Anhui University of Traditional Chinese Medicine
Hefei, China

Anhui University of Chinese Medicine is a comprehensive public university based in Hefei, Anhui province, China. The university provides programmes in traditional Chinese medicine as well as in the fields of technology, engineering, management and economics. Wikipedia.

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Jiang H.,Anhui University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013

To observe the effect of shuganjianpifang on BCL-2, BAX expressions in livers of hepatic fibrosis rats and its mechanism. Sixty SD rats were randomly divided into six groups. Rat liver fibrosis was induced by CCl4 twice a week for 12 weeks. Shuganjianpifang was used daily via lavage at 7th week for 6 weeks. The contents of ALT, AST, T-BiL and Alb in serum were measured. Liver samples were taken to examine the degree of liver fibrosis by HE staining. The experessions of BCL-2 and BAX were detected by immunohisto chemistry. The expression of BCL-2, BAX mRNA was detected by RT-PCR technology. As compared with the fibrotic model group, shuganjianpifang significantly reduced histopathological change, such as steatosis, deposition, decreased the contents of ALT, AST and T-BiL, up-regulated the expression of Alb. Meanwhile shuganjianpifang could effectively inhibit the expression of BAX, significantly enhanced the expression BCL-2 in liver fibrosis rats. Shuganjianpifang can resist hepatic fibrosis possibly by up-regulating BCL-2 expression and down-regulating BAX expression.

Wu D.L.,Anhui University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2011

To investigate the chemical constituents of Carya cathayensis and their antitumor bioactivity. The compounds were isolated by Sephadex LH-20 and silica gel column chromatography. Their structures were identified by physicochemical properties and spectroscopic analysis. Then their cytotoxic activity was studied. Five compounds were elucidated as chrysophanol (1), physcion (2), beta-sitosterol (3), pinostrobin(4), 4,8-dihydroxy-1-tetralone (5). Compounds 2 and 5 are isolated from Carya cathayensis for the first time. In the MTT antitumor experiments, the compounds 1,4 and 5 have the cytotoxic activity to KB cell.

Wang G.,Anhui University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To study the chemical constituents from Kalimeris indica. Compounds were isolated and purified with silica gel and Sephadex LH-20 column chromatography, their structures were determined by using spectroscopic analysis including MS and NMR. Nine compounds were isolated and identified as tritriacontane (I), hexadecanol (II), chrysophanol (III), vanillin (IV), physcion (V), beta-sitosterol (VI), stigmasterol (VII), leinoleic acid (VII), emodin (IX). All of them, except compound IV, VI, are isolated from this genus for the first time. Compound III, IV had the protective effects with the toxicity of CCl4 on primary cultered hepatocytes.

Meng F.,Anhui University of Traditional Chinese Medicine
Menopause | Year: 2016

OBJECTIVE:: This study aims to evaluate the effectiveness and safety of Gua sha therapy on perimenopausal symptoms, quality of life, and serum female hormones in participants with perimenopausal syndrome. METHODS:: A prospective, randomized, controlled clinical trial was conducted at the First Affiliated Hospital of Nanjing University of Chinese Medicine in China. Eighty women with perimenopausal syndrome were recruited and randomized into an intervention group or a control group. Participants in the intervention group received 15-minute Gua sha treatment sessions once a week plus conventional treatment for 8 weeks, whereas participants in the control group received conventional treatment alone. The primary outcome was the change in perimenopausal symptoms and quality of life as obtained through the modified Kupperman Index (KI) and the Menopause-Specific Quality of Life. The secondary outcome was the change of serum female hormones including estrogen, follicle-stimulating hormone, and luteinizing hormone. RESULTS:: Seventy-five out of 80 participants (93.8%) completed the study—38 in the intervention group and 37 in the control group. The baseline levels of demographic and outcome measurements were comparable between the two groups. After eight sessions of intervention, the reduction in the total modified KI score was, however, 16.32?±?4.38 in the intervention group and 11.46?±?5.96 in the control group, with a difference of 4.86?±?6.15 (P?

