesthesia, IV injection to lateral recumbency, induction to start of surgery, induction to first head lift and to standing, and total surgical time were measured. Cardiorespiratory function was assessed every 5 minutes. Time, number and total quantity of additional IV ketamine as well as any adverse effects were documented. Data were tested for normality and analysed using two-way anova with Bonferroni post hoc tests, unpaired t-tests and Mann-Whitney U tests as appropriate. Significance was set at p < 0.05. Results: There were no significant group differences in any of the measured variables except bodyweight (mean ± SD: group M 163 ± 12 kg; group D 150 ± 7 kg; p = 0.01). One pony in group M required ketamine 15 minutes after induction of anaesthesia. Surgical conditions were good in all cases; time from induction to standing was 50 ± 11 minutes in group M and 48 ± 12 minutes in group D. There were no adverse effects. Recoveries were uneventful with minimal ataxia. Conclusions and clinical relevance: Midazolam and diazepam at 0.06 mg kg-1 can be used interchangeably in combination with ketamine for IV induction of short term anaesthesia in ponies. © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.
Animal Health Trust | Date: 2013-05-24
The invention relates to the use of the TTC8 gene as a biomarker for the prognosis of a canine mammal developing progressive retinal atrophy. The invention also relates to in vitro methods of prognosing progressive retinal atrophy in a canine mammal by detecting a genetic variation within the TTC8 gene and to primers and prognostic kits for use in said method.
Animal Health Trust | Date: 2012-12-21
The invention relates to a method for detecting the presence or absence of a bacterial pathogen in a biological sample obtained from a human or animal subject, using an internal control. In particular, the invention relates to a method for detecting the presence or absence of
The Broad Institute Inc., Trustees Of Tufts College and Animal Health Trust | Date: 2014-03-13
Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line risk markers.
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.1.3-05 | Award Amount: 1.21M | Year: 2010
This European surveillance network for influenza in pigs (ESNIP) 3 will maintain and expand surveillance networks established during previous EC concerted actions (ESNIP 1, QLK2-CT-2000-01636; ESNIP 2, SSPE-022749). Three work packages (WP 2, 3, 4) aim to increase the knowledge of the epidemiology and evolution of swine influenza (SI) virus (SIV) in European pigs through organised field surveillance programmes (WP2). Virus strains detected in these programmes will be subjected to detailed characterisation both antigenically (WP3) and genetically (WP4) using standardised methodology. Specifically this will involve timely information on genomic data and generation of antigenic maps using the latest technology. These analyses will provide significant and timely added value to knowledge of SIV. A strong focus will be monitoring spread and independent evolution of pandemic H1N1 2009 virus in pigs. All these data will in turn be used to improve the diagnosis of SI by updating the reagents used in the recommended techniques (WP2). The virus bank and electronic database that were established during ESNIPs 1 and 2 will also be expanded and formally curated with relevant SIV isolates and information for global dissemination within and outwith the consortium (WP5). ESNIP 3 represents the only organised surveillance network for influenza in pigs and seeks to strengthen formal interactions with human and avian surveillance networks previously established in ESNIP 2. A timely and transparent interaction with these networks will be a key output. These approaches are entirely consistent with improved pandemic preparedness and planning for human influenza whilst providing an evidence base for decisions in relation to veterinary health. The project consortium consists of 24 participants, which contribute a blend of different specialisms and skills ensuring multi-disciplinary cutting-edge outputs. The vast majority of the partners are actively working with SIV including in a field setting. Twenty-one participants are from 11 EU member states, seven of which were actively involved in ESNIP 2. Co-operation with partners in China and North America will continue to promote a greater understanding of the epidemiology of SIVs at a global level.