Anhui University of Science and Technology one of the five key universities in Anhui Province, China. It is situated in Huainan City, Anhui Province, which is also known as a green city and as a base of science and education in China. Covering a land area of 1,300 mu, the university is divided into three branches. Wikipedia.
Feng C.,Nanyang Technological University |
Loh T.-P.,Anhui University of Science and Technology
Angewandte Chemie - International Edition | Year: 2014
The rhodium(III)-catalyzed ortho C-H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. Hot rhod: A rhodium-catalyzed, electronically reversed Sonogashira reaction between unbiased arenes and the hypervalent iodine reagent 1 proceeds through C-H activation. This reaction displays excellent functional-group tolerance and high efficiency, and thus opens a new synthetic pathway to access functionalized alkynes. Cp*=C5Me5, DCE=1,2-dichloroethane, Piv=pivaloyl, TIPS=triisopropylsilyl. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Hu J.,Anhui University of Science and Technology |
Liu S.,Anhui University of Science and Technology
Accounts of Chemical Research | Year: 2014
ConspectusAll living organisms and soft matter are intrinsically responsive and adaptive to external stimuli. Inspired by this fact, tremendous effort aiming to emulate subtle responsive features exhibited by nature has spurred the invention of a diverse range of responsive polymeric materials. Conventional stimuli-responsive polymers are constructed via covalent bonds and can undergo reversible or irreversible changes in chemical structures, physicochemical properties, or both in response to a variety of external stimuli. They have been imparted with a variety of emerging applications including drug and gene delivery, optical sensing and imaging, diagnostics and therapies, smart coatings and textiles, and tissue engineering.On the other hand, in comparison with molecular chemistry held by covalent bonds, supramolecular chemistry built on weak and reversible noncovalent interactions has emerged as a powerful and versatile strategy for materials fabrication due to its facile accessibility, extraordinary reversibility and adaptivity, and potent applications in diverse fields. Typically involving more than one type of noncovalent interactions (e.g., hydrogen bonding, metal coordination, hydrophobic association, electrostatic interactions, van der Waals forces, and π-π stacking), host-guest recognition refers to the formation of supramolecular inclusion complexes between two or more entities connected together in a highly controlled and cooperative manner. The inherently reversible and adaptive nature of host-guest molecular recognition chemistry, stemming from multiple noncovalent interactions, has opened up a new platform to construct novel types of stimuli-responsive materials. The introduction of host-guest chemistry not only enriches the realm of responsive materials but also confers them with promising new applications. Most intriguingly, the integration of responsive polymer building blocks with host-guest recognition motifs will endow the former with further broadened responsiveness to external stimuli and accordingly more sophisticated functions.In this Account, we summarize recent progress in the field of responsive polymeric materials containing host-guest recognition motifs with selected examples and highlight their versatile functional applications, whereas small molecule-oriented host-guest supramolecular systems are excluded. We demonstrate how the introduction of host-guest chemistry into conventional polymer systems can modulate their responsive modes to external stimuli. Moreover, the responsive specificity and selectivity of polymeric systems can also be inherited from the host-guest recognition motifs, and these features provide extra advantages in terms of function integration. The following discussions are categorized in terms of design and functions, namely, host-guest chemistry toward the fabrication of responsive polymers and assemblies, optical sensing and imaging, drug and gene delivery, and self-healing materials. A concluding remark on future developments is also presented. We wish this prosperous field would incur more original and evolutionary ideas and benefit fundamental research and our daily life in a more convenient way. © 2014 American Chemical Society.
Zhan J.,Anhui University of Science and Technology
Molecular systems biology | Year: 2010
One limit on developing complex synthetic gene circuits is the lack of basic components such as transcriptional logic gates that can process combinatorial inputs. Here, we propose a strategy to construct such components based on reusable designs and convergent reengineering of well-studied natural systems. We demonstrated the strategy using variants of the transcription factor (TF) LacI and operator Olac that form specifically interacting pairs. Guided by a mathematical model derived from existing quantitative knowledge, rational designs of transcriptional NAND, NOR and NOT gates have been realized. The NAND gates have been designed based on direct protein-protein interactions in coupling with DNA looping. We demonstrated that the designs are reusable: a multiplex of logic devices can be readily created using the same designs but different combinations of sequence variants. The designed logic gates are combinable to form compound circuits: a demonstration logic circuit containing all three types of designed logic gates has been synthesized, and the circuit truthfully reproduces the pre-designed input-output logic relations.
Liu W.,Anhui University of Science and Technology
Optics Letters | Year: 2015
A new radiation scheme, which adopts the high-order harmonics of a train of electron bunches to excite the highorder guided mode, is proposed and investigated by numerical simulations. By applying this scheme, the radiation with frequency close to 1 THz is generated from a waveguide with relatively big-size structure, and the bunching frequency is much lower than the radiation frequency.This scheme may offer a promising candidate for practical terahertz source since it breaks the two main bottlenecks of the vacuum electronic devices in the terahertz region: very tiny-size structure and unapproachable electron beam. © 2015 Optical Society of America.