Wu Y.,Anhui Medical University | Zhou S.,Anhui Medical University | Zhou Z.,Anhui University of Traditional Chinese Medicine | Liu B.,Anhui Medical University
Critical Care | Year: 2014

Introduction: The accurate assessment of intravascular volume status for the therapy of severe hypovolemia and shock is difficult and critical to critically ill patients. Non-invasive evaluation of fluid responsiveness by the rapid infusion of a very limited amount of volume is an important clinical goal. This study aimed to test whether echocardiographic parameters could predict fluid responsiveness in critically ill patients following a low-volume (50-ml crystalloid solution) infusion over 10 seconds.Methods: We prospectively studied 55 mechanically ventilated patients. Echocardiography was performed during a 50-ml infusion of crystalloid solution over 10 seconds and a further 450 ml over 15 minutes. Cardiac output (CO), stroke volume (SV), aortic velocity time index (VTI), and left ventricular ejection fraction (LVEF) were recorded. Patients were classified as responders (Rs) if CO increased by at least 15% following the 500-ml volume expansion or were classified as non-responders (NRs) if CO increased by less than 15%. Area under the receiver operating characteristic curves (AUC) compared CO variations after 50 ml over 10 seconds ({increment}CO50) and 500 ml over 15 minutes ({increment}CO500) and the variation of VTI after infusion of 50 ml of fluid over 10 seconds ({increment}VTI50).Results: In total, 50 patients were enrolled, and 27 (54%) of them were Rs. General characteristics, LVEF, heart rate, and central venous pressure were similar between Rs and NRs. In the Rs group, the AUC for {increment}CO50 was 0.95 ± 0.03 (P <0.01; best cutoff value, 6%; sensitivity, 93%; specificity, 91%). Moreover, {increment}CO50 and {increment}CO500 were strongly correlated (r = 0.87; P <0.01). The AUC for {increment}VTI50 was 0.91 ± 0.04 (P <0.01; best cutoff value, 9%; sensitivity, 74%; specificity, 95%). {increment}VTI50 and {increment}CO500 were positively correlated (r = 0.72; P <0.01).Conclusion: In critically ill patients, the variation of CO and VTI after the administration of 50-ml crystalloid solution over 10 seconds ({increment}CO50 and {increment}VTI50) can accurately predict fluid responsiveness.Trial registration: Current Controlled Trials ISRCTN10524328. Registered 12 December 2013. © 2014 Wu et al.; licensee BioMed Central Ltd.

Yang J.,Anhui University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2012

To study the structural characteristics of medicinal parts at different developmental stages of Semiaquilegia adoxoides. Observed on sections of medicinal parts of Semiaquilegia adoxoides at various developmental stages during growth periods. There was a great difference between the upper and bottom of the medicinal parts of Semiaquilegia adoxoides: rhizome at the top of root had the structure of rhizome with pith; The upper one third of enlarged root was root-stem transition zone, also with pith; And the other two thirds of enlarged root had the structure of root without pith. The microscopic structures of the medicinal parts of Semiaquilegia adoxoides at various developmental stages presented great disparities, the structures regularly increased as the size of plant increased. It was the first time to find that there were structure of growth rings in xylem of the root and rhizome of Semiaquilegia adoxoides. The method of identification of characteristics and histology of medicinal parts of Semiaquilegia adoxoides at different developmental stages is established, and the results provide a basis for identification of Semiaquilegia adoxoides medicinal materials.

Yang J.,Anhui University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2011

To study the status and regular pattern in growing development of wild Pseudostellaria heterophylla. Observed and studied on wild Pseudostellaria heterophylla during growth periods continuously. The growing development of Pseudostellaria heterophylla could be divided into three stages: asexual reproduction stage, coexistence of asexual and sexual reproduction stage. In the first two years of seed germination, there was only asexual reproduction, from which substitute tuberous root and cauline tuberous root were formed; Afterward flowering and fructifying sexual reproduction occurred to the plant that had developed from tuberous root while it continued with asexual reproduction; Only sexual reproduction existed during the last year of the Pseudostellaria heterophylla plant before its death. The Pseudostellaria heterophylla plant above ground grew from early spring to late autumn and over-wintered with tuberous root. There were two patterns of asexual reproduction: substitution with tuberous root in spring and expanding of adventitious root on stolon into cauline tuberous root in autumn. All tuberous roots of Pseudostellaria heterophylla were originated from adventitious root; The existence of tuberous root was one year at most; The rapidly expanding period of tuberous root was during February and March. The results provide a reference for reformative cultivation of Pseudostellaria heterophylla.

