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Anyang, South Korea

Woo G.-H.,Animal Disease Diagnostic Center | Jho Y.-S.,Snoopy Animal Hospital | Bak E.-J.,Hallym University
Journal of Veterinary Medical Science | Year: 2010

Fifteen 8-month-old fennec foxes imported from Sudan showed fever, ucopurulent ocular discharge, diarrhea, severe emaciation, seizures, and generalized ataxia, and died. Three of the 15 animals were presented for diagnostic investigation. Severe dehydration, brain congestion, and gastric ulcers were observed in all animals. In one animal, the lungs had failed to collapse and were multifocally dark red in appearance. Histopathologically, there were lymphohistiocytic meningoencephalitis with malacia, mild interstitial pneumonia, lymphoid depletion of lymphoid tissues and organs, and intestinal villous atrophy with intralesional coccidia. There were many intracytoplasmic and/or intranuclear inclusion bodies in the epithelial cells of the medullary velum, lungs, liver, kidneys, trachea, pancreas, stomach, gall bladder, urinary bladder, and ureters, and in macrophages of malacia foci and lymphocytes and macrophages of lymphoid organs. Additionally, intestinal coccidia were confirmed to be Isospora species by a fecal test. To our knowledge, this is the first report of canine distemper with intestinal coccidiosis in fennec fox.

Hong S.,Seoul National University | Lee I.,Seoul National University | Hwang H.,Seoul National University | Seo I.,Seoul National University | And 6 more authors.
Biosystems Engineering | Year: 2011

Odour from livestock production is an increasing problem in many countries. To reduce odours and establish the effects of livestock production on their surrounding communities, many studies have been carried out on odour dispersion using diffusion simulations and field experiments. Recently, computational fluid dynamics (CFD) has been effectively used to study odour dispersion. CFD can consider various atmospheric phenomena and topographical conditions to study the occurrence of odours and aerosol dispersions. The ultimate objective of this study was to develop an aerodynamic model to qualitatively and quantitatively predict odour dispersion originating from livestock facilities. This first of two papers, deals with the grid construction method, selection of fundamental design criteria and topographical modelling. A mesh model of complex topography, with a 3.6 km diameter and 2.5 km height, was developed with a fine resolution. Well known, commercially available, computational tools were used for the topographical modelling. An earlier wind tunnel experiment contributed to the selection of the grid size (to ensure grid independence), and the selection of time step and turbulence model for CFD simulation. In the second paper, methodologies for modelling of the dispersion phenomenon are presented. In the future, this model will be used to help ameliorate odour conflicts by predicting odour dispersion according to various meteorological and geographical conditions. © 2011 IAgrE.

Lee D.K.,Kyungpook National University | Park C.K.,Animal Disease Diagnostic Center | Kim S.H.,Animal Disease Diagnostic Center | Lee C.,Kyungpook National University
Virus Research | Year: 2010

Porcine epidemic diarrhea virus (PEDV) has plagued the domestic swine industry in Korea causing significant economic impacts on pig production nationwide. In the present study, we determined the complete nucleotide sequences of the spike (S) glycoprotein genes of seven Korean PEDV isolates. The entire S genes of all isolates were found to be nine nucleotides longer in length than other PEDV reference strains. This size difference was due to the combined presence of notable 15. bp insertion and 6. bp deletion within the N-terminal region of the S1 domain of the Korean isolates. In addition, the largest number of amino acid variations was accumulated in the S1 N-terminal region, leading to the presence of hypervariability in the isolates. Sequence comparisons at the peptide level of the S proteins revealed that all seven Korean isolates shared diverse similarities ranging from a 93.6% to 99.6% identity with each other but exhibited a 92.2% to 93.7% identity with other reference strains. Collectively, the sequence analysis data indicate the diversity of the PEDV isolates currently prevalent in Korea that represents a heterogeneous group. Phylogenetic analyses showed two separate clusters, in which all Korean field isolates were grouped together in the second cluster (group 2). The results indicate that prevailing isolates in Korea are phylogenetically more closely related to each other rather than other reference strains. Interestingly, the tree topology based on the nucleotide sequences representing the S1 domain or the S1 N-terminal region most nearly resembled the full S gene-based phylogenetic tree. Therefore, our data implicates a potential usefulness of the partial S protein gene including the N-terminal region in unveiling genetic relatedness of PEDV isolates. © 2010 Elsevier B.V.

Woo G.H.,Animal Disease Diagnostic Center | Kim H.Y.,Animal Disease Diagnostic Center | Bae Y.C.,Animal Disease Diagnostic Center | Jean Y.H.,Animal Disease Diagnostic Center | And 4 more authors.
Histology and Histopathology | Year: 2011

We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurological signs and watery diarrhoea. Gross petechial or ecchymotic haemorrhage affected the heart, proventriculus, liver, muscle, fat, and pancreas in chickens, and muscle in ducks. Necrotic foci were primarily present in the pancreas of both species and in the heart of domestic ducks. Histopathologically, chickens exhibited multifocal encephalomalacia, multifocal lymphohistiocytic myocarditis, multifocal necrotic pancreatitis and haemorrhage of several organs and tissues; ducks exhibited lymphohistiocytic meningoencephalitis with multifocal haemorrhages, multifocal necrotic pancreatitis, and severe necrotic myocarditis with mineralisation. The characteristic histopathologic findings of 2008 HPAI were multifocal encephalomalacia and necrotic pancreatitis accompanied by lymphohistiocytic myocarditis, and haemorrhage in various organs and tissues in chickens, whereas in ducks, they were severe necrotic myocarditis with mineralisation and necrotic pancreatitis, accompanied with lymphohistiocytic meningoencephalitis. The high mortality of domestic ducks may be intimately associated with heart failure resulting from increased H5N1 HPAI viral cardiotropism.

Woo G.-H.,Animal Disease Diagnostic Center | Kim H.-Y.,Animal Disease Diagnostic Center | Bae Y.-C.,Animal Disease Diagnostic Center | Jean Y.H.,Animal Disease Diagnostic Center | And 4 more authors.
Journal of Wildlife Diseases | Year: 2010

Over a 6-day period beginning on 15 October 2008, 93 dead or sick wild waterfowl, including Mallards, Spotbills, and teal species, were found along the shore of a branch stream of the Hangang River, which flows through Seoul, Korea, and were submitted to the National Veterinary Research and Quarantine Service (NVRQS) for diagnosis. Clinically, the affected birds showed flaccid paralysis of the legs and wings and paralysis of the neck. Grossly, no bird snowed any lesions, but all had almost empty stomachs. Histopathologic findings included mild lymphocytic hepatitis and mild lymphocytic interstitial nephritis. Clostridium botulinum type C toxin was identified in sera collected from the birds using a mouse bioassay for botulinum toxins; however, no bacteria were isolated from any of the affected birds. In addition, a low-pathogenic avian influenza virus was isolated from two Spotbills, and pesticides such as diazinon and phorate, were detected in seven Mallards. The cause of this outbreak is not clear, but an increase in organic materials from sewage due to drought, increased temperatures, and an increased number of aquatic carcasses resulting from pesticide contamination may have increased the replication of C. botulinum, contributing to the release of botulinum toxins into the waterfowl food chain. © Wildlife Disease Association 2010.

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