Animal Genomics and Bioinformatics Division National Institute of Animal Science

Animal Genomics and Bioinformatics Division National Institute of Animal Science


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Cho E.-S.,Animal Genomics and Bioinformatics Division National Institute of Animal Science | Lee K.-T.,Animal Genomics and Bioinformatics Division National Institute of Animal Science | Kim J.-M.,Korea University | Lee S.-W.,Animal Genomics and Bioinformatics Division National Institute of Animal Science | And 4 more authors.
Animal Science Journal | Year: 2015

We identified a potential molecular marker associated with meat quality traits in the myosin heavy chain 4, MYH4 gene of Landrace pigs. Sequencing revealed a single nucleotide polymorphism (SNP; g.-1398G>T) in the 5' upstream region of MYH4. It was significantly associated with the number of type IIa muscle fibers and water-holding capacity based on filter-paper fluid uptake. The GG genotype groups had a greater number of type IIa fibers and a larger area composed of type IIa fibers than the other genotype group (P = 0.004 and P = 0.061, respectively). Expression level of MYH4 gene in the genotype TT or GT was higher than in genotype of GG (P < 0.0001). The T allele may enhance expression level of MYH4 gene and then the portion of IIb type fiber in the muscle be increased by the T allelle. Therefore, we suggest that the g.-1398G>T in the 5' upstream region of the porcine MYH4 may be used as a molecular marker for meat quality traits, although its functional effect is not defined yet. © 2015 The Authors.

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