Zhu G.,Anhui University of Traditional Chinese Medicine | Wang X.,Anhui University of Traditional Chinese Medicine | Wu S.,Anhui University of Traditional Chinese Medicine | Li Q.,Anhui University of Traditional Chinese Medicine
Neurochemistry International | Year: 2012

In an attempt to clarify the protective effect of puerarin on toxin-insulted dopaminergic neuronal death, this present study was carried out by using a typical Parkinson's disease (PD) model - 1-methyl-4-phenylpyridinium iodide (MPP +)-induced dopaminergic SH-SY5Y cellular model. Data are presented, which showed that puerarin up-regulated Akt phosphorylation in both of MPP +-treated and non-MPP +-treated cells. The presence of PI3K inhibitor LY294002 completely blocked puerarin-induced activation of Akt phosphorylation. Moreover, puerarin decreased MPP +-induced cell death, which was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002. We further demonstrated that puerarin protected against MPP +-induced p53 nuclear accumulation, Puma (p53-upregulated mediator of apoptosis) and Bax expression and caspase-3-dependent programmed cell death (PCD). This protection was blocked by applying a PI3K/Akt inhibitor. Additionally, it was Pifithrin-α, but not Pifithrin-μ, which blocked MPP +-induced Puma and Bax expression, caspase-3 activation and cell death. Collectively, these data suggest that the activation of PI3K/Akt pathway is involved in the protective effect of puerarin against MPP +-induced neuroblastoma SH-SY5Y cell death through inhibiting nuclear p53 accumulation and subsequently caspase-3-dependent PCD. Puerarin might be a potential therapeutic agent for PD. © 2012 Elsevier Ltd. All rights reserved.

Liang H.-W.,Anhui University of Science and Technology | Zhang W.-J.,Anhui University of Science and Technology | Ma Y.-N.,Anhui University of Traditional Chinese Medicine | Cao X.,Anhui University of Science and Technology | And 3 more authors.
ACS Nano | Year: 2011

Translating the unique characteristics of individual nanoscale components into macroscopic materials such as membranes or sheets still remains a challenge, as the engineering of these structures often compromises their intrinsic properties. Here, we demonstrate that the highly active carbonaceous nanofibers (CNFs), which are prepared through a template-directed hydrothermal carbonization process, can be used as a versatile nanoscale scaffold for constructing macroscopic multifunctional membranes. In order to demonstrate the broad applicability of the CNF scaffold, we fabricate a variety of CNF-based composite nanofibers, including CNFs-Fe3O4, CNFs-TiO 2, CNFs-Ag, and CNFs-Au through various chemical routes. Importantly, all of them inherit unique dimensionality (high aspect ratio) and mechanical properties (flexibility) of the original CNF scaffolds and thus can be assembled into macroscopic free-standing membranes through a simple casting process. We also demonstrate the wide application potentials of these multifunctional composite membranes in magnetic actuation, antibiofouling filtration, and continuous-flow catalysis. © 2011 American Chemical Society.

Li Y.,Anhui University of Traditional Chinese Medicine
Omics : a journal of integrative biology | Year: 2013

Sepsis is a leading cause of morbidity and mortality in critically ill patients. OMICS and systems pharmacology approaches offer the promise of new therapeutic candidates for the treatment of patients with sepsis. Qin-Re-Jie-Du (QRJD) and Liang-Xue-Huo-Xue (LXHX) are two traditional Chinese herbal medicine (CHM) formulas with putative effects in sepsis treatment. The present study aimed to assess their efficacy in an experimental model of sepsis in rats (cecal ligation and punctures) and investigate their mechanism of action using a 1H-NMR metabolomics approach. Rats were randomly divided into four groups (i.e., model group, sham control group, and two CHM treatment groups). Water extracts of QRJD and LXHX were orally administered to the two CHM treatment groups at a dose of 24 g/kg of body weight, once daily for 3 consecutive days. The same volume of 0.9% saline solution was orally administered to the model and sham surgery groups. Plasma samples were collected and measured using 600 MHz 1H-NMR spectroscopy. As a result, 18 potential metabolite biomarkers involved in multiple metabolic pathways, including increased energy metabolism, fat mobilization, and disrupted amino acid metabolism, were identified in septic rats. The principal component analysis (PCA) and partial least squares discriminant (PLS-DA) plots of the metabolic state correlated well with the mortality and clinical biochemistry results. An analysis of potential biomarkers verified the holistic effects of the two CHM formulas. The Cori cycle was positively regulated in the QRJD-treated formulas treatment group but also inhibited in the LXHX-treated group, which demonstrates the different efficacies of these solutions in septic rats.

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