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Yin D.,Anhui University of Traditional Chinese Medicine | Yin D.,China Pharmaceutical University | Liu Z.,Anhui University of Traditional Chinese Medicine | Peng D.,Anhui University of Traditional Chinese Medicine | And 4 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2013

Tao-Hong-Si-Wu decoction (TSD) is a famous traditional Chinese medicine (TCM) and widely used for ischemic disease in China. TSD medicated serum was prepared after oral administration of TSD (1.6 g/kg) twice a day for 3 days in rats. TSD medicated serum induced human umbilical vein endothelial cells (HUVECs) proliferation, VEGF secretion, and nitric oxide (NO) production. These promoted effects of TSD were partly inhibited by treatment with PI3K inhibitor (LY294002) or eNOS inhibitor (L-NAME), respectively, and completely inhibited by treatment with LY294002 and L-NAME simultaneously. Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling. TSD medicated serum contains hydroxysafflor yellow A, ferulic acid, and ligustilide detected by UPLC with standards, so these effect of TSD medicated serum may be associated with these three active compounds absorbed in serum. © 2013 DengKe Yin et al.


Xu F.,China Pharmaceutical University | Xu F.,Anhui University of Traditional Chinese Medicine | Peng D.,Anhui Provincial Key Laboratory for Chinese Medicine Research and Development | Peng D.,Anhui University of Traditional Chinese Medicine | And 7 more authors.
Phytomedicine | Year: 2011

Anti-depression effects of Danggui-Shaoyao-San (DSS, 1.8-7.2 g/kg, orally), a famous Chinese compound prescription with a fixed combination, on forced swimming test (FST) and chronic unpredictable mild stress (CUMS) model were investigated. DSS (7.2 g/kg, orally, 7 days) shortened immobility time in FST model and DSS (3.6 or 7.2 g/kg, orally, 21 days) increased the open-field activities and the percentage of sugar preference in CUMS model. DSS (7.2 g/kg, orally, 21 days) also decreased the content of arginine vasopressin (AVP) in the pituitary and the expression of AVP mRNA in hypothalamus compared with the stress control group. These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system. © 2011 Elsevier GmbH.

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