Qi F.,Anhui University of Science and Technology
Proceedings of the Combustion Institute | Year: 2013
Combustion is directly related to energy conversion and the environment. Gas-phase chemical reactions such as thermal decomposition, oxidation and recombination play a critical role in combustion processes. Here we review six applications of synchrotron vacuum-ultraviolet (VUV) photoionization mass spectrometry (PIMS) in fundamental studies of combustion chemistry. These applications range from the use of flow reactors to probe elementary reaction kinetics, studies of pyrolysis in plug-flow reactors and oxidation in jet-stirred reactors, studies of spatial evolution of species concentrations in premixed and non-premixed flames, product distributions in pyrolysis of biomass, and analysis of polycyclic aromatic hydrocarbon (PAH) formation. These experiments provide valuable data for the development and validation of detailed chemical kinetic models. Furthermore, some additional potential applications are proposed. © 2012 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
Wang G.-W.,Anhui University of Science and Technology
Chemical Society Reviews | Year: 2013
Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions. This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels-Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc. The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compounds. © 2013 The Royal Society of Chemistry.
Ge Z.,Anhui University of Science and Technology |
Liu S.,Anhui University of Science and Technology
Chemical Society Reviews | Year: 2013
Self-assembled nanostructures of amphiphilic and double hydrophilic block copolymers have been increasingly utilized as potent polymeric nanocarriers of therapeutic drugs, genes, bioactive molecules, and imaging/contrast agents due to improved water solubility, bioavailability, and extended blood circulation duration. Though passive and active targeted drug delivery strategies have long been proposed to promote desirable drug accumulation specifically at the disease sites, the introduction of stimuli-responsiveness into self-assembled block copolymer nanocarriers can additionally lead to controlled/triggered release of therapeutic/imaging agents into target pathological tissues and cells, with concomitant advantages of enhanced delivery efficiency and therapeutic efficacy. Appropriately designed stimuli-responsive block copolymer assemblies can exhibit chemical structure transformation, microstructural rearrangement and inversion, or even disassembly into unimers or smaller ones under external stimuli such as pH, temperature, ion strength, redox potential, light, electric, and magnetic fields, and specific bioactive molecules and metabolites. Compared to normal tissues, pathological sites such as tumor tissues typically exhibit vascular abnormalities, weak acidity (∼pH 6.8), abnormal temperatures, over-expressed proteins and enzymes, hypoxia, high levels of metabolites and reactive small molecule species, etc. Moreover, upon cellular uptake, drug-loaded polymeric nanocarriers will be subjected to intracellular pH gradients (pH 5.9-6.2 in early endosomes and pH 5.0-5.5 in late endosomes and lysosomes) and redox and H2O2 gradients within different cell organelles and the cytosol. Thus, block copolymer nanocarriers responsive to the above described bio-relevant stimuli or biochemical signals characteristic of pathologic tissues and cells will provide an alternative type of "active targeting" strategy, which can be utilized to further boost therapeutic efficacy and imaging sensitivity via disease site-specific delivery and controlled release. A variety of extracellular or intracellular stimuli innate to disease sites, such as mildly acidic pH, temperature, enzymes (matrix metalloproteinase, β-glucuronidase, and phosphatase), oxidative/reductive microenvironments, and abnormal levels of bioactive molecules or metabolites, have been utilized for this purpose. In this review, we summarize recent advances in stimuli-responsive block copolymer assemblies which are responsive to tumor and intracellular microenvironments and their applications in anticancer drug delivery and enhanced imaging sensitivity. © 2013 The Royal Society of Chemistry.
Zhang X.,Anhui University of Science and Technology |
Xie Y.,Anhui University of Science and Technology
Chemical Society Reviews | Year: 2013
Free-standing two-dimensional (2D) crystals with atomic thickness have attracted extensive attention because of their novel electronic, optical, mechanical and biocompatible properties, and so on. In recent years, the study of atomically thick 2D crystals has mainly focused on the layered materials with weak van der Waals forces between the layers. For the lack of executable synthetic strategies, preparation of atomically thick 2D crystals with a nonlayered structure or quasi-layered structure with relatively strong bonds between the layers is still a great challenge. This review mainly focuses on recent advances in synthetic strategies for atomically thick 2D crystals with a nonlayered structure as well as the quasi-layered structure with relatively strong bonds between the layers. Furthermore, methods for the modulation of the electronic structures of 2D crystals along with assembly and transfer techniques of the 2D crystals are discussed. The key points of each strategy in preparation, electronic structure modulation, assembly and transfer processes are also presented. This journal is © The Royal Society of Chemistry 2013.
Feng C.,Anhui University of Science and Technology
Angewandte Chemie (International ed. in English) | Year: 2013
Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3 -functionalized acrylamide derivatives. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Ding G.-J.,Anhui University of Science and Technology
Nuclear Physics B | Year: 2010
We present a supersymmetric model of quark and lepton based on S 4×Z 3×Z 4 flavor symmetry. The S 4 symmetry is broken down to Klein four and Z 3 subgroups in the neutrino and the charged lepton sectors, respectively. Tri-Bimaximal mixing and the charged lepton mass hierarchies are reproduced simultaneously at leading order. Moreover, a realistic pattern of quark masses and mixing angles is generated with the exception of the mixing angle between the first two generations, which requires a small accidental enhancement. It is remarkable that the mass hierarchies are controlled by the spontaneous breaking of flavor symmetry in our model. The next to leading order contributions are studied, all the fermion masses and mixing angles receive corrections of relative order λc2 with respect to the leading order results. The phenomenological consequences of the model are analyzed, the neutrino mass spectrum can be normal hierarchy or inverted hierarchy, and the combined measurement of the 0ν2β decay effective mass m ββ and the lightest neutrino mass can distinguish the normal hierarchy from the inverted hierarchy. © 2009 Elsevier B.